JP5161472B2 - 鎮痛用組成物 - Google Patents
鎮痛用組成物 Download PDFInfo
- Publication number
- JP5161472B2 JP5161472B2 JP2007091793A JP2007091793A JP5161472B2 JP 5161472 B2 JP5161472 B2 JP 5161472B2 JP 2007091793 A JP2007091793 A JP 2007091793A JP 2007091793 A JP2007091793 A JP 2007091793A JP 5161472 B2 JP5161472 B2 JP 5161472B2
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- JP
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- Prior art keywords
- vitamin
- analgesic
- pain
- weight
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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Description
実施例1〜12及び比較例1〜4
以下のとおり酢酸ライジング法による鎮痛試験を行った。
鎮痛効果(%)=(1−被験群の総ライジング数/コントロール群の総ライジング数)×100
表2〜4に記載の処方に従ってフィルムコーティング剤を製剤した。具体的には、ヒドロキシプロピルメチルセルロース、酸化チタン、カルナウバロウおよびマクロゴール以外を処方に従って量りとり、水を加えて混練、造粒、乾燥、打錠することによって素錠を製した。さらにヒドロキシプロピルメチルセルロース、酸化チタンおよびマクロゴールを溶媒に混和したものを、噴霧コーティングにより前記素錠にコーティングし、カルナウバロウで表面を処理しフィルムコーティング剤を製した。ヒドロキシプロピルメチルセルロース、酸化チタンおよびマクロゴールの溶媒としては、水/エタノール混液を使用し、水とエタノールの配合比率(重量比)が、水:エタノール=60:40、50:50、25:75および5:95の4種を用いた。
Claims (3)
- イブプロフェンとビタミンB 12 及び葉酸を含有することを特徴とする鎮痛用組成物。
- 前記ビタミンB 12 及び葉酸の配合量は、前記イブプロフェン1重量部に対して、総量で0.001〜100重量部である、請求項1記載の鎮痛用組成物。
- 前記ビタミンB 12 の配合量は、葉酸1重量部に対して、0.5〜10重量部である、請求項1又は2に記載の鎮痛用組成物。
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JP2011168580A (ja) * | 2010-01-19 | 2011-09-01 | Daiichi Sankyo Healthcare Co Ltd | 医薬組成物 |
JP6106359B2 (ja) * | 2010-12-13 | 2017-03-29 | 第一三共ヘルスケア株式会社 | ロキソプロフェンナトリウムとビタミンb1を含有する固形製剤 |
JP7026457B2 (ja) * | 2016-07-07 | 2022-02-28 | 第一三共ヘルスケア株式会社 | ロキソプロフェン又はその塩及びビタミンb12類を含有する経口用医薬組成物 |
JP7523879B2 (ja) * | 2016-10-31 | 2024-07-29 | エスエス製薬株式会社 | 医薬組成物 |
ES2977276T3 (es) * | 2019-08-26 | 2024-08-21 | Dsm Ip Assets Bv | Forma de dosificación oral sólida que comprende naproxeno y vitamina B12 |
MX2022002442A (es) * | 2019-08-26 | 2022-03-22 | Dsm Ip Assets Bv | Forma de dosificacion oral solida que comprende naproxeno y vitamina b6. |
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