CA2543870C - Therapeutic use of methionine for the treatment or prevention of mucositis - Google Patents
Therapeutic use of methionine for the treatment or prevention of mucositis Download PDFInfo
- Publication number
- CA2543870C CA2543870C CA2543870A CA2543870A CA2543870C CA 2543870 C CA2543870 C CA 2543870C CA 2543870 A CA2543870 A CA 2543870A CA 2543870 A CA2543870 A CA 2543870A CA 2543870 C CA2543870 C CA 2543870C
- Authority
- CA
- Canada
- Prior art keywords
- methionine
- platinum
- protective agent
- administration
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title claims abstract description 66
- 229930182817 methionine Natural products 0.000 title claims abstract description 52
- 206010028116 Mucosal inflammation Diseases 0.000 title claims abstract description 45
- 201000010927 Mucositis Diseases 0.000 title claims abstract description 45
- 238000011282 treatment Methods 0.000 title claims abstract description 37
- 230000002265 prevention Effects 0.000 title claims description 10
- 230000001225 therapeutic effect Effects 0.000 title description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 133
- 239000003223 protective agent Substances 0.000 claims abstract description 127
- 150000001875 compounds Chemical class 0.000 claims abstract description 76
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 67
- 230000005855 radiation Effects 0.000 claims abstract description 50
- 230000000259 anti-tumor effect Effects 0.000 claims abstract description 41
- 229930182818 D-methionine Natural products 0.000 claims description 92
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims description 91
- 229960004452 methionine Drugs 0.000 claims description 69
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- 239000002246 antineoplastic agent Substances 0.000 claims description 53
- 125000004432 carbon atom Chemical group C* 0.000 claims description 32
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical group N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 31
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims description 23
- 125000002252 acyl group Chemical group 0.000 claims description 20
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- -1 ifosamide Chemical compound 0.000 claims description 20
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- 230000000973 chemotherapeutic effect Effects 0.000 claims description 16
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 claims description 16
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- 150000003839 salts Chemical class 0.000 claims description 15
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 8
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 8
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- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 7
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- MIQJGZAEWQQAPN-YFKPBYRVSA-N (2s)-2-amino-4-methylsulfanylbutan-1-ol Chemical compound CSCC[C@H](N)CO MIQJGZAEWQQAPN-YFKPBYRVSA-N 0.000 claims description 5
- GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 claims description 5
- SFSJZXMDTNDWIX-YFKPBYRVSA-N L-homomethionine Chemical compound CSCCC[C@H](N)C(O)=O SFSJZXMDTNDWIX-YFKPBYRVSA-N 0.000 claims description 5
- SFSJZXMDTNDWIX-UHFFFAOYSA-N homomethionine Natural products CSCCCC(N)C(O)=O SFSJZXMDTNDWIX-UHFFFAOYSA-N 0.000 claims description 5
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- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 4
- VWCPNTATQBOMGQ-UHFFFAOYSA-M bis(2-azanidylethyl)azanide;platinum(4+);chloride Chemical compound [Cl-].[Pt+4].[NH-]CC[N-]CC[NH-] VWCPNTATQBOMGQ-UHFFFAOYSA-M 0.000 claims description 4
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Dermatology (AREA)
- Biochemistry (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/694,436 | 2003-10-27 | ||
| US10/694,436 US20050090551A1 (en) | 2003-10-27 | 2003-10-27 | Therapeutic use of methionine for the treatment or prevention of mucositis |
| PCT/US2004/035626 WO2005039554A2 (en) | 2003-10-27 | 2004-10-27 | Therapeutic use of methionine for the treatment or prevention of mucositis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2543870A1 CA2543870A1 (en) | 2005-05-06 |
| CA2543870C true CA2543870C (en) | 2013-03-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2543870A Expired - Fee Related CA2543870C (en) | 2003-10-27 | 2004-10-27 | Therapeutic use of methionine for the treatment or prevention of mucositis |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050090551A1 (https=) |
| EP (1) | EP1677775B1 (https=) |
| JP (1) | JP4884974B2 (https=) |
| AT (1) | ATE536178T1 (https=) |
| AU (1) | AU2004283756B2 (https=) |
| CA (1) | CA2543870C (https=) |
| ES (1) | ES2376102T3 (https=) |
| WO (1) | WO2005039554A2 (https=) |
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| US7071230B2 (en) * | 1997-10-02 | 2006-07-04 | Board Of Trustees Of Southern Illinois University | Therapeutic use of D-methionine to reduce the toxicity of noise |
| US20070231377A1 (en) * | 2006-03-28 | 2007-10-04 | Novus International Inc. | Compositions for promoting hair growth |
| GB0704718D0 (en) * | 2007-03-12 | 2007-04-18 | Prendergast Patrick T | Compounds and methods for preventing and treating mucositis |
| WO2009094172A2 (en) | 2008-01-22 | 2009-07-30 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| JP2011514349A (ja) | 2008-03-07 | 2011-05-06 | サイドース・エルエルシー | フルベストラント配合物 |
| KR20120041740A (ko) * | 2009-09-14 | 2012-05-02 | 가부시키가이샤 시세이도 | 자외선 장해 경감 조성물 |
| CN102481277A (zh) * | 2009-09-30 | 2012-05-30 | 株式会社资生堂 | 紫外线损伤减轻口服组合物 |
| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
| US8541465B2 (en) | 2009-10-19 | 2013-09-24 | Scidose, Llc | Docetaxel formulations with lipoic acid and/or dihydrolipoic acid |
| US8476310B2 (en) | 2009-10-19 | 2013-07-02 | Scidose Llc | Docetaxel formulations with lipoic acid |
| US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
| JP5578997B2 (ja) * | 2010-09-16 | 2014-08-27 | 国立大学法人 大分大学 | がん化学療法誘発脱毛に対する抗脱毛用組成物 |
| US11179468B2 (en) | 2012-04-09 | 2021-11-23 | Eagle Pharmaceuticals, Inc. | Fulvestrant formulations |
| CN112839663A (zh) * | 2018-08-14 | 2021-05-25 | 托斯克公司 | 降低氟尿嘧啶诱发的毒性的方法和组合物 |
| US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| WO2022010778A1 (en) | 2020-07-07 | 2022-01-13 | Tosk, Inc. | Uridine phosphorylase inhibitors to treat or prevent pulmonary disease |
| CN114051974B (zh) * | 2021-11-10 | 2023-01-17 | 广西医科大学 | 一种肝癌模型及其构建方法与应用 |
Family Cites Families (17)
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| US3652290A (en) * | 1970-08-10 | 1972-03-28 | Merck & Co Inc | Beverages containing stabilized vitamin c |
| US3962429A (en) * | 1973-08-01 | 1976-06-08 | Chugai Seiyaku Kabushiki Kaisha | Method for reducing side effects of aminoglycoside antibiotics and composition therefor |
| US4961926A (en) * | 1987-11-19 | 1990-10-09 | Sloan-Kettering Institute For Cancer Research | Methods for prevention and treatment of mucositis with granulocyte colony stimulating factor |
| US5122369A (en) * | 1990-03-30 | 1992-06-16 | Harmony Health Products, Inc. | Nutrient composition for preventing hair loss |
| AU703079B2 (en) * | 1994-07-01 | 1999-03-11 | Procter & Gamble Company, The | Desquamation compositions |
| JPH08190187A (ja) * | 1995-01-11 | 1996-07-23 | Canon Inc | 情報記録装置 |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| US6187817B1 (en) * | 1996-10-03 | 2001-02-13 | Southern Illinois University School Of Medicine | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
| EP0930877B1 (en) * | 1996-10-03 | 2006-04-19 | Southern Illinois University | D-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
| ES2338946T3 (es) * | 1998-02-13 | 2010-05-13 | Nutramax Laboratories, Inc. | Agentes y procedimientos para la proteccion, tratamiento y reparacion del tejido conjuntivo. |
| DK1194161T3 (da) * | 1999-07-13 | 2006-02-13 | Biovitrum Ab | Stabile faktor VIII-sammensatninger |
| AU2002249863A1 (en) * | 2000-10-24 | 2002-08-12 | Diatide, Inc. | Stabilization of radiopharmaceutical compositions using hydrophilic thioether or a hydrophilic 6-hydroxy chroman |
| MXPA03004546A (es) * | 2000-11-22 | 2003-09-10 | Rxkinetix Inc | Tratamiento de mucositis. |
| PL363426A1 (en) * | 2001-03-09 | 2004-11-15 | Societe Des Produits Nestle S.A. | Composition improving age-related physiological deficits and increasing longevity |
| KR100949318B1 (ko) * | 2001-11-29 | 2010-03-23 | 사운드 파마슈티칼스 인코퍼레이티드 | 화학요법의 바람직하지 않은 작용을 개선하기 위한 방법과조성물 |
| US20040198841A1 (en) * | 2003-03-13 | 2004-10-07 | Oregon Health & Science University | Use of thiol-based compositions in ameliorating mucosal injury |
| CA2581076A1 (en) * | 2004-09-14 | 2006-03-23 | Molecular Therapeutics, Inc. | D-methionine formulation with improved biopharmaceutical properties |
-
2003
- 2003-10-27 US US10/694,436 patent/US20050090551A1/en not_active Abandoned
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2004
- 2004-10-27 AU AU2004283756A patent/AU2004283756B2/en not_active Ceased
- 2004-10-27 AT AT04810055T patent/ATE536178T1/de active
- 2004-10-27 WO PCT/US2004/035626 patent/WO2005039554A2/en not_active Ceased
- 2004-10-27 ES ES04810055T patent/ES2376102T3/es not_active Expired - Lifetime
- 2004-10-27 JP JP2006538213A patent/JP4884974B2/ja not_active Expired - Fee Related
- 2004-10-27 EP EP04810055A patent/EP1677775B1/en not_active Expired - Lifetime
- 2004-10-27 CA CA2543870A patent/CA2543870C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE536178T1 (de) | 2011-12-15 |
| ES2376102T3 (es) | 2012-03-09 |
| EP1677775B1 (en) | 2011-12-07 |
| US20050090551A1 (en) | 2005-04-28 |
| JP2007509955A (ja) | 2007-04-19 |
| AU2004283756A2 (en) | 2005-05-06 |
| EP1677775A2 (en) | 2006-07-12 |
| AU2004283756A1 (en) | 2005-05-06 |
| CA2543870A1 (en) | 2005-05-06 |
| AU2004283756B2 (en) | 2010-07-29 |
| JP4884974B2 (ja) | 2012-02-29 |
| WO2005039554A2 (en) | 2005-05-06 |
| WO2005039554A3 (en) | 2005-12-15 |
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