CN1596113B - δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 - Google Patents
δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 Download PDFInfo
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- CN1596113B CN1596113B CN028237099A CN02823709A CN1596113B CN 1596113 B CN1596113 B CN 1596113B CN 028237099 A CN028237099 A CN 028237099A CN 02823709 A CN02823709 A CN 02823709A CN 1596113 B CN1596113 B CN 1596113B
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- BXBUVIPNRGDTNE-UHFFFAOYSA-N sodium;hydrobromide Chemical compound [Na].Br BXBUVIPNRGDTNE-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 239000006208 topical dosage form Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34008401P | 2001-10-29 | 2001-10-29 | |
| US60/340,084 | 2001-10-29 | ||
| US33788701P | 2001-11-02 | 2001-11-02 | |
| US60/337,887 | 2001-11-02 | ||
| PCT/US2002/034421 WO2003037342A1 (en) | 2001-10-29 | 2002-10-29 | Method of treating depression with delta receptor agonist compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1596113A CN1596113A (zh) | 2005-03-16 |
| CN1596113B true CN1596113B (zh) | 2010-05-26 |
Family
ID=26990913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN028237099A Expired - Fee Related CN1596113B (zh) | 2001-10-29 | 2002-10-29 | δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7030124B2 (enExample) |
| EP (1) | EP1450807B1 (enExample) |
| JP (1) | JP4892654B2 (enExample) |
| CN (1) | CN1596113B (enExample) |
| CA (1) | CA2464471C (enExample) |
| MX (1) | MXPA04004059A (enExample) |
| NO (1) | NO20042257L (enExample) |
| PL (1) | PL371297A1 (enExample) |
| RU (1) | RU2314809C2 (enExample) |
| TW (1) | TW200300089A (enExample) |
| WO (1) | WO2003037342A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60230869D1 (de) * | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| HRP20120343T1 (hr) * | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP1874315A2 (en) * | 2005-04-14 | 2008-01-09 | Mount Cook Biosciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
| WO2007027987A2 (en) | 2005-09-02 | 2007-03-08 | Mount Cook Biosciences, Inc. | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| CN103467460A (zh) * | 2013-09-23 | 2013-12-25 | 昆明理工大学 | 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用 |
| CN105646151B (zh) * | 2016-02-26 | 2018-06-29 | 山西大学 | 一种炔类化合物及其制备方法和该化合物的用途 |
| US10973815B2 (en) | 2016-03-31 | 2021-04-13 | Versi Group, Llc | Delta opioid agonist mu opioid antagonist compositions and methods for treating Parkinsons disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658908A (en) * | 1992-02-03 | 1997-08-19 | Delta Pharmaceuticals, Inc. | Opioid diarylmethylpiperazines and piperdines |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US20020052007A1 (en) | 1992-02-03 | 2002-05-02 | Chang Kwen Jen | Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| HU221726B1 (hu) * | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| EP0952154B1 (en) * | 1998-04-16 | 2004-08-18 | Pfizer Products Inc. | N-acyl and N-aroyl aralkyl amides |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904675D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| GB0017256D0 (en) * | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| DE60230869D1 (de) | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
-
2002
- 2002-10-29 WO PCT/US2002/034421 patent/WO2003037342A1/en not_active Ceased
- 2002-10-29 TW TW091132060A patent/TW200300089A/zh unknown
- 2002-10-29 CN CN028237099A patent/CN1596113B/zh not_active Expired - Fee Related
- 2002-10-29 RU RU2004115748/14A patent/RU2314809C2/ru not_active IP Right Cessation
- 2002-10-29 JP JP2003539685A patent/JP4892654B2/ja not_active Expired - Fee Related
- 2002-10-29 EP EP02789294.2A patent/EP1450807B1/en not_active Expired - Lifetime
- 2002-10-29 US US10/282,411 patent/US7030124B2/en not_active Expired - Fee Related
- 2002-10-29 PL PL02371297A patent/PL371297A1/xx unknown
- 2002-10-29 CA CA2464471A patent/CA2464471C/en not_active Expired - Fee Related
- 2002-10-29 MX MXPA04004059A patent/MXPA04004059A/es unknown
-
2004
- 2004-06-01 NO NO20042257A patent/NO20042257L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658908A (en) * | 1992-02-03 | 1997-08-19 | Delta Pharmaceuticals, Inc. | Opioid diarylmethylpiperazines and piperdines |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2464471A1 (en) | 2003-05-08 |
| US20030144299A1 (en) | 2003-07-31 |
| NO20042257L (no) | 2004-06-24 |
| JP4892654B2 (ja) | 2012-03-07 |
| EP1450807A1 (en) | 2004-09-01 |
| EP1450807A4 (en) | 2008-06-25 |
| PL371297A1 (en) | 2005-06-13 |
| WO2003037342A1 (en) | 2003-05-08 |
| CA2464471C (en) | 2012-05-15 |
| RU2004115748A (ru) | 2005-03-27 |
| JP2005508363A (ja) | 2005-03-31 |
| EP1450807B1 (en) | 2013-12-25 |
| CN1596113A (zh) | 2005-03-16 |
| US7030124B2 (en) | 2006-04-18 |
| RU2314809C2 (ru) | 2008-01-20 |
| MXPA04004059A (es) | 2005-03-31 |
| TW200300089A (en) | 2003-05-16 |
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