JP4975443B2 - 抗血栓活性を有する低分子量多糖 - Google Patents

抗血栓活性を有する低分子量多糖 Download PDF

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JP4975443B2
JP4975443B2 JP2006544586A JP2006544586A JP4975443B2 JP 4975443 B2 JP4975443 B2 JP 4975443B2 JP 2006544586 A JP2006544586 A JP 2006544586A JP 2006544586 A JP2006544586 A JP 2006544586A JP 4975443 B2 JP4975443 B2 JP 4975443B2
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Japan
Prior art keywords
lmw
sulfuric acid
depolymerization
epi
acid
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Expired - Fee Related
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JP2006544586A
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Japanese (ja)
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JP2007514817A (ja
Inventor
アンナ オレステ パスクア
ゾペッティ ジョルジオ
Original Assignee
グリコレス ２０００ ソシエタ ア レスポンサビリタ リミタータ
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
JP2006544586A 2003-12-17 2004-12-15 抗血栓活性を有する低分子量多糖 Expired - Fee Related JP4975443B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT002498A ITMI20032498A1 (it) 2003-12-17 2003-12-17 Polisaccaridi antitrombotici a basso peso molecolare e
ITMI2003A002498 2003-12-17
PCT/IB2004/004128 WO2005058976A2 (en) 2003-12-17 2004-12-15 Low molecular polysaccharides having antithrombotic activity

Publications (2)

Publication Number Publication Date
JP2007514817A JP2007514817A (ja) 2007-06-07
JP4975443B2 true JP4975443B2 (ja) 2012-07-11

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ID=34685622

Family Applications (1)

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JP2006544586A Expired - Fee Related JP4975443B2 (ja) 2003-12-17 2004-12-15 抗血栓活性を有する低分子量多糖

Country Status (9)

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US (1) US7812151B2 (US07812151-20101012-C00019.png)
EP (1) EP1694714B8 (US07812151-20101012-C00019.png)
JP (1) JP4975443B2 (US07812151-20101012-C00019.png)
AT (1) ATE388169T1 (US07812151-20101012-C00019.png)
DE (1) DE602004012314T2 (US07812151-20101012-C00019.png)
ES (1) ES2302065T3 (US07812151-20101012-C00019.png)
IT (1) ITMI20032498A1 (US07812151-20101012-C00019.png)
PT (1) PT1694714E (US07812151-20101012-C00019.png)
WO (1) WO2005058976A2 (US07812151-20101012-C00019.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
NZ537215A (en) * 2002-06-18 2006-11-30 Glycores 2000 S Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
EP1872791A1 (en) 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
WO2017115675A1 (ja) * 2015-12-28 2017-07-06 味の素株式会社 グルコサミン残基の３－ｏ－硫酸化率が高いヘパラン硫酸
CN110776578B (zh) * 2019-11-12 2021-01-29 苏州颐华生物医药技术股份有限公司 低分子海参糖胺聚糖及其应用
CN111875714B (zh) * 2020-08-05 2022-05-20 青岛海洋生物医药研究院股份有限公司 低分子量硫酸半乳聚糖及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141483B (it) 1980-04-18 1986-10-01 Crinos Industria Farmaco Resina poliamminica per la separazione selettiva di eparina da altri glucosamminoglicani e procedimento per la sua preparazione
ES2059321T3 (es) 1986-05-16 1994-11-16 Italfarmaco Spa Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1289613B1 (it) 1997-02-07 1998-10-15 Inalco Spa Polisaccaridi batterici o-solfatati
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
US20050027117A1 (en) 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20011633A1 (it) 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
ITMI20012200A1 (it) 2001-10-22 2003-04-22 Ibsa Inst Biochimique Sa Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti
NZ537215A (en) * 2002-06-18 2006-11-30 Glycores 2000 S Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
ITMI20032614A1 (it) 2003-12-30 2005-06-30 Altergon Sa Nuova composizione comprendente cs

Also Published As

Publication number Publication date
WO2005058976A2 (en) 2005-06-30
DE602004012314T2 (de) 2009-03-19
EP1694714B1 (en) 2008-03-05
ITMI20032498A1 (it) 2005-06-18
PT1694714E (pt) 2008-05-09
EP1694714A2 (en) 2006-08-30
WO2005058976A3 (en) 2005-08-04
ATE388169T1 (de) 2008-03-15
US20070155694A1 (en) 2007-07-05
DE602004012314D1 (de) 2008-04-17
EP1694714B8 (en) 2009-04-01
ES2302065T3 (es) 2008-07-01
JP2007514817A (ja) 2007-06-07
US7812151B2 (en) 2010-10-12

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