JP4900587B2 - ヒト胚幹細胞由来の最終分化ドーパミン作動性神経細胞の誘導 - Google Patents
ヒト胚幹細胞由来の最終分化ドーパミン作動性神経細胞の誘導 Download PDFInfo
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- JP4900587B2 JP4900587B2 JP2006506517A JP2006506517A JP4900587B2 JP 4900587 B2 JP4900587 B2 JP 4900587B2 JP 2006506517 A JP2006506517 A JP 2006506517A JP 2006506517 A JP2006506517 A JP 2006506517A JP 4900587 B2 JP4900587 B2 JP 4900587B2
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN269MU2003 | 2003-03-12 | ||
| IN269/MUM/2003 | 2003-03-12 | ||
| US52004803P | 2003-11-14 | 2003-11-14 | |
| US60/520,048 | 2003-11-14 | ||
| PCT/IB2004/001246 WO2004081172A2 (en) | 2003-03-12 | 2004-03-11 | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035457A Division JP2010187669A (ja) | 2003-03-12 | 2010-02-19 | ヒト胚幹細胞由来の最終分化ドーパミン作動性神経細胞の誘導 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006521807A JP2006521807A (ja) | 2006-09-28 |
| JP2006521807A5 JP2006521807A5 (enExample) | 2010-04-08 |
| JP4900587B2 true JP4900587B2 (ja) | 2012-03-21 |
Family
ID=34074054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006506517A Expired - Fee Related JP4900587B2 (ja) | 2003-03-12 | 2004-03-11 | ヒト胚幹細胞由来の最終分化ドーパミン作動性神経細胞の誘導 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4900587B2 (enExample) |
| CN (1) | CN1894401B (enExample) |
| ZA (1) | ZA200401646B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009148170A1 (ja) * | 2008-06-06 | 2009-12-10 | 独立行政法人理化学研究所 | 幹細胞の培養方法 |
| EP2356450B1 (en) * | 2008-10-24 | 2019-02-06 | B.R.A.H.M.S GmbH | Prognosis and risk assessment in stroke patients by determining the level of marker peptides |
| CN101824399B (zh) * | 2009-03-05 | 2012-05-30 | 中日友好医院 | 从人羊膜上皮细胞中诱导分化出多巴胺能神经元的方法及分离所得神经元的用途 |
| CN101824398B (zh) * | 2009-03-05 | 2012-08-08 | 中日友好医院 | 人羊膜上皮细胞与神经干细胞共培养诱导分化多巴胺能神经元的方法 |
| WO2011055855A1 (en) | 2009-11-05 | 2011-05-12 | Riken | A method for differentiation induction in cultured stem cells |
| WO2011108766A1 (en) * | 2010-03-03 | 2011-09-09 | Kyoto University | METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM iPS CELLS |
| CN110684734A (zh) * | 2011-11-04 | 2020-01-14 | 纪念斯隆-凯特琳癌症中心 | 用于植入的中脑多巴胺(da)神经元 |
| KR102073111B1 (ko) * | 2012-10-16 | 2020-02-04 | 메르츠 파마 게엠베하 운트 코. 카가아 | 신경독소 폴리펩티드의 생물학적 활성의 결정을 위한 세포 테스트 시스템 |
| SG11201601720RA (en) * | 2013-09-05 | 2016-04-28 | Univ Kyoto | New method for inducing dopamine-producing neural precursor cells |
| ES2972541T3 (es) * | 2014-09-08 | 2024-06-13 | Riken | Método para producir tejido progenitor cerebeloso |
| CN105087475B (zh) * | 2015-09-17 | 2018-12-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种细胞培养液及其应用以及诱导牙髓干细胞向神经样细胞分化的方法 |
| JP2018529389A (ja) * | 2015-10-08 | 2018-10-11 | ニューロナ セラピューティクス インコーポレイテッドNeurona Therapeutics Inc. | 神経前駆細胞集団およびそれらの使用 |
| US11898163B2 (en) | 2016-04-22 | 2024-02-13 | Kyoto University | Method for producing dopaminergic neuron progenitor cell |
| FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
| EP3551748B1 (en) * | 2016-12-12 | 2022-07-13 | Health and Biotech France (H&B France) | Perinatal tissue derived mesenchymal stem cells: method of preparation and uses thereof |
| WO2020054647A1 (ja) * | 2018-09-14 | 2020-03-19 | 学校法人慶應義塾 | アストロサイトの製造方法 |
| CN111304167B (zh) * | 2018-12-12 | 2024-03-26 | 上海泉眼生物科技有限公司 | 人源脂肪干细胞来源的神经元前体细胞及其制备方法和应用 |
| JP7209850B2 (ja) * | 2019-01-22 | 2023-01-20 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | 直接細胞転換に基づく神経幹細胞の星状膠細胞への分化方法 |
| CN114606188A (zh) * | 2019-03-06 | 2022-06-10 | 安徽中盛溯源生物科技有限公司 | 一种中脑多巴胺能神经前体细胞的制备方法及其应用 |
| CN110257332A (zh) * | 2019-07-08 | 2019-09-20 | 广东省赛莱拉干细胞研究院 | 一种诱导间充质干细胞分化成为多巴胺能神经元的培养基以及方法 |
| CN110669143B (zh) * | 2019-10-10 | 2021-05-14 | 中国人民解放军军事科学院军事医学研究院 | 一种短肽及其应用 |
| CN114657119B (zh) * | 2022-03-16 | 2023-10-20 | 广东省农业科学院动物科学研究所 | 一种初生仔猪肠神经胶质细胞的分离和原代培养方法 |
| CN115591025B (zh) * | 2022-11-09 | 2024-01-02 | 深圳先进技术研究院 | 神经调控器件、制备方法及其应用 |
| JP2025539432A (ja) | 2022-12-02 | 2025-12-05 | ナウェーセル バイオテクノロジーズ カンパニー リミテッド | 中脳ドーパミン作動性前駆細胞を成熟させるための培養培地、コーティングマトリックスおよび方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277820B1 (en) * | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
| US7250294B2 (en) * | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| AU2001263199B2 (en) * | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US20030036195A1 (en) * | 2001-04-20 | 2003-02-20 | Lorenz Studer | Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use |
-
2004
- 2004-03-01 ZA ZA200401646A patent/ZA200401646B/xx unknown
- 2004-03-11 JP JP2006506517A patent/JP4900587B2/ja not_active Expired - Fee Related
- 2004-03-11 CN CN2004800127488A patent/CN1894401B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200401646B (en) | 2004-06-07 |
| CN1894401A (zh) | 2007-01-10 |
| JP2006521807A (ja) | 2006-09-28 |
| CN1894401B (zh) | 2012-05-23 |
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