JP5053503B2 - 過増殖状態を処置するための方法および組成物 - Google Patents

過増殖状態を処置するための方法および組成物 Download PDF

Info

Publication number
JP5053503B2
JP5053503B2 JP2003567445A JP2003567445A JP5053503B2 JP 5053503 B2 JP5053503 B2 JP 5053503B2 JP 2003567445 A JP2003567445 A JP 2003567445A JP 2003567445 A JP2003567445 A JP 2003567445A JP 5053503 B2 JP5053503 B2 JP 5053503B2
Authority
JP
Japan
Prior art keywords
phenyl
pyrrolo
benzyloxy
pyrimidin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003567445A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005517040A (ja
JP2005517040A5 (enExample
Inventor
チャールズ・ディーン・スタイルズ
カルロス・ガルシア−エチェベリア
Original Assignee
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド filed Critical デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
Publication of JP2005517040A publication Critical patent/JP2005517040A/ja
Publication of JP2005517040A5 publication Critical patent/JP2005517040A5/ja
Application granted granted Critical
Publication of JP5053503B2 publication Critical patent/JP5053503B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2003567445A 2002-02-14 2003-02-14 過増殖状態を処置するための方法および組成物 Expired - Fee Related JP5053503B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35691202P 2002-02-14 2002-02-14
US60/356,912 2002-02-14
PCT/EP2003/001507 WO2003068265A1 (en) 2002-02-14 2003-02-14 Methods and compositions for treating hyperproliferative conditions

Publications (3)

Publication Number Publication Date
JP2005517040A JP2005517040A (ja) 2005-06-09
JP2005517040A5 JP2005517040A5 (enExample) 2006-03-30
JP5053503B2 true JP5053503B2 (ja) 2012-10-17

Family

ID=27734705

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003567445A Expired - Fee Related JP5053503B2 (ja) 2002-02-14 2003-02-14 過増殖状態を処置するための方法および組成物

Country Status (11)

Country Link
EP (1) EP1476192B1 (enExample)
JP (1) JP5053503B2 (enExample)
CN (1) CN100591355C (enExample)
AT (1) ATE360442T1 (enExample)
AU (1) AU2003205768A1 (enExample)
BR (1) BR0307629A (enExample)
CA (1) CA2476000A1 (enExample)
DE (1) DE60313434T2 (enExample)
ES (1) ES2283744T3 (enExample)
PT (1) PT1476192E (enExample)
WO (1) WO2003068265A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
JP2007523956A (ja) * 2004-02-25 2007-08-23 ダナ−ファーバー キャンサー インスティテュート インク. 腫瘍細胞増殖を阻害するための方法
CN1960993A (zh) 2004-04-02 2007-05-09 Osi制药公司 6,6-双环取代的杂双环蛋白激酶抑制剂
US7329495B2 (en) 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
MY139689A (en) 2004-07-20 2009-10-30 Osi Pharm Inc Imidazotriazines as protein kinase inhibitors
US8062838B2 (en) 2005-09-20 2011-11-22 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
EP2400985A2 (en) 2009-02-25 2012-01-04 OSI Pharmaceuticals, LLC Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US20110217309A1 (en) 2010-03-03 2011-09-08 Buck Elizabeth A Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
EP2519826A2 (en) 2010-03-03 2012-11-07 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
WO2011112666A1 (en) 2010-03-09 2011-09-15 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
WO2012116040A1 (en) 2011-02-22 2012-08-30 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
EP2702173A1 (en) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US9834575B2 (en) 2013-02-26 2017-12-05 Triact Therapeutics, Inc. Cancer therapy
EP3044593A4 (en) 2013-09-09 2017-05-17 Triact Therapeutics, Inc. Cancer therapy

Also Published As

Publication number Publication date
ES2283744T3 (es) 2007-11-01
WO2003068265A1 (en) 2003-08-21
CN100591355C (zh) 2010-02-24
CN1630534A (zh) 2005-06-22
DE60313434D1 (de) 2007-06-06
AU2003205768A1 (en) 2003-09-04
EP1476192B1 (en) 2007-04-25
DE60313434T2 (de) 2008-01-10
BR0307629A (pt) 2005-01-11
EP1476192A1 (en) 2004-11-17
JP2005517040A (ja) 2005-06-09
PT1476192E (pt) 2007-07-26
ATE360442T1 (de) 2007-05-15
CA2476000A1 (en) 2003-08-21

Similar Documents

Publication Publication Date Title
JP5053503B2 (ja) 過増殖状態を処置するための方法および組成物
US8119649B2 (en) Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia
JP6247249B2 (ja) 眼障害のためのpde1阻害剤
CN101415424B (zh) 用于治疗癌症、包含bcr-abl/c-kit/pdgf-r tk抑制剂的组合
JP2020533332A (ja) 障害を処置するためのcxcr−2阻害剤
US20060074078A1 (en) Product comprising a transduction inhibitor of heterotrimeric G protein signals combined with another anti-cancer agent for therapeutic use in the treatment of cancer
US20050215564A1 (en) Methods and compositions for treating hyperproliferative conditions
JP2013127001A (ja) ピリミジルアミノベンズアミド化合物であるタンパク質キナーゼ阻害剤および17−aagのようなhsp90阻害剤を含む組合せ剤
JP2002517443A (ja) Hivプロテアーゼ阻害剤の浸透を増加させる方法および組成物
CN101443002A (zh) 包含铁螯合剂和抗肿瘤药的组合及其用途
JP2009532497A (ja) 癌を処置するための治療剤の組合せ
JP2007513967A (ja) 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
CN114728003B (zh) 治疗b细胞恶性肿瘤的阿卡替尼和卡帕塞替尼的治疗组合
JP2002526449A (ja) ラミブジンおよびアバカビルを含んでなる抗ウイルス性組合せ製剤
HK1146804A (en) Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia
ZA200306404B (en) Combination comprising a signal transduction inhibitor and an epothilone derivative.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060207

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060207

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090519

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090819

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090924

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120726

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150803

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees