JP4889502B2 - ヘテロアリール置換ベンゼン - Google Patents

ヘテロアリール置換ベンゼン Download PDF

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Publication number
JP4889502B2
JP4889502B2 JP2006543421A JP2006543421A JP4889502B2 JP 4889502 B2 JP4889502 B2 JP 4889502B2 JP 2006543421 A JP2006543421 A JP 2006543421A JP 2006543421 A JP2006543421 A JP 2006543421A JP 4889502 B2 JP4889502 B2 JP 4889502B2
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JP
Japan
Prior art keywords
amino
phenyl
mmol
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2006543421A
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English (en)
Japanese (ja)
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JP2007513901A5 (https=
JP2007513901A (ja
Inventor
サミール・ベナビ
ハイケ・ヘックロート
ハルトムート・シロック
ヨアヒム・ミッテンドルフ
ライムント・カスト
ヨハネス−ペーター・シュタッシュ
マルク・ジャン・グノート
クラウス・ミュンター
ディーター・ラング
サンティアゴ・フィゲロア・ペレス
マルクス・バウザー
アヒム・フォイラー
ハイモ・エームケ
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Bayer Pharma AG
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Bayer Pharma AG
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Publication of JP2007513901A publication Critical patent/JP2007513901A/ja
Publication of JP2007513901A5 publication Critical patent/JP2007513901A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006543421A 2003-12-09 2004-11-26 ヘテロアリール置換ベンゼン Expired - Fee Related JP4889502B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10357510A DE10357510A1 (de) 2003-12-09 2003-12-09 Heteroarylsubstituierte Benzole
DE10357510.3 2003-12-09
PCT/EP2004/013430 WO2005058891A1 (de) 2003-12-09 2004-11-26 Pyrrolopyridin-substituierte benzol-derivate zur behandlung kardiovaskulärer erkrankungen

Publications (3)

Publication Number Publication Date
JP2007513901A JP2007513901A (ja) 2007-05-31
JP2007513901A5 JP2007513901A5 (https=) 2008-01-17
JP4889502B2 true JP4889502B2 (ja) 2012-03-07

Family

ID=34638534

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006543421A Expired - Fee Related JP4889502B2 (ja) 2003-12-09 2004-11-26 ヘテロアリール置換ベンゼン

Country Status (7)

Country Link
US (1) US20080249105A1 (https=)
EP (1) EP1709043B1 (https=)
JP (1) JP4889502B2 (https=)
CA (1) CA2550128C (https=)
DE (2) DE10357510A1 (https=)
ES (1) ES2317073T3 (https=)
WO (1) WO2005058891A1 (https=)

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US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
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US8530444B2 (en) * 2010-06-01 2013-09-10 Aposense Ltd. Pharmaceutical compounds
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TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
CA2856291C (en) 2011-11-17 2020-08-11 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
CN102603740B (zh) * 2012-03-01 2014-05-14 南京药石药物研发有限公司 4-硝基-7-氮杂吲哚的合成方法
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EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
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Also Published As

Publication number Publication date
CA2550128C (en) 2012-09-11
DE502004008604D1 (de) 2009-01-15
DE10357510A1 (de) 2005-07-07
US20080249105A1 (en) 2008-10-09
EP1709043B1 (de) 2008-12-03
JP2007513901A (ja) 2007-05-31
EP1709043A1 (de) 2006-10-11
ES2317073T3 (es) 2009-04-16
CA2550128A1 (en) 2005-06-30
WO2005058891A1 (de) 2005-06-30

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