JP4891532B2 - 液体を取り扱うための装置ならびにその製造方法および使用 - Google Patents
液体を取り扱うための装置ならびにその製造方法および使用 Download PDFInfo
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- JP4891532B2 JP4891532B2 JP2004176152A JP2004176152A JP4891532B2 JP 4891532 B2 JP4891532 B2 JP 4891532B2 JP 2004176152 A JP2004176152 A JP 2004176152A JP 2004176152 A JP2004176152 A JP 2004176152A JP 4891532 B2 JP4891532 B2 JP 4891532B2
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/0896—Nanoscaled
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10326607A DE10326607A1 (de) | 2003-06-13 | 2003-06-13 | Vorrichtung zum Handhaben von Flüssigkeiten |
| DE10326607.0 | 2003-06-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005003688A JP2005003688A (ja) | 2005-01-06 |
| JP2005003688A5 JP2005003688A5 (enExample) | 2007-08-23 |
| JP4891532B2 true JP4891532B2 (ja) | 2012-03-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004176152A Expired - Lifetime JP4891532B2 (ja) | 2003-06-13 | 2004-06-14 | 液体を取り扱うための装置ならびにその製造方法および使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7931868B2 (enExample) |
| EP (1) | EP1495799A3 (enExample) |
| JP (1) | JP4891532B2 (enExample) |
| CN (1) | CN100500295C (enExample) |
| DE (1) | DE10326607A1 (enExample) |
Families Citing this family (51)
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| DE10326607A1 (de) * | 2003-06-13 | 2005-01-05 | Steag Microparts Gmbh | Vorrichtung zum Handhaben von Flüssigkeiten |
| DE102004007567A1 (de) * | 2004-02-17 | 2005-09-01 | Boehringer Ingelheim Microparts Gmbh | Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit |
| WO2006039568A1 (en) * | 2004-10-01 | 2006-04-13 | Velocys Inc. | Multiphase mixing process using microchannel process technology |
| WO2006061026A2 (en) * | 2004-12-09 | 2006-06-15 | Inverness Medical Switzerland Gmbh | A micro fluidic device and methods for producing a micro fluidic device |
| US20100089529A1 (en) * | 2005-01-12 | 2010-04-15 | Inverness Medical Switzerland Gmbh | Microfluidic devices and production methods therefor |
| DE502006009183D1 (de) * | 2005-01-27 | 2011-05-12 | Boehringer Ingelheim Micropart | Verwendung einer Vorrichtung zur Untersuchung von Probenflüssigkeit |
| CN101180540A (zh) * | 2005-03-29 | 2008-05-14 | 因弗因斯医药瑞士股份有限公司 | 混合器件 |
| AU2006236410B2 (en) * | 2005-04-19 | 2012-11-01 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
| US8288151B2 (en) * | 2005-06-29 | 2012-10-16 | Canon Kabushiki Kaisha | Biochemical reaction cassette |
| US7883665B2 (en) * | 2005-09-14 | 2011-02-08 | Alcatel-Lucent Usa Inc. | Chemical and biological detection arrays |
| EP1772722A1 (de) * | 2005-10-07 | 2007-04-11 | Micronas Holding GmbH | Reaktionskammer |
| JP2009515162A (ja) * | 2005-11-07 | 2009-04-09 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 支柱ベースバイオセンサー及びその作製方法 |
| DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
| JPWO2007066518A1 (ja) * | 2005-12-08 | 2009-05-14 | 日本電気株式会社 | 接液構造、液体の移動制御構造、および液体の移動制御方法 |
| WO2007122819A1 (ja) * | 2006-04-18 | 2007-11-01 | Ngk Insulators, Ltd. | 液体を媒体とする反応のための装置 |
| JPWO2007122785A1 (ja) * | 2006-04-18 | 2009-08-27 | 日本碍子株式会社 | 反応装置、該反応装置用反応モジュール及び該反応装置用送液装置 |
| US20070280857A1 (en) * | 2006-06-02 | 2007-12-06 | Applera Corporation | Devices and Methods for Positioning Dried Reagent In Microfluidic Devices |
| JP2010511147A (ja) * | 2006-11-23 | 2010-04-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 試料における分析物の分離及びmaldi分析のためのデバイス |
| JP5137551B2 (ja) * | 2006-12-28 | 2013-02-06 | キヤノン株式会社 | 生化学反応カセット |
| WO2008083687A1 (en) * | 2007-01-10 | 2008-07-17 | Scandinavian Micro Biodevices Aps | A microfluidic device and a microfluidic system and a method of performing a test |
| JP5004169B2 (ja) * | 2007-05-30 | 2012-08-22 | ローム株式会社 | マイクロチップの製造方法 |
| JP4861353B2 (ja) * | 2008-02-01 | 2012-01-25 | 日本電信電話株式会社 | フローセル |
| WO2009106331A2 (de) * | 2008-02-27 | 2009-09-03 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur plasmaseparation |
| SE533514C2 (sv) * | 2008-06-16 | 2010-10-12 | Aamic Ab | Analysanordning och förfarande |
| US8974749B2 (en) * | 2008-06-16 | 2015-03-10 | Johnson & Johnson Ab | Assay device and method |
| JP5242503B2 (ja) * | 2008-06-16 | 2013-07-24 | オーミック・アーベー | アッセイ装置および方法 |
| JP4852573B2 (ja) * | 2008-06-18 | 2012-01-11 | 日本電信電話株式会社 | フローセル |
| EP2187263A1 (en) * | 2008-11-13 | 2010-05-19 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | A method for forming a multi-level surface on a substrate with areas of different wettability and a semiconductor device having the same. |
| WO2011003689A2 (en) * | 2009-07-07 | 2011-01-13 | Boehringer Ingelheim Microparts Gmbh | Plasma separation reservoir |
| JP5618556B2 (ja) * | 2010-01-28 | 2014-11-05 | 株式会社日立ハイテクノロジーズ | 核酸分析装置,核酸分析反応デバイス、および核酸分析用反応デバイス用基板 |
| ES2401367T3 (es) * | 2010-02-12 | 2013-04-19 | Consejo Superior De Investigaciones Científicas | Método para producir un sello de polímero para la reproducción de dispositivos que comprenden microestructuras y nanoestructuras, y dispositivo correspondiente |
| KR100961874B1 (ko) * | 2010-04-05 | 2010-06-09 | 주식회사 나노엔텍 | 외부동력 없이 유체가 이동하는 유체분석용 칩 |
| JP5177915B2 (ja) * | 2011-04-25 | 2013-04-10 | 日本電信電話株式会社 | フローセル |
| US20130189672A1 (en) | 2012-01-20 | 2013-07-25 | Ortho-Clinical Diagnostics, Inc. | Assay Device Having Multiple Reagent Cells |
| PL398979A1 (pl) * | 2012-04-25 | 2013-10-28 | Scope Fluidics Spólka Z Ograniczona Odpowiedzialnoscia | Urzadzenie mikroprzeplywowe i uklad mikroprzeplywowy obejmujacy jedno lub wiecej urzadzen mikroprzeplywowych |
| GB201217390D0 (en) * | 2012-09-28 | 2012-11-14 | Agplus Diagnostics Ltd | Test device and sample carrier |
| JP6120440B2 (ja) * | 2013-04-30 | 2017-04-26 | 国立研究開発法人産業技術総合研究所 | マイクロチャンバー及び液体の混合方法 |
| JP5685630B2 (ja) * | 2013-07-19 | 2015-03-18 | Jfeエンジニアリング株式会社 | マイクロチップ |
| CN104209489B (zh) * | 2014-08-26 | 2016-06-08 | 中国科学院力学研究所 | 一种实现金属构件移动微压铸成型的装置 |
| JP6796371B2 (ja) | 2014-11-28 | 2020-12-09 | デクセリアルズ株式会社 | マイクロ流路作製用原盤の製造方法 |
| FR3056927B1 (fr) * | 2016-09-30 | 2021-07-09 | Ecole Polytech | Procede microfluidique de manipulation de microgouttes |
| JP2017024170A (ja) * | 2016-10-18 | 2017-02-02 | 大日本印刷株式会社 | マイクロ流路装置 |
| KR101993305B1 (ko) * | 2017-06-01 | 2019-06-26 | 주식회사 스몰머신즈 | 유체 분석용 마이크로 칩 |
| CN109663621A (zh) * | 2019-01-17 | 2019-04-23 | 京东方科技集团股份有限公司 | 一种微纳结构基板的制备方法、微纳流控芯片及器件 |
| US20220297126A1 (en) * | 2019-07-30 | 2022-09-22 | Texas Tech University System | Microfluidic Pipette Aspirators for Large-Scale Analysis of Single Cells, Clusters and Their Sub-Populations |
| DE102020210219A1 (de) | 2020-08-12 | 2022-02-17 | Robert Bosch Gesellschaft mit beschränkter Haftung | Flusszelle zum Integrieren einer Prozessierungseinheit in eine mikrofluidische Vorrichtung und Verfahren zum Prozessieren einer Probenflüssigkeit |
| CN112666050B (zh) * | 2020-11-30 | 2023-06-02 | 江苏科技大学 | 一种功能表面亲水性能测试装置及表征方法 |
| CN113797986B (zh) * | 2021-10-11 | 2023-05-26 | 苏州美翎生物医学科技有限公司 | 一种可微调毛细管同轴排列的微流控芯片 |
| JP2024029792A (ja) * | 2022-08-23 | 2024-03-07 | 東洋製罐グループホールディングス株式会社 | マイクロ流体デバイス、検査システム、及び検査方法 |
| DE102022209417A1 (de) * | 2022-09-09 | 2024-03-14 | Robert Bosch Gesellschaft mit beschränkter Haftung | Array für eine mikrofluidische Vorrichtung, mikrofluidische Vorrichtung und Verfahren zu ihrem Betrieb |
| DE102024114091A1 (de) * | 2024-05-21 | 2025-11-27 | pluriSelect Life Science UG (haftungsbeschränkt) & Co. KG | Schicht mit mikrostrukturierter Oberfläche |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271119A (en) * | 1979-07-23 | 1981-06-02 | Eastman Kodak Company | Capillary transport device having connected transport zones |
| JPH03223674A (ja) | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | 反応容器 |
| AU642444B2 (en) * | 1989-11-30 | 1993-10-21 | Mochida Pharmaceutical Co., Ltd. | Reaction vessel |
| US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5707799A (en) * | 1994-09-30 | 1998-01-13 | Abbott Laboratories | Devices and methods utilizing arrays of structures for analyte capture |
| US6368871B1 (en) * | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
| CN100435900C (zh) * | 1998-09-17 | 2008-11-26 | 阿德文生物科学公司 | 液相色谱系统,化学分离装置及质谱分析装置和方法 |
| US6601613B2 (en) * | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
| DE19859693A1 (de) * | 1998-12-23 | 2000-06-29 | Microparts Gmbh | Vorrichtung zum Ableiten einer Flüssigkeit aus Kapillaren |
| US6664104B2 (en) * | 1999-06-25 | 2003-12-16 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
| US6451264B1 (en) * | 2000-01-28 | 2002-09-17 | Roche Diagnostics Corporation | Fluid flow control in curved capillary channels |
| CN1109757C (zh) * | 2000-10-10 | 2003-05-28 | 陆祖宏 | 化合物微通道阵列芯片及其制备方法 |
| DE10110589A1 (de) * | 2001-03-06 | 2002-09-12 | Creavis Tech & Innovation Gmbh | Geometrische Formgebung von Oberflächen mit Lotus-Effekt |
| DE10120035B4 (de) * | 2001-04-24 | 2005-07-07 | Advalytix Ag | Verfahren und Vorrichtung zur Manipulation kleiner Flüssigkeitsmengen auf Oberflächen |
| GB0116384D0 (en) * | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| DE10134362A1 (de) * | 2001-07-14 | 2003-01-30 | Creavis Tech & Innovation Gmbh | Strukturierte Oberflächen mit Lotus-Effekt |
| WO2003046508A2 (en) * | 2001-11-09 | 2003-06-05 | Biomicroarrays, Inc. | High surface area substrates for microarrays and methods to make same |
| DE10326607A1 (de) * | 2003-06-13 | 2005-01-05 | Steag Microparts Gmbh | Vorrichtung zum Handhaben von Flüssigkeiten |
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|---|---|
| US20110172109A1 (en) | 2011-07-14 |
| EP1495799A2 (de) | 2005-01-12 |
| CN1597119A (zh) | 2005-03-23 |
| CN100500295C (zh) | 2009-06-17 |
| DE10326607A1 (de) | 2005-01-05 |
| JP2005003688A (ja) | 2005-01-06 |
| EP1495799A3 (de) | 2007-04-04 |
| US20050026346A1 (en) | 2005-02-03 |
| US7931868B2 (en) | 2011-04-26 |
| US8318110B2 (en) | 2012-11-27 |
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