JP4884974B2 - 粘膜炎の予防及び処置のためのメチオニンの治療上の使用 - Google Patents
粘膜炎の予防及び処置のためのメチオニンの治療上の使用 Download PDFInfo
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- JP4884974B2 JP4884974B2 JP2006538213A JP2006538213A JP4884974B2 JP 4884974 B2 JP4884974 B2 JP 4884974B2 JP 2006538213 A JP2006538213 A JP 2006538213A JP 2006538213 A JP2006538213 A JP 2006538213A JP 4884974 B2 JP4884974 B2 JP 4884974B2
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| US10/694,436 US20050090551A1 (en) | 2003-10-27 | 2003-10-27 | Therapeutic use of methionine for the treatment or prevention of mucositis |
| US10/694,436 | 2003-10-27 | ||
| PCT/US2004/035626 WO2005039554A2 (en) | 2003-10-27 | 2004-10-27 | Therapeutic use of methionine for the treatment or prevention of mucositis |
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| JP2007509955A JP2007509955A (ja) | 2007-04-19 |
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| US7071230B2 (en) * | 1997-10-02 | 2006-07-04 | Board Of Trustees Of Southern Illinois University | Therapeutic use of D-methionine to reduce the toxicity of noise |
| CN101453985A (zh) * | 2006-03-28 | 2009-06-10 | 诺华丝国际股份有限公司 | 促进毛发生长的组合物 |
| GB0704718D0 (en) * | 2007-03-12 | 2007-04-18 | Prendergast Patrick T | Compounds and methods for preventing and treating mucositis |
| KR20200075044A (ko) | 2008-01-22 | 2020-06-25 | 아라임 파마슈티칼즈, 인크. | 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
| JP2011514349A (ja) | 2008-03-07 | 2011-05-06 | サイドース・エルエルシー | フルベストラント配合物 |
| EP2478899B1 (en) * | 2009-09-14 | 2018-05-09 | Shiseido Company, Ltd. | Composition for alleviating ultraviolet irradiation-induced damage |
| EP2484353A4 (en) * | 2009-09-30 | 2013-04-17 | Shiseido Co Ltd | ORAL ACCEPTABLE COMPOSITION FOR TREATMENT BY ULTRAVIOLETTREADING OF INDIRECT DAMAGES |
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| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
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| US11179468B2 (en) | 2012-04-09 | 2021-11-23 | Eagle Pharmaceuticals, Inc. | Fulvestrant formulations |
| WO2020036975A1 (en) * | 2018-08-14 | 2020-02-20 | Tosk, Inc. | Methods and compositions for reducing fluorouracil induced toxicity |
| US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| EP4178581A4 (en) | 2020-07-07 | 2024-06-05 | Tosk, Inc. | URIDINE PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF LUNG DISEASES |
| CN114051974B (zh) * | 2021-11-10 | 2023-01-17 | 广西医科大学 | 一种肝癌模型及其构建方法与应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518499A (ja) * | 1997-10-02 | 2001-10-16 | サザン・イリノイ・ユニバーシティ | 耳毒性薬、騒音および放射線の毒性を軽減するためのｄ−メチオニンの使用 |
| JP2002502881A (ja) * | 1998-02-13 | 2002-01-29 | ニュートラマックス ラボラトリーズ，インコーポレイテッド | 結合組織を保護、治療、および修復するための薬剤および方法 |
| WO2002041837A2 (en) * | 2000-11-22 | 2002-05-30 | Rxkinetix, Inc. | Treatment of mucositis |
| WO2002071874A2 (en) * | 2001-03-09 | 2002-09-19 | Societe Des Produits Nestle S.A. | Composition improving age-related physiological deficits and increasing longevity |
| JP2003504345A (ja) * | 1999-07-13 | 2003-02-04 | ビオヴィトルム・アクチボラゲット | 安定第ｖｉｉｉ因子組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652290A (en) * | 1970-08-10 | 1972-03-28 | Merck & Co Inc | Beverages containing stabilized vitamin c |
| US3962429A (en) * | 1973-08-01 | 1976-06-08 | Chugai Seiyaku Kabushiki Kaisha | Method for reducing side effects of aminoglycoside antibiotics and composition therefor |
| US4961926A (en) * | 1987-11-19 | 1990-10-09 | Sloan-Kettering Institute For Cancer Research | Methods for prevention and treatment of mucositis with granulocyte colony stimulating factor |
| US5122369A (en) * | 1990-03-30 | 1992-06-16 | Harmony Health Products, Inc. | Nutrient composition for preventing hair loss |
| MX9700053A (es) * | 1994-07-01 | 1997-04-30 | Procter & Gamble | Composiciones de descamacion. |
| JPH08190187A (ja) * | 1995-01-11 | 1996-07-23 | Canon Inc | 情報記録装置 |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| WO1998014182A1 (en) * | 1996-10-03 | 1998-04-09 | Southern Illinois University | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
| ES2282326T3 (es) * | 2000-10-24 | 2007-10-16 | Cis Bio International | Estabilizacion de composiciones radio-farmaceuticas usando tioeteres hidrofilicos o 6-hidroxicromanos hidrofilicos. |
| EP1461033B1 (en) * | 2001-11-29 | 2013-02-27 | Sound Pharmaceuticals Incorporated | Methods and compositions for ameliorating the undesirable effects of chemotherapy |
| US20040198841A1 (en) * | 2003-03-13 | 2004-10-07 | Oregon Health & Science University | Use of thiol-based compositions in ameliorating mucosal injury |
| US20060058390A1 (en) * | 2004-09-14 | 2006-03-16 | Molecular Therapeutics, Inc. | D-methionine formulation with improved biopharmaceutical properties |
-
2003
- 2003-10-27 US US10/694,436 patent/US20050090551A1/en not_active Abandoned
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2004
- 2004-10-27 AT AT04810055T patent/ATE536178T1/de active
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- 2004-10-27 JP JP2006538213A patent/JP4884974B2/ja not_active Expired - Fee Related
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518499A (ja) * | 1997-10-02 | 2001-10-16 | サザン・イリノイ・ユニバーシティ | 耳毒性薬、騒音および放射線の毒性を軽減するためのｄ−メチオニンの使用 |
| JP2002502881A (ja) * | 1998-02-13 | 2002-01-29 | ニュートラマックス ラボラトリーズ，インコーポレイテッド | 結合組織を保護、治療、および修復するための薬剤および方法 |
| JP2003504345A (ja) * | 1999-07-13 | 2003-02-04 | ビオヴィトルム・アクチボラゲット | 安定第ｖｉｉｉ因子組成物 |
| WO2002041837A2 (en) * | 2000-11-22 | 2002-05-30 | Rxkinetix, Inc. | Treatment of mucositis |
| WO2002071874A2 (en) * | 2001-03-09 | 2002-09-19 | Societe Des Produits Nestle S.A. | Composition improving age-related physiological deficits and increasing longevity |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050090551A1 (en) | 2005-04-28 |
| JP2007509955A (ja) | 2007-04-19 |
| AU2004283756B2 (en) | 2010-07-29 |
| AU2004283756A1 (en) | 2005-05-06 |
| WO2005039554A2 (en) | 2005-05-06 |
| WO2005039554A3 (en) | 2005-12-15 |
| AU2004283756A2 (en) | 2005-05-06 |
| ATE536178T1 (de) | 2011-12-15 |
| ES2376102T3 (es) | 2012-03-09 |
| CA2543870A1 (en) | 2005-05-06 |
| EP1677775A2 (en) | 2006-07-12 |
| CA2543870C (en) | 2013-03-12 |
| EP1677775B1 (en) | 2011-12-07 |
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