JP4892654B2 - デルタレセプターアゴニスト化合物によるうつ病の治療方法 - Google Patents
デルタレセプターアゴニスト化合物によるうつ病の治療方法 Download PDFInfo
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- JP4892654B2 JP4892654B2 JP2003539685A JP2003539685A JP4892654B2 JP 4892654 B2 JP4892654 B2 JP 4892654B2 JP 2003539685 A JP2003539685 A JP 2003539685A JP 2003539685 A JP2003539685 A JP 2003539685A JP 4892654 B2 JP4892654 B2 JP 4892654B2
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- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
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- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- DKJCUVXSBOMWAV-PCWWUVHHSA-N naltrindole Chemical compound N1([C@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC2=C3[CH]C=CC=C3N=C25)O)CC1)O)CC1CC1 DKJCUVXSBOMWAV-PCWWUVHHSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000006902 nitrogenation reaction Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229940098458 powder spray Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940035613 prozac Drugs 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 125000006413 ring segment Chemical group 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
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- 230000002393 scratching effect Effects 0.000 description 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 229940020965 zoloft Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
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| US34008401P | 2001-10-29 | 2001-10-29 | |
| US60/340,084 | 2001-10-29 | ||
| US33788701P | 2001-11-02 | 2001-11-02 | |
| US60/337,887 | 2001-11-02 | ||
| PCT/US2002/034421 WO2003037342A1 (en) | 2001-10-29 | 2002-10-29 | Method of treating depression with delta receptor agonist compounds |
Publications (3)
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| JP2005508363A JP2005508363A (ja) | 2005-03-31 |
| JP2005508363A5 JP2005508363A5 (enExample) | 2006-01-05 |
| JP4892654B2 true JP4892654B2 (ja) | 2012-03-07 |
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| Country | Link |
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| US (1) | US7030124B2 (enExample) |
| EP (1) | EP1450807B1 (enExample) |
| JP (1) | JP4892654B2 (enExample) |
| CN (1) | CN1596113B (enExample) |
| CA (1) | CA2464471C (enExample) |
| MX (1) | MXPA04004059A (enExample) |
| NO (1) | NO20042257L (enExample) |
| PL (1) | PL371297A1 (enExample) |
| RU (1) | RU2314809C2 (enExample) |
| TW (1) | TW200300089A (enExample) |
| WO (1) | WO2003037342A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE60230869D1 (de) * | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| HRP20120343T1 (hr) * | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP1874315A2 (en) * | 2005-04-14 | 2008-01-09 | Mount Cook Biosciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
| WO2007027987A2 (en) | 2005-09-02 | 2007-03-08 | Mount Cook Biosciences, Inc. | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| CN103467460A (zh) * | 2013-09-23 | 2013-12-25 | 昆明理工大学 | 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用 |
| CN105646151B (zh) * | 2016-02-26 | 2018-06-29 | 山西大学 | 一种炔类化合物及其制备方法和该化合物的用途 |
| US10973815B2 (en) | 2016-03-31 | 2021-04-13 | Versi Group, Llc | Delta opioid agonist mu opioid antagonist compositions and methods for treating Parkinsons disease |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07503247A (ja) * | 1992-02-03 | 1995-04-06 | デルタ ファーマソウティカルズ，インコーポレイテッド | オピオイドジアリールメチルピペラジンおよびピペリジン |
| JP2000513024A (ja) * | 1997-05-19 | 2000-10-03 | ファイザー・インク | 抗炎症性ピペラジニルベンジルテトラゾール誘導体とその中間体 |
| WO2001046263A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel compounds |
| WO2001046174A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel compounds |
| WO2001045637A2 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US20020052007A1 (en) | 1992-02-03 | 2002-05-02 | Chang Kwen Jen | Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| HU221726B1 (hu) * | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| EP0952154B1 (en) * | 1998-04-16 | 2004-08-18 | Pfizer Products Inc. | N-acyl and N-aroyl aralkyl amides |
| GB0017256D0 (en) * | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| DE60230869D1 (de) | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
-
2002
- 2002-10-29 WO PCT/US2002/034421 patent/WO2003037342A1/en not_active Ceased
- 2002-10-29 TW TW091132060A patent/TW200300089A/zh unknown
- 2002-10-29 CN CN028237099A patent/CN1596113B/zh not_active Expired - Fee Related
- 2002-10-29 RU RU2004115748/14A patent/RU2314809C2/ru not_active IP Right Cessation
- 2002-10-29 JP JP2003539685A patent/JP4892654B2/ja not_active Expired - Fee Related
- 2002-10-29 EP EP02789294.2A patent/EP1450807B1/en not_active Expired - Lifetime
- 2002-10-29 US US10/282,411 patent/US7030124B2/en not_active Expired - Fee Related
- 2002-10-29 PL PL02371297A patent/PL371297A1/xx unknown
- 2002-10-29 CA CA2464471A patent/CA2464471C/en not_active Expired - Fee Related
- 2002-10-29 MX MXPA04004059A patent/MXPA04004059A/es unknown
-
2004
- 2004-06-01 NO NO20042257A patent/NO20042257L/no not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07503247A (ja) * | 1992-02-03 | 1995-04-06 | デルタ ファーマソウティカルズ，インコーポレイテッド | オピオイドジアリールメチルピペラジンおよびピペリジン |
| JP2000513024A (ja) * | 1997-05-19 | 2000-10-03 | ファイザー・インク | 抗炎症性ピペラジニルベンジルテトラゾール誘導体とその中間体 |
| WO2001046263A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel compounds |
| WO2001046174A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel compounds |
| WO2001045637A2 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2464471A1 (en) | 2003-05-08 |
| US20030144299A1 (en) | 2003-07-31 |
| NO20042257L (no) | 2004-06-24 |
| CN1596113B (zh) | 2010-05-26 |
| EP1450807A1 (en) | 2004-09-01 |
| EP1450807A4 (en) | 2008-06-25 |
| PL371297A1 (en) | 2005-06-13 |
| WO2003037342A1 (en) | 2003-05-08 |
| CA2464471C (en) | 2012-05-15 |
| RU2004115748A (ru) | 2005-03-27 |
| JP2005508363A (ja) | 2005-03-31 |
| EP1450807B1 (en) | 2013-12-25 |
| CN1596113A (zh) | 2005-03-16 |
| US7030124B2 (en) | 2006-04-18 |
| RU2314809C2 (ru) | 2008-01-20 |
| MXPA04004059A (es) | 2005-03-31 |
| TW200300089A (en) | 2003-05-16 |
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