JP5154954B2 - 選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用 - Google Patents
選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用 Download PDFInfo
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- JP5154954B2 JP5154954B2 JP2007557300A JP2007557300A JP5154954B2 JP 5154954 B2 JP5154954 B2 JP 5154954B2 JP 2007557300 A JP2007557300 A JP 2007557300A JP 2007557300 A JP2007557300 A JP 2007557300A JP 5154954 B2 JP5154954 B2 JP 5154954B2
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- tetrahydro
- thiazoline
- dideoxy
- glucopyranoso
- pyrano
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| US9079868B2 (en) * | 2008-08-01 | 2015-07-14 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| JP2012502884A (ja) * | 2008-09-16 | 2012-02-02 | サイモン フレイザー ユニバーシティ | 選択的グリコシダーゼ阻害剤およびその使用 |
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| US10668092B2 (en) | 2010-09-24 | 2020-06-02 | The John Hopkins University | Compositions and methods for treatment of inflammatory disorders |
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| CA2822493C (en) | 2010-12-23 | 2018-11-20 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
| US8927507B2 (en) | 2011-03-24 | 2015-01-06 | Ernest J. McEachern | Selective glycosidase inhibitors and uses thereof |
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| CN103889996B (zh) * | 2011-06-27 | 2016-02-03 | 阿列科托斯治疗有限公司 | 选择性糖苷酶抑制剂及其用途 |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
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| SG2014009617A (en) * | 2011-08-25 | 2014-05-29 | Merck Patent Gmbh | Pyrano [3, 2 - d] [1, 3] thiazole as glycosidase inhibitors |
| RU2707292C2 (ru) * | 2012-05-08 | 2019-11-26 | Мерк Шарп И Доум Корп. | Проницаемые ингибиторы гликозидазы и их применения |
| US9670195B2 (en) | 2012-08-31 | 2017-06-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| WO2014032188A1 (en) | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| WO2014052453A1 (en) | 2012-09-25 | 2014-04-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Oral therapy of necrotizing enterocolitis |
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| WO2014100934A1 (en) | 2012-12-24 | 2014-07-03 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| WO2014171206A1 (ja) * | 2013-04-17 | 2014-10-23 | Yuasa Tomoyuki | 糖尿病治療薬の新規なスクリーニング方法 |
| MA53944A (fr) | 2014-08-28 | 2021-08-25 | Asceneuron Sa | Inhibiteurs de la glycosidase |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| MA43677A (fr) | 2016-02-25 | 2018-11-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
| WO2017144637A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Acid addition salts of piperazine derivatives |
| CN108884078A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
| US12195455B2 (en) | 2018-08-22 | 2025-01-14 | Asceneuron Sa | Succinate and fumarate acid addition salts of piperazine derivatives |
| WO2020039027A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Pyrrolidine glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| CN114524854B (zh) * | 2022-02-25 | 2023-05-26 | 中国农业大学 | 一种糖基芳香环碳苷衍生物及其制备方法与应用 |
| WO2024083820A1 (en) | 2022-10-18 | 2024-04-25 | Institut National de la Santé et de la Recherche Médicale | Method and composition for determining the level of o-glcnacylation in horses |
| CN116376875B (zh) * | 2023-03-03 | 2024-02-23 | 云南师范大学 | 耐热性提高的n-乙酰氨基葡萄糖苷酶突变体及其应用 |
| CN116555229B (zh) * | 2023-05-25 | 2024-09-20 | 云南师范大学 | N-乙酰氨基葡萄糖苷酶突变体、重组表达载体及菌和应用 |
| CN118086249B (zh) * | 2024-01-24 | 2024-12-06 | 云南师范大学 | 一种协同提高酶活和热稳定性的n-乙酰氨基葡萄糖苷酶突变体及其制备与应用 |
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| GB9818732D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| US6774140B1 (en) * | 1999-05-11 | 2004-08-10 | The Scripps Research Institute | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
| WO2002072860A1 (en) * | 2001-03-14 | 2002-09-19 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for producing hyaluronic acid or its derivative |
| US20070066543A1 (en) * | 2003-05-22 | 2007-03-22 | The Hospital For Sick Children | Treatment of tay sachs or sandhoff diseases by enhancing hexosaminidase activity |
| US8334310B2 (en) * | 2006-08-31 | 2012-12-18 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US9079868B2 (en) * | 2008-08-01 | 2015-07-14 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| AU2009276222B2 (en) * | 2008-08-01 | 2015-03-05 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| JP2012502884A (ja) * | 2008-09-16 | 2012-02-02 | サイモン フレイザー ユニバーシティ | 選択的グリコシダーゼ阻害剤およびその使用 |
| EP2569291B1 (en) * | 2010-05-11 | 2016-04-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2012061927A1 (en) * | 2010-11-08 | 2012-05-18 | Alectos Therapeutics, Inc. | Selective glycosidase inhibitors and uses thereof |
| CA2822493C (en) * | 2010-12-23 | 2018-11-20 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
| US8927507B2 (en) * | 2011-03-24 | 2015-01-06 | Ernest J. McEachern | Selective glycosidase inhibitors and uses thereof |
| WO2012129651A1 (en) * | 2011-03-31 | 2012-10-04 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
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2006
- 2006-03-01 WO PCT/CA2006/000300 patent/WO2006092049A1/en not_active Ceased
- 2006-03-01 EP EP06705254A patent/EP1869060B1/en not_active Not-in-force
- 2006-03-01 US US11/817,465 patent/US20080287375A1/en not_active Abandoned
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- 2006-03-01 CA CA2819464A patent/CA2819464A1/en not_active Abandoned
- 2006-03-01 CN CN2006800149950A patent/CN101208352B/zh not_active Expired - Fee Related
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| AU2006220187B2 (en) | 2012-11-08 |
| CA2599843A1 (en) | 2006-09-08 |
| CA2599843C (en) | 2013-08-27 |
| CA2819464A1 (en) | 2006-09-08 |
| US20080287375A1 (en) | 2008-11-20 |
| CN101208352B (zh) | 2013-08-07 |
| JP2008531604A (ja) | 2008-08-14 |
| EP1869060A1 (en) | 2007-12-26 |
| EP1869060A4 (en) | 2009-08-12 |
| WO2006092049A1 (en) | 2006-09-08 |
| CN101208352A (zh) | 2008-06-25 |
| AU2006220187A1 (en) | 2006-09-08 |
| EP2436687A1 (en) | 2012-04-04 |
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