RU2314809C2 - Способ лечения депрессии соединениями-агонистами дельта-рецепторов - Google Patents

Способ лечения депрессии соединениями-агонистами дельта-рецепторов Download PDF

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Publication number
RU2314809C2
RU2314809C2 RU2004115748/14A RU2004115748A RU2314809C2 RU 2314809 C2 RU2314809 C2 RU 2314809C2 RU 2004115748/14 A RU2004115748/14 A RU 2004115748/14A RU 2004115748 A RU2004115748 A RU 2004115748A RU 2314809 C2 RU2314809 C2 RU 2314809C2
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Russia
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composition
group
combating
depressive disorder
disorder
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RU2004115748/14A
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English (en)
Russian (ru)
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RU2004115748A (ru
Inventor
Квен-Джен ЧАНГ
Уильям ПЕНДЕРГАСТ
Дж. Питер ДЖЕНГО
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Маунт Кук Байосайенсиз, Инк.
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Publication of RU2004115748A publication Critical patent/RU2004115748A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2004115748/14A 2001-10-29 2002-10-29 Способ лечения депрессии соединениями-агонистами дельта-рецепторов RU2314809C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34008401P 2001-10-29 2001-10-29
US60/340,084 2001-10-29
US33788701P 2001-11-02 2001-11-02
US60/337,887 2001-11-02

Publications (2)

Publication Number Publication Date
RU2004115748A RU2004115748A (ru) 2005-03-27
RU2314809C2 true RU2314809C2 (ru) 2008-01-20

Family

ID=26990913

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004115748/14A RU2314809C2 (ru) 2001-10-29 2002-10-29 Способ лечения депрессии соединениями-агонистами дельта-рецепторов

Country Status (11)

Country Link
US (1) US7030124B2 (enExample)
EP (1) EP1450807B1 (enExample)
JP (1) JP4892654B2 (enExample)
CN (1) CN1596113B (enExample)
CA (1) CA2464471C (enExample)
MX (1) MXPA04004059A (enExample)
NO (1) NO20042257L (enExample)
PL (1) PL371297A1 (enExample)
RU (1) RU2314809C2 (enExample)
TW (1) TW200300089A (enExample)
WO (1) WO2003037342A1 (enExample)

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DE60230869D1 (de) * 2001-05-18 2009-03-05 Astrazeneca Ab 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203300D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) * 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
BRPI0415165A (pt) 2003-10-01 2007-01-09 Adolor Corp composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem
HRP20120343T1 (hr) * 2004-08-02 2012-05-31 Astrazeneca Ab Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP1874315A2 (en) * 2005-04-14 2008-01-09 Mount Cook Biosciences, Inc. Compositions of novel opioid compounds and method of use thereof
WO2007027987A2 (en) 2005-09-02 2007-03-08 Mount Cook Biosciences, Inc. Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2011520956A (ja) * 2008-05-20 2011-07-21 アストラゼネカ・アクチエボラーグ 不安大うつ病性障害を処置する方法
CN103467460A (zh) * 2013-09-23 2013-12-25 昆明理工大学 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用
CN105646151B (zh) * 2016-02-26 2018-06-29 山西大学 一种炔类化合物及其制备方法和该化合物的用途
US10973815B2 (en) 2016-03-31 2021-04-13 Versi Group, Llc Delta opioid agonist mu opioid antagonist compositions and methods for treating Parkinsons disease

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
RU2133744C1 (ru) * 1993-07-30 1999-07-27 Дельта Фармасьютикалз, Инк. Пиперазиновые соединения
JP2000026385A (ja) * 1998-04-16 2000-01-25 Pfizer Prod Inc Ｎ―アシル及びｎ―アロイルアラルキルアミド

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US20020052007A1 (en) 1992-02-03 2002-05-02 Chang Kwen Jen Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US6046200A (en) * 1994-09-09 2000-04-04 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
GB0017256D0 (en) * 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
DE60230869D1 (de) 2001-05-18 2009-03-05 Astrazeneca Ab 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
RU2133744C1 (ru) * 1993-07-30 1999-07-27 Дельта Фармасьютикалз, Инк. Пиперазиновые соединения
JP2000026385A (ja) * 1998-04-16 2000-01-25 Pfizer Prod Inc Ｎ―アシル及びｎ―アロイルアラルキルアミド

Non-Patent Citations (1)

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Title
Каплан Г.И. и др. Клиническая психиатрия в 2 тт., пер. с англ. - М.: Медицина, 1994, т.1, с.63-64, 315-330, 339-342 - расстройства настроения. Plobeck N. et al. New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased in vitro metabolic stability // J. Med. Chem. 2000 Oct 19; 43(21): 3878-94. Fumess М. Scott et al. Probes for narcotic receptor-mediated phenomena/ Synthesis and pharmacological evaluation of selective δ-opioid receptor agonists from 4-[(αR)-α-(2S,5R)-4-substituted-2,5-dimethyl-1-piperazmyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers // Journal of Medicinal chemistry, 2000, 43(16):3193-3196. *

Also Published As

Publication number Publication date
CA2464471A1 (en) 2003-05-08
US20030144299A1 (en) 2003-07-31
NO20042257L (no) 2004-06-24
JP4892654B2 (ja) 2012-03-07
CN1596113B (zh) 2010-05-26
EP1450807A1 (en) 2004-09-01
EP1450807A4 (en) 2008-06-25
PL371297A1 (en) 2005-06-13
WO2003037342A1 (en) 2003-05-08
CA2464471C (en) 2012-05-15
RU2004115748A (ru) 2005-03-27
JP2005508363A (ja) 2005-03-31
EP1450807B1 (en) 2013-12-25
CN1596113A (zh) 2005-03-16
US7030124B2 (en) 2006-04-18
MXPA04004059A (es) 2005-03-31
TW200300089A (en) 2003-05-16

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Effective date: 20101030