JP5000521B2 - 脱保護の方法 - Google Patents
脱保護の方法 Download PDFInfo
- Publication number
- JP5000521B2 JP5000521B2 JP2007534071A JP2007534071A JP5000521B2 JP 5000521 B2 JP5000521 B2 JP 5000521B2 JP 2007534071 A JP2007534071 A JP 2007534071A JP 2007534071 A JP2007534071 A JP 2007534071A JP 5000521 B2 JP5000521 B2 JP 5000521B2
- Authority
- JP
- Japan
- Prior art keywords
- fdg
- protected
- acid
- compound
- deprotection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0422004.2 | 2004-10-05 | ||
| GBGB0422004.2A GB0422004D0 (en) | 2004-10-05 | 2004-10-05 | Method of deprotection |
| PCT/GB2005/003692 WO2006037950A1 (en) | 2004-10-05 | 2005-09-23 | Method of deprotection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515793A JP2008515793A (ja) | 2008-05-15 |
| JP2008515793A5 JP2008515793A5 (https=) | 2008-11-06 |
| JP5000521B2 true JP5000521B2 (ja) | 2012-08-15 |
Family
ID=33428035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534071A Expired - Fee Related JP5000521B2 (ja) | 2004-10-05 | 2005-09-23 | 脱保護の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7714115B2 (https=) |
| EP (1) | EP1797029A1 (https=) |
| JP (1) | JP5000521B2 (https=) |
| CN (1) | CN101035755B (https=) |
| GB (1) | GB0422004D0 (https=) |
| WO (1) | WO2006037950A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070260267A1 (en) * | 2002-10-07 | 2007-11-08 | Nicoson Zachary R | Localizing obturator |
| PL2106808T3 (pl) * | 2006-12-21 | 2018-07-31 | Nihon Medi-Physics Co., Ltd. | Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy |
| KR101408727B1 (ko) | 2006-12-27 | 2014-06-17 | 니혼 메디피직스 가부시키가이샤 | 방사성 할로겐 표식 유기 화합물의 전구체 화합물의 제조 방법 |
| TWI406674B (zh) * | 2007-02-13 | 2013-09-01 | 日本藥學物理公司 | Method for manufacturing diagnostic radiographic diagnostic agents |
| EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
| US8043316B2 (en) | 2008-05-02 | 2011-10-25 | Suros Surgical Systems, Inc. | Adjustable spacer |
| GB0905515D0 (en) * | 2009-03-31 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling methods |
| AU2010321278B2 (en) * | 2009-11-17 | 2014-08-14 | Piramal Imaging Sa | Method for production of F-18 labeled glutamic acid derivatives |
| WO2011157443A1 (en) * | 2010-06-17 | 2011-12-22 | N.V. Organon | (11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one |
| CA2823063C (en) * | 2010-12-29 | 2020-08-11 | Ge Healthcare Limited | A method for preparation of f for use in a radiofluorination reaction |
| US9101895B2 (en) | 2011-04-15 | 2015-08-11 | General Electric Company | System for mixing and dispersing microbubble pharmaceuticals |
| KR101221483B1 (ko) * | 2011-05-13 | 2013-01-16 | 서강대학교산학협력단 | Ｆ-18 표지 방사성의약품 합성 장치 및 방법 |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| KR20140102700A (ko) * | 2011-12-21 | 2014-08-22 | 지이 헬쓰케어 리미티드 | 시트레이트 완충제 내 18ｆ―플루시클로빈 조성물 |
| WO2015188165A1 (en) * | 2014-06-06 | 2015-12-10 | The Regents Of The University Of California | Self-shielded, benchtop chemistry system |
| HUE069964T2 (hu) * | 2016-06-10 | 2025-04-28 | Univ Johns Hopkins | Javított eljárás a radiojelölt prosztata-specifikus membrán antigén (prostate-specific membrane antigen, psma) gátló [18f]DCFPyL elõállítására |
| EP3551232B1 (en) * | 2016-12-07 | 2022-03-23 | Università degli Studi di Bari "Aldo Moro" | Stable f-dopa formulations and uses thereof |
| JP7159157B2 (ja) * | 2017-06-23 | 2022-10-24 | 日本メジフィジックス株式会社 | 放射性フッ素標識化合物の製造方法および放射性医薬の製造方法 |
| JPWO2022196734A1 (https=) * | 2021-03-17 | 2022-09-22 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135683A (en) | 1991-03-28 | 1992-08-04 | Arco Chemical Technology, L.P. | Process for producing a deprotected alkoxylated polyol |
| US5393908A (en) * | 1992-06-25 | 1995-02-28 | Satyamurthy; Nagichettiar | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa |
| DE4330889C2 (de) * | 1993-09-11 | 2002-10-31 | Emtec Magnetics Gmbh | Verfahren zur Wiedergewinnung von Rohmaterialien aus magnetischen Aufzeichnungsträgern |
| US5922810A (en) | 1995-07-31 | 1999-07-13 | Fmc Corporation | Deprotection of protected functional polymers |
| BE1010280A3 (fr) | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| DE10104250A1 (de) | 2001-01-31 | 2002-08-14 | Deutsches Krebsforsch | Markierungsfähige Verbindungen zur einfachen Synthese von 3'-[18F]Fluor-3'-deoxythymidin und Verfahren zu deren Herstellung |
| EP1356827A1 (en) * | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
| US7022872B2 (en) | 2003-12-19 | 2006-04-04 | Molecular Technologies, Inc. | Method for making fluorine labeled L-Dopa |
-
2004
- 2004-10-05 GB GBGB0422004.2A patent/GB0422004D0/en not_active Ceased
-
2005
- 2005-09-23 EP EP05784549A patent/EP1797029A1/en not_active Withdrawn
- 2005-09-23 CN CN2005800338074A patent/CN101035755B/zh not_active Expired - Fee Related
- 2005-09-23 US US11/576,625 patent/US7714115B2/en not_active Expired - Fee Related
- 2005-09-23 JP JP2007534071A patent/JP5000521B2/ja not_active Expired - Fee Related
- 2005-09-23 WO PCT/GB2005/003692 patent/WO2006037950A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101035755A (zh) | 2007-09-12 |
| US20080076914A1 (en) | 2008-03-27 |
| CN101035755B (zh) | 2011-12-21 |
| US7714115B2 (en) | 2010-05-11 |
| EP1797029A1 (en) | 2007-06-20 |
| JP2008515793A (ja) | 2008-05-15 |
| WO2006037950A1 (en) | 2006-04-13 |
| GB0422004D0 (en) | 2004-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
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| A521 | Request for written amendment filed |
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| TRDD | Decision of grant or rejection written | ||
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| R150 | Certificate of patent or registration of utility model |
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| FPAY | Renewal fee payment (event date is renewal date of database) |
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| LAPS | Cancellation because of no payment of annual fees |