JP5024866B2 - 創傷治癒のためのマトリックスタンパク質組成物 - Google Patents

創傷治癒のためのマトリックスタンパク質組成物 Download PDF

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Publication number
JP5024866B2
JP5024866B2 JP2007131100A JP2007131100A JP5024866B2 JP 5024866 B2 JP5024866 B2 JP 5024866B2 JP 2007131100 A JP2007131100 A JP 2007131100A JP 2007131100 A JP2007131100 A JP 2007131100A JP 5024866 B2 JP5024866 B2 JP 5024866B2
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Prior art keywords
enamel matrix
enamel
composition
composition according
protein
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2007131100A
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English (en)
Japanese (ja)
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JP2007291115A5 (enExample
JP2007291115A6 (ja
JP2007291115A (ja
Inventor
スティナ ゲストレリウス
ラルス ハンマーストローム
ペーター リンスタッダス
クライスター アンダーソン
イワン スラビー
トマス ハンマーグレン
Original Assignee
ストローマン ホールディング アーゲー
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Publication of JP2007291115A5 publication Critical patent/JP2007291115A5/ja
Publication of JP2007291115A6 publication Critical patent/JP2007291115A6/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Virology (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007131100A 1998-02-27 2007-05-17 創傷治癒のためのマトリックスタンパク質組成物 Expired - Lifetime JP5024866B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK0270/98 1998-02-27
DK27098 1998-02-27
US8155198P 1998-04-13 1998-04-13
US60/081,551 1998-04-13
DKPA199801328 1998-10-16
DKPA199801328 1998-10-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000533139A Division JP4726296B2 (ja) 1998-02-27 1999-02-26 創傷治癒のためのマトリックスタンパク質組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011000082A Division JP5227428B2 (ja) 1998-02-27 2011-01-04 創傷治癒のためのマトリックスタンパク質組成物

Publications (4)

Publication Number Publication Date
JP2007291115A JP2007291115A (ja) 2007-11-08
JP2007291115A5 JP2007291115A5 (enExample) 2008-02-07
JP2007291115A6 JP2007291115A6 (ja) 2008-04-03
JP5024866B2 true JP5024866B2 (ja) 2012-09-12

Family

ID=27220558

Family Applications (2)

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JP2007131100A Expired - Lifetime JP5024866B2 (ja) 1998-02-27 2007-05-17 創傷治癒のためのマトリックスタンパク質組成物
JP2011000082A Expired - Lifetime JP5227428B2 (ja) 1998-02-27 2011-01-04 創傷治癒のためのマトリックスタンパク質組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011000082A Expired - Lifetime JP5227428B2 (ja) 1998-02-27 2011-01-04 創傷治癒のためのマトリックスタンパク質組成物

Country Status (18)

Country Link
EP (2) EP1153610B1 (enExample)
JP (2) JP5024866B2 (enExample)
KR (1) KR20010041408A (enExample)
CN (1) CN1248734C (enExample)
AT (2) ATE220918T1 (enExample)
AU (1) AU740468B2 (enExample)
BR (1) BR9908182A (enExample)
CA (2) CA2322215C (enExample)
DE (2) DE69910622T2 (enExample)
DK (2) DK1153610T3 (enExample)
ES (2) ES2183510T3 (enExample)
HU (1) HUP0101710A2 (enExample)
IL (1) IL137869A0 (enExample)
IS (1) IS5591A (enExample)
NO (1) NO20004282L (enExample)
PL (1) PL202536B1 (enExample)
SK (1) SK12362000A3 (enExample)
WO (1) WO1999043344A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096740A1 (en) 1999-03-10 2003-05-22 Lars Hammarstrom Matrix protein compositions for induction of apoptosis
US7304030B2 (en) 2000-06-20 2007-12-04 Biora Ab Matrix protein composition for dentin regeneration
AU2001274374A1 (en) * 2000-06-20 2002-01-02 Biora Ab Matrix protein compositions for dentin regeneration
US7033611B2 (en) 2001-02-23 2006-04-25 Biora Bioex Ab Matrix protein compositions for guided connective tissue growth
CA2438084C (en) * 2001-02-23 2011-02-15 Biora Bioex Ab Matrix protein compositions for guided connective tissue growth
MXPA04002348A (es) * 2001-09-14 2004-09-28 Biora Bioex Ab Composiciones de proteina de matriz de esmalte para modular respuesta inmune.
KR100934411B1 (ko) 2001-09-14 2009-12-29 바이오라 바이오엑스 에이비 면역반응을 조절하기 위한 에나멜 기질 단백질 조성물
KR100450146B1 (ko) * 2002-02-19 2004-09-30 정필훈 발치된 치아로부터 치아 단백질의 추출방법과 그의이용방법
KR101123113B1 (ko) * 2002-07-29 2012-03-15 쎄라피콘 에스.알.엘. 코 펩티드 약학 제형
JP2004307454A (ja) 2003-02-21 2004-11-04 Seikagaku Kogyo Co Ltd 生理活性ペプチド及びこれを含有する薬剤
EP1830863A2 (en) 2004-12-10 2007-09-12 Straumann Holding AG Protein formulation
EP1862170B1 (en) * 2004-12-10 2012-03-14 Straumann Holding AG Enamel formulation with amelogenin
SE0403014D0 (sv) 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
US7771751B2 (en) 2005-08-31 2010-08-10 Abraxis Bioscience, Llc Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
WO2010107794A2 (en) * 2009-03-16 2010-09-23 University Of Memphis Research Foundation Compositions and methods for delivering an agent to a wound
US8466101B2 (en) 2009-11-02 2013-06-18 Straumann Holding Ag Purified EMD protein composition
WO2011073447A1 (en) 2009-12-18 2011-06-23 Straumann Holding Ag Emd c-depleted
GB0922438D0 (en) 2009-12-22 2010-02-03 Ucl Business Plc Agents having tissue generative activity
CA2801332C (en) 2010-10-15 2016-08-23 Straumann Holding Ag New emd formulation comprising pga
US20120294898A1 (en) * 2011-05-19 2012-11-22 Warsaw Orthopedic, Inc. Injectable dbm for soft tissue repair
EP2687224A1 (en) * 2012-07-19 2014-01-22 Tissue Med Biosciences Forschungs- und Entwicklungsgesellschaft mbH Medicament for wound treatment
SE536581C2 (sv) 2012-07-24 2014-03-11 Rls Global Ab Ett kit för behandling av sår eller liknande och ett preparat och metoder därav
CN112915281B (zh) * 2021-03-12 2022-12-16 臻叶生物科技有限公司 一种无抗凝剂的prp生物膜制备装置及方法
CN117138105B (zh) * 2023-09-26 2025-11-11 邯郸惠科新材料科技有限公司 一种液体创口贴及其制备方法
EP4656213A1 (en) * 2024-05-27 2025-12-03 Institut Straumann AG Injectable compositions of emd fraction b

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454480B (sv) * 1986-09-25 1988-05-09 Lars Hammarstrom Bindningsinducerande komposition
SE461313B (sv) * 1988-03-17 1990-02-05 Biora Ab Bindningsinducerande komposition
PL324518A1 (en) * 1995-07-13 1998-06-08 Biora Ab Polypeptide showing affinity to enamel matrix
JP4726296B2 (ja) * 1998-02-27 2011-07-20 インスティチュート ストローマン アーゲー 創傷治癒のためのマトリックスタンパク質組成物

Also Published As

Publication number Publication date
DE69902234T2 (de) 2003-03-27
DE69910622T2 (de) 2004-06-17
EP1059934B1 (en) 2002-07-24
HK1030880A1 (en) 2001-05-25
EP1153610A1 (en) 2001-11-14
DE69910622D1 (de) 2003-09-25
PL202536B1 (pl) 2009-07-31
IL137869A0 (en) 2001-10-31
PL343375A1 (en) 2001-08-13
SK12362000A3 (sk) 2001-04-09
JP5227428B2 (ja) 2013-07-03
ATE220918T1 (de) 2002-08-15
NO20004282L (no) 2000-10-27
CA2322215C (en) 2010-12-21
KR20010041408A (ko) 2001-05-15
EP1153610B1 (en) 2003-08-20
ES2204804T3 (es) 2004-05-01
AU2436899A (en) 1999-09-15
CN1297356A (zh) 2001-05-30
BR9908182A (pt) 2001-11-13
ES2183510T3 (es) 2003-03-16
JP2011088927A (ja) 2011-05-06
CA2322215A1 (en) 1999-09-02
DE69902234D1 (de) 2002-08-29
DK1153610T3 (da) 2003-12-08
IS5591A (is) 2000-08-18
CN1248734C (zh) 2006-04-05
NO20004282D0 (no) 2000-08-25
CA2640994C (en) 2013-07-09
DK1059934T3 (da) 2002-11-11
CA2640994A1 (en) 1999-09-02
HUP0101710A2 (hu) 2001-09-28
ATE247483T1 (de) 2003-09-15
WO1999043344A3 (en) 1999-11-25
AU740468B2 (en) 2001-11-08
EP1059934A2 (en) 2000-12-20
JP2007291115A (ja) 2007-11-08
WO1999043344A2 (en) 1999-09-02

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