CN101035755B - 脱保护的方法 - Google Patents

脱保护的方法 Download PDF

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Publication number
CN101035755B
CN101035755B CN2005800338074A CN200580033807A CN101035755B CN 101035755 B CN101035755 B CN 101035755B CN 2005800338074 A CN2005800338074 A CN 2005800338074A CN 200580033807 A CN200580033807 A CN 200580033807A CN 101035755 B CN101035755 B CN 101035755B
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China
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protected
acid
deprotection
method described
agent
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Expired - Fee Related
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CN2005800338074A
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English (en)
Chinese (zh)
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CN101035755A (zh
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J·格里格
N·奥斯博恩
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN2005800338074A 2004-10-05 2005-09-23 脱保护的方法 Expired - Fee Related CN101035755B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0422004.2 2004-10-05
GBGB0422004.2A GB0422004D0 (en) 2004-10-05 2004-10-05 Method of deprotection
PCT/GB2005/003692 WO2006037950A1 (en) 2004-10-05 2005-09-23 Method of deprotection

Publications (2)

Publication Number Publication Date
CN101035755A CN101035755A (zh) 2007-09-12
CN101035755B true CN101035755B (zh) 2011-12-21

Family

ID=33428035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800338074A Expired - Fee Related CN101035755B (zh) 2004-10-05 2005-09-23 脱保护的方法

Country Status (6)

Country Link
US (1) US7714115B2 (https=)
EP (1) EP1797029A1 (https=)
JP (1) JP5000521B2 (https=)
CN (1) CN101035755B (https=)
GB (1) GB0422004D0 (https=)
WO (1) WO2006037950A1 (https=)

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Publication number Priority date Publication date Assignee Title
US20070260267A1 (en) * 2002-10-07 2007-11-08 Nicoson Zachary R Localizing obturator
PL2106808T3 (pl) * 2006-12-21 2018-07-31 Nihon Medi-Physics Co., Ltd. Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy
KR101408727B1 (ko) 2006-12-27 2014-06-17 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물의 제조 방법
TWI406674B (zh) * 2007-02-13 2013-09-01 日本藥學物理公司 Method for manufacturing diagnostic radiographic diagnostic agents
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
US8043316B2 (en) 2008-05-02 2011-10-25 Suros Surgical Systems, Inc. Adjustable spacer
GB0905515D0 (en) * 2009-03-31 2009-05-13 Ge Healthcare Ltd Radiolabelling methods
AU2010321278B2 (en) * 2009-11-17 2014-08-14 Piramal Imaging Sa Method for production of F-18 labeled glutamic acid derivatives
WO2011157443A1 (en) * 2010-06-17 2011-12-22 N.V. Organon (11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
CA2823063C (en) * 2010-12-29 2020-08-11 Ge Healthcare Limited A method for preparation of f for use in a radiofluorination reaction
US9101895B2 (en) 2011-04-15 2015-08-11 General Electric Company System for mixing and dispersing microbubble pharmaceuticals
KR101221483B1 (ko) * 2011-05-13 2013-01-16 서강대학교산학협력단 Ｆ-18 표지 방사성의약품 합성 장치 및 방법
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
KR20140102700A (ko) * 2011-12-21 2014-08-22 지이 헬쓰케어 리미티드 시트레이트 완충제 내 18ｆ―플루시클로빈 조성물
WO2015188165A1 (en) * 2014-06-06 2015-12-10 The Regents Of The University Of California Self-shielded, benchtop chemistry system
HUE069964T2 (hu) * 2016-06-10 2025-04-28 Univ Johns Hopkins Javított eljárás a radiojelölt prosztata-specifikus membrán antigén (prostate-specific membrane antigen, psma) gátló [18f]DCFPyL elõállítására
EP3551232B1 (en) * 2016-12-07 2022-03-23 Università degli Studi di Bari "Aldo Moro" Stable f-dopa formulations and uses thereof
JP7159157B2 (ja) * 2017-06-23 2022-10-24 日本メジフィジックス株式会社 放射性フッ素標識化合物の製造方法および放射性医薬の製造方法
JPWO2022196734A1 (https=) * 2021-03-17 2022-09-22

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US5135683A (en) 1991-03-28 1992-08-04 Arco Chemical Technology, L.P. Process for producing a deprotected alkoxylated polyol
US5393908A (en) * 1992-06-25 1995-02-28 Satyamurthy; Nagichettiar Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa
DE4330889C2 (de) * 1993-09-11 2002-10-31 Emtec Magnetics Gmbh Verfahren zur Wiedergewinnung von Rohmaterialien aus magnetischen Aufzeichnungsträgern
US5922810A (en) 1995-07-31 1999-07-13 Fmc Corporation Deprotection of protected functional polymers
BE1010280A3 (fr) 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
DE10104250A1 (de) 2001-01-31 2002-08-14 Deutsches Krebsforsch Markierungsfähige Verbindungen zur einfachen Synthese von 3'-[18F]Fluor-3'-deoxythymidin und Verfahren zu deren Herstellung
EP1356827A1 (en) * 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
US7022872B2 (en) 2003-12-19 2006-04-04 Molecular Technologies, Inc. Method for making fluorine labeled L-Dopa

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Bryan Li 等.Aqueous phosphoric acid as a mild reagent fordeprotection of the t-butoxycarbonyl group,8113-8115.Tetrahedron Letters44 44.2003,44(44),表一. *
BryanLi等.Aqueousphosphoricacidasamildreagentfordeprotectionofthet-butoxycarbonylgroup 8113-8115.Tetrahedron Letters44 44.2003
K. Hamacher等.Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using AminopolyetherSupported Nucleophilic Substitution,235-238.J. Nucl. Med.27 2.1986,34(2),全文.
K. Hamacher等.Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using AminopolyetherSupported Nucleophilic Substitution,235-238.J. Nucl. Med.27 2.1986,34(2),全文. *
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Also Published As

Publication number Publication date
CN101035755A (zh) 2007-09-12
US20080076914A1 (en) 2008-03-27
US7714115B2 (en) 2010-05-11
EP1797029A1 (en) 2007-06-20
JP2008515793A (ja) 2008-05-15
JP5000521B2 (ja) 2012-08-15
WO2006037950A1 (en) 2006-04-13
GB0422004D0 (en) 2004-11-03

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