JP4887297B2 - 新規二環式抗生物質 - Google Patents

新規二環式抗生物質 Download PDF

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Publication number
JP4887297B2
JP4887297B2 JP2007532823A JP2007532823A JP4887297B2 JP 4887297 B2 JP4887297 B2 JP 4887297B2 JP 2007532823 A JP2007532823 A JP 2007532823A JP 2007532823 A JP2007532823 A JP 2007532823A JP 4887297 B2 JP4887297 B2 JP 4887297B2
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JP
Japan
Prior art keywords
methoxy
pyran
tetrahydro
methyl
pyrido
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Expired - Fee Related
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JP2007532823A
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English (en)
Japanese (ja)
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JP2008514563A (ja
JP2008514563A5 (fr
Inventor
ヒューブシェヴェーレン クリスチャン
サリーヴェット ジーン−フィリッペ
ザンブルーン−アクリン コルネリア
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP2007532823A 2004-09-24 2005-09-20 新規二環式抗生物質 Expired - Fee Related JP4887297B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP2004010762 2004-09-24
EPPCT/EP2004/010762 2004-09-24
EP2005007731 2005-07-15
EPPCT/EP2005/007731 2005-07-15
PCT/EP2005/010154 WO2006032466A2 (fr) 2004-09-24 2005-09-20 Nouveaux antibiotiques bicycliques

Publications (3)

Publication Number Publication Date
JP2008514563A JP2008514563A (ja) 2008-05-08
JP2008514563A5 JP2008514563A5 (fr) 2011-12-08
JP4887297B2 true JP4887297B2 (ja) 2012-02-29

Family

ID=36090370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007532823A Expired - Fee Related JP4887297B2 (ja) 2004-09-24 2005-09-20 新規二環式抗生物質

Country Status (5)

Country Link
JP (1) JP4887297B2 (fr)
AR (1) AR050958A1 (fr)
CA (1) CA2580621A1 (fr)
TW (1) TW200615267A (fr)
WO (1) WO2006032466A2 (fr)

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US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
JP2008542249A (ja) * 2005-05-24 2008-11-27 アストラゼネカ アクチボラグ 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
ES2376488T3 (es) 2006-01-26 2012-03-14 Actelion Pharmaceuticals Ltd. Antibióticos de tetrahidropirano.
CN101384604B (zh) 2006-02-15 2012-08-08 埃科特莱茵药品有限公司 乙醇或乙二醇环己基抗菌素衍生物
CA2643962A1 (fr) * 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Composes antibiotiques
ATE481406T1 (de) 2006-04-06 2010-10-15 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
CN101448824A (zh) * 2006-06-08 2009-06-03 斯皮德尔实验股份公司 2,5-双基取代的哌啶
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
TW200819457A (en) 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
CL2007003693A1 (es) * 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
DK2137196T3 (da) 2007-04-20 2011-01-10 Glaxo Group Ltd Tricykliske nitrogenholdige forbindelser som antibakterielle midler
BRPI0812942B1 (pt) * 2007-06-15 2018-11-21 Actelion Pharmaceuticals Ltd composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto.
EP2005995A1 (fr) * 2007-06-22 2008-12-24 Glaxo Group Limited Composés hétérocycliques pour le traitement de la tuberculose
WO2009077989A1 (fr) 2007-12-18 2009-06-25 Actelion Pharmaceuticals Ltd Dérivés 5-aminocyclylméthyloxazolidin-2-one
EP2080761A1 (fr) 2008-01-18 2009-07-22 Glaxo Group Limited Composés
JP5349500B2 (ja) 2008-02-20 2013-11-20 アクテリオン ファーマシューティカルズ リミテッド アザトリシクリック抗菌性化合物
JP2011518149A (ja) 2008-04-15 2011-06-23 アクテリオン ファーマシューティカルズ リミテッド 三環式抗菌剤
CN102046603B (zh) 2008-06-03 2014-08-13 埃科特莱茵药品有限公司 作为抗细菌剂的[4-(1-氨基-乙基)-环己基]-甲基-胺及[6-(1-氨基-乙基)-四氢-吡喃-3-基]-甲基-胺衍生物
WO2010015985A1 (fr) 2008-08-04 2010-02-11 Actelion Pharmaceuticals Ltd Dérivés d'alkylaminométhyloxazolidinone tricycliques
CN104151316B (zh) 2008-10-07 2016-06-15 埃科特莱茵药品有限公司 三环噁唑烷酮抗生素化合物
WO2010043714A1 (fr) 2008-10-17 2010-04-22 Glaxo Group Limited Composés azotés tricycliques utilisés comme agents antibactériens
CA2740863A1 (fr) 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Acides naphtylacetiques
NZ593891A (en) 2008-12-12 2013-05-31 Actelion Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
EP2379554B1 (fr) 2009-01-15 2015-11-11 Glaxo Group Limited Composés naphthyridine-2(1h)-one utiles comme antibactériens
CA2750047A1 (fr) 2009-01-21 2010-07-29 Basilea Pharmaceutica Ag Nouveaux antibiotiques bicycliques
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
SG10201601802YA (en) 2011-03-10 2016-04-28 Daiichi Sankyo Co Ltd Dispiropyrrolidine derivatives
EP2685828A4 (fr) * 2011-03-17 2014-08-13 Merck Sharp & Dohme Dérivés de 3-azabicyclo[3.1.0]hexane substitués utiles en tant qu'antagonistes de ccr2
AU2012270051B2 (en) * 2011-06-17 2016-12-22 Pfizer Anti-Infectives Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
US20140243302A1 (en) * 2011-06-27 2014-08-28 Merck Sharp & Dohme Corporation Bridged bicyclic compounds for the treatment of bacterial infections
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
CN103958525A (zh) 2011-11-30 2014-07-30 埃科特莱茵药品有限公司 3,7-二取代八氢-2H-吡啶并[4,3-e][1,3]噁嗪-2-酮抗生素
MX2017002321A (es) 2014-08-22 2017-08-02 Glaxosmithkline Ip Dev Ltd Compuestos que contienen nitrogeno triciclico para tratar infeccion por neisseria gonorrhoeae.
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
CN111201245B (zh) * 2017-09-01 2024-04-05 戴纳立制药公司 化合物、组合物和方法
MX2020002944A (es) 2017-09-14 2020-09-28 Daiichi Sankyo Co Ltd Compuesto que tiene estructura ciclica.
CN109082280B (zh) * 2018-11-05 2020-07-28 宁夏中星显示材料有限公司 一种液晶材料的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003064421A1 (fr) * 2002-01-29 2003-08-07 Glaxo Group Limited Derives aminopiperidine
WO2004002992A1 (fr) * 2002-06-26 2004-01-08 Glaxo Group Limited Composés
WO2004002490A2 (fr) * 2002-06-26 2004-01-08 Glaxo Group Limited Composes
WO2004035569A2 (fr) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Nouveaux composes antibacteriens
DE10256405A1 (de) * 2002-12-02 2004-06-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
WO2004089942A2 (fr) * 2001-10-02 2004-10-21 Acadia Pharmaceuticals Inc. Derives de benzimidazolidinone utilises en tant qu'agents muscariniques
WO2006012396A1 (fr) * 2004-07-22 2006-02-02 Glaxo Group Limited Agents antibacteriens
WO2006021448A1 (fr) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Nouveaux composes presentant une activite antibacterienne

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089942A2 (fr) * 2001-10-02 2004-10-21 Acadia Pharmaceuticals Inc. Derives de benzimidazolidinone utilises en tant qu'agents muscariniques
WO2003064421A1 (fr) * 2002-01-29 2003-08-07 Glaxo Group Limited Derives aminopiperidine
WO2004002992A1 (fr) * 2002-06-26 2004-01-08 Glaxo Group Limited Composés
WO2004002490A2 (fr) * 2002-06-26 2004-01-08 Glaxo Group Limited Composes
WO2004035569A2 (fr) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Nouveaux composes antibacteriens
DE10256405A1 (de) * 2002-12-02 2004-06-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
WO2006012396A1 (fr) * 2004-07-22 2006-02-02 Glaxo Group Limited Agents antibacteriens
WO2006021448A1 (fr) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Nouveaux composes presentant une activite antibacterienne

Also Published As

Publication number Publication date
JP2008514563A (ja) 2008-05-08
WO2006032466A2 (fr) 2006-03-30
AR050958A1 (es) 2006-12-06
WO2006032466A3 (fr) 2006-12-14
CA2580621A1 (fr) 2006-03-30
TW200615267A (en) 2006-05-16

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