JP5154954B2 - 選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用 - Google Patents
選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用 Download PDFInfo
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- JP5154954B2 JP5154954B2 JP2007557300A JP2007557300A JP5154954B2 JP 5154954 B2 JP5154954 B2 JP 5154954B2 JP 2007557300 A JP2007557300 A JP 2007557300A JP 2007557300 A JP2007557300 A JP 2007557300A JP 5154954 B2 JP5154954 B2 JP 5154954B2
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- tetrahydro
- thiazoline
- dideoxy
- glucopyranoso
- pyrano
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| WO2014171206A1 (ja) * | 2013-04-17 | 2014-10-23 | Yuasa Tomoyuki | 糖尿病治療薬の新規なスクリーニング方法 |
| JP6563017B2 (ja) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
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| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| KR102839500B1 (ko) | 2018-08-22 | 2025-07-28 | 아셰뉴론 에스아 | 글리코시다제 억제제로서 유용한 피페라진 유도체의 숙시네이트 및 푸마레이트 산 부가염 |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| CN114524854B (zh) * | 2022-02-25 | 2023-05-26 | 中国农业大学 | 一种糖基芳香环碳苷衍生物及其制备方法与应用 |
| WO2024083820A1 (en) | 2022-10-18 | 2024-04-25 | Institut National de la Santé et de la Recherche Médicale | Method and composition for determining the level of o-glcnacylation in horses |
| CN116376875B (zh) * | 2023-03-03 | 2024-02-23 | 云南师范大学 | 耐热性提高的n-乙酰氨基葡萄糖苷酶突变体及其应用 |
| CN116555229B (zh) * | 2023-05-25 | 2024-09-20 | 云南师范大学 | N-乙酰氨基葡萄糖苷酶突变体、重组表达载体及菌和应用 |
| CN118086249B (zh) * | 2024-01-24 | 2024-12-06 | 云南师范大学 | 一种协同提高酶活和热稳定性的n-乙酰氨基葡萄糖苷酶突变体及其制备与应用 |
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| GB9818732D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| US6774140B1 (en) * | 1999-05-11 | 2004-08-10 | The Scripps Research Institute | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
| WO2002072860A1 (en) * | 2001-03-14 | 2002-09-19 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for producing hyaluronic acid or its derivative |
| US20070066543A1 (en) * | 2003-05-22 | 2007-03-22 | The Hospital For Sick Children | Treatment of tay sachs or sandhoff diseases by enhancing hexosaminidase activity |
| EP2057171A4 (en) * | 2006-08-31 | 2010-04-21 | Univ Fraser Simon | SELECTIVE GLYCOSIDASE INHIBITORS AND APPLICATIONS THEREOF |
| US9079868B2 (en) * | 2008-08-01 | 2015-07-14 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2010012106A1 (en) * | 2008-08-01 | 2010-02-04 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US20110301217A1 (en) * | 2008-09-16 | 2011-12-08 | David Jaro Vocadlo | Selective Glycosidase Inhibitors and Uses Thereof |
| US9120781B2 (en) * | 2010-05-11 | 2015-09-01 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| EP2638052B1 (en) * | 2010-11-08 | 2017-03-22 | Alectos Therapeutics, Inc. | Selective glycosidase inhibitors and uses thereof |
| PL2655388T3 (pl) * | 2010-12-23 | 2016-12-30 | Selektywne inhibitory glikozydazy i ich zastosowania | |
| WO2012126091A1 (en) * | 2011-03-24 | 2012-09-27 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9718854B2 (en) * | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
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2006
- 2006-03-01 AU AU2006220187A patent/AU2006220187B2/en not_active Ceased
- 2006-03-01 CA CA2599843A patent/CA2599843C/en not_active Expired - Fee Related
- 2006-03-01 CA CA2819464A patent/CA2819464A1/en not_active Abandoned
- 2006-03-01 EP EP11184538A patent/EP2436687A1/en not_active Withdrawn
- 2006-03-01 CN CN2006800149950A patent/CN101208352B/zh not_active Expired - Fee Related
- 2006-03-01 JP JP2007557300A patent/JP5154954B2/ja not_active Expired - Fee Related
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- 2006-03-01 US US11/817,465 patent/US20080287375A1/en not_active Abandoned
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| CA2819464A1 (en) | 2006-09-08 |
| JP2008531604A (ja) | 2008-08-14 |
| CA2599843C (en) | 2013-08-27 |
| AU2006220187B2 (en) | 2012-11-08 |
| EP1869060A4 (en) | 2009-08-12 |
| WO2006092049A1 (en) | 2006-09-08 |
| EP2436687A1 (en) | 2012-04-04 |
| US20080287375A1 (en) | 2008-11-20 |
| CN101208352A (zh) | 2008-06-25 |
| EP1869060A1 (en) | 2007-12-26 |
| EP1869060B1 (en) | 2012-08-15 |
| CA2599843A1 (en) | 2006-09-08 |
| AU2006220187A1 (en) | 2006-09-08 |
| CN101208352B (zh) | 2013-08-07 |
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