JP4918209B2 - アミノアルケニルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物 - Google Patents

アミノアルケニルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物 Download PDF

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Publication number
JP4918209B2
JP4918209B2 JP2002521439A JP2002521439A JP4918209B2 JP 4918209 B2 JP4918209 B2 JP 4918209B2 JP 2002521439 A JP2002521439 A JP 2002521439A JP 2002521439 A JP2002521439 A JP 2002521439A JP 4918209 B2 JP4918209 B2 JP 4918209B2
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Japan
Prior art keywords
group
benzofuran
compound
general formula
formula
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Expired - Fee Related
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JP2002521439A
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Japanese (ja)
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JP2004506726A (ja
Inventor
アサン，ジャン−ルイ
ベルナール，クロード
カバネル−オドリクール，フレデリク
サントス，ヴィクトル ドス
ゴティエ，パトリック
ニザト，ディノ
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2002521439A 2000-08-23 2001-08-23 アミノアルケニルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物 Expired - Fee Related JP4918209B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR00/10835 2000-08-23
FR0010835A FR2813307B1 (fr) 2000-08-23 2000-08-23 Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
PCT/FR2001/002656 WO2002016338A1 (fr) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (2)

Publication Number Publication Date
JP2004506726A JP2004506726A (ja) 2004-03-04
JP4918209B2 true JP4918209B2 (ja) 2012-04-18

Family

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Family Applications (1)

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JP2002521439A Expired - Fee Related JP4918209B2 (ja) 2000-08-23 2001-08-23 アミノアルケニルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物

Country Status (25)

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US (1) US6946483B2 (US06946483-20050920-C00005.png)
EP (1) EP1315708B1 (US06946483-20050920-C00005.png)
JP (1) JP4918209B2 (US06946483-20050920-C00005.png)
KR (1) KR20030023768A (US06946483-20050920-C00005.png)
CN (1) CN1471519A (US06946483-20050920-C00005.png)
AT (1) ATE273293T1 (US06946483-20050920-C00005.png)
AU (1) AU2001284154A1 (US06946483-20050920-C00005.png)
BG (1) BG107553A (US06946483-20050920-C00005.png)
BR (1) BR0113350A (US06946483-20050920-C00005.png)
CA (1) CA2415846A1 (US06946483-20050920-C00005.png)
CZ (1) CZ2003520A3 (US06946483-20050920-C00005.png)
DE (1) DE60104866T2 (US06946483-20050920-C00005.png)
EA (1) EA200300063A1 (US06946483-20050920-C00005.png)
FR (1) FR2813307B1 (US06946483-20050920-C00005.png)
HU (1) HUP0302892A3 (US06946483-20050920-C00005.png)
IL (1) IL153637A0 (US06946483-20050920-C00005.png)
IS (1) IS6676A (US06946483-20050920-C00005.png)
MA (1) MA26944A1 (US06946483-20050920-C00005.png)
MX (1) MXPA03001592A (US06946483-20050920-C00005.png)
NO (1) NO20030801L (US06946483-20050920-C00005.png)
OA (1) OA12358A (US06946483-20050920-C00005.png)
PL (1) PL362123A1 (US06946483-20050920-C00005.png)
SK (1) SK2112003A3 (US06946483-20050920-C00005.png)
WO (1) WO2002016338A1 (US06946483-20050920-C00005.png)
ZA (1) ZA200300746B (US06946483-20050920-C00005.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG173014A1 (en) 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN107935972B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用
CN107857748B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
CN107827849B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
JPH0242073A (ja) * 1988-04-18 1990-02-13 Taro Pharmaceut Ind Ltd ２―アルキル―３―ベンゾイルベンゾフラン類及びそれらを含有する医薬組成物
JPH04316554A (ja) * 1990-08-06 1992-11-06 Sanofi Sa ベンゾフラン、ベンゾチオフェン、インドールおよびインドリジン誘導体、製法および組成物
US5827876A (en) * 1996-04-09 1998-10-27 American Home Products Corporation Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
CA2220991A1 (en) * 1995-06-26 1997-01-16 Eli Lilly And Company Benzothiophene compounds
AU3171099A (en) * 1998-04-17 1999-11-08 Senga Pharmaceutical Laboratory Inc. 1-heteroindene derivatives and medicinal composition containing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
JPH0242073A (ja) * 1988-04-18 1990-02-13 Taro Pharmaceut Ind Ltd ２―アルキル―３―ベンゾイルベンゾフラン類及びそれらを含有する医薬組成物
JPH04316554A (ja) * 1990-08-06 1992-11-06 Sanofi Sa ベンゾフラン、ベンゾチオフェン、インドールおよびインドリジン誘導体、製法および組成物
US5827876A (en) * 1996-04-09 1998-10-27 American Home Products Corporation Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes

Also Published As

Publication number Publication date
CN1471519A (zh) 2004-01-28
HUP0302892A2 (hu) 2003-12-29
EP1315708B1 (fr) 2004-08-11
US6946483B2 (en) 2005-09-20
DE60104866D1 (de) 2004-09-16
ATE273293T1 (de) 2004-08-15
CZ2003520A3 (cs) 2003-05-14
ZA200300746B (en) 2004-02-10
MA26944A1 (fr) 2004-12-20
EP1315708A1 (fr) 2003-06-04
SK2112003A3 (en) 2003-08-05
US20030187060A1 (en) 2003-10-02
WO2002016338A1 (fr) 2002-02-28
WO2002016338A8 (fr) 2002-05-10
AU2001284154A1 (en) 2002-03-04
EA200300063A1 (ru) 2003-08-28
HUP0302892A3 (en) 2005-02-28
NO20030801D0 (no) 2003-02-20
IS6676A (is) 2003-01-13
BG107553A (en) 2004-01-30
JP2004506726A (ja) 2004-03-04
BR0113350A (pt) 2003-07-08
IL153637A0 (en) 2003-07-06
KR20030023768A (ko) 2003-03-19
OA12358A (fr) 2006-05-16
MXPA03001592A (es) 2003-09-10
NO20030801L (no) 2003-04-23
CA2415846A1 (fr) 2002-02-28
PL362123A1 (en) 2004-10-18
DE60104866T2 (de) 2005-10-20
FR2813307B1 (fr) 2002-11-08
FR2813307A1 (fr) 2002-03-01

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