JP4874525B2 - 多糖ビーズの製造 - Google Patents

多糖ビーズの製造 Download PDF

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Publication number
JP4874525B2
JP4874525B2 JP2003587868A JP2003587868A JP4874525B2 JP 4874525 B2 JP4874525 B2 JP 4874525B2 JP 2003587868 A JP2003587868 A JP 2003587868A JP 2003587868 A JP2003587868 A JP 2003587868A JP 4874525 B2 JP4874525 B2 JP 4874525B2
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JP
Japan
Prior art keywords
vapor pressure
beads
polysaccharide
agarose
solution
Prior art date
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Expired - Lifetime
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JP2003587868A
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English (en)
Japanese (ja)
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JP2005523963A (ja
JP2005523963A5 (https=
Inventor
アンダーソン，ラルフ・ゴラン
ベルグ，ハンス
イェンソン，インゲマル
ラルソン，アンダース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Amersham Bioscience AB
GE Healthcare Bio Sciences Corp
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Publication date
Application filed by Amersham Bioscience AB, GE Healthcare Bio Sciences Corp filed Critical Amersham Bioscience AB
Publication of JP2005523963A publication Critical patent/JP2005523963A/ja
Publication of JP2005523963A5 publication Critical patent/JP2005523963A5/ja
Application granted granted Critical
Publication of JP4874525B2 publication Critical patent/JP4874525B2/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/18—Macromolecular compounds
    • B01J39/19—Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/12—Agar-agar; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2003587868A 2002-04-25 2003-04-17 多糖ビーズの製造 Expired - Lifetime JP4874525B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0201289-6 2002-04-25
SE0201289A SE0201289D0 (sv) 2002-04-25 2002-04-25 Manufacture of polysaccharide beads
PCT/SE2003/000629 WO2003091315A1 (en) 2002-04-25 2003-04-17 Manufacture of polysaccharide beads

Publications (3)

Publication Number Publication Date
JP2005523963A JP2005523963A (ja) 2005-08-11
JP2005523963A5 JP2005523963A5 (https=) 2009-05-07
JP4874525B2 true JP4874525B2 (ja) 2012-02-15

Family

ID=20287716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003587868A Expired - Lifetime JP4874525B2 (ja) 2002-04-25 2003-04-17 多糖ビーズの製造

Country Status (8)

Country Link
US (1) US7341682B2 (https=)
EP (1) EP1497358B1 (https=)
JP (1) JP4874525B2 (https=)
AU (1) AU2003224554B2 (https=)
CA (1) CA2480313C (https=)
NZ (1) NZ535316A (https=)
SE (1) SE0201289D0 (https=)
WO (1) WO2003091315A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904344D0 (sv) * 1999-12-01 1999-12-01 Ralf Goeran Andersson Method of producing porous spherical particles
GB2407783A (en) * 2003-11-07 2005-05-11 Novexin Ltd Chromatographic separation
WO2005079970A1 (en) * 2004-02-23 2005-09-01 Eyesense Ag Process for production of ionically crosslinked polysaccharide microspheres
RU2411081C2 (ru) * 2005-07-06 2011-02-10 Джи-И Хелткер Байо-Сайенсиз АБ Способ изготовления разделяющей матрицы
US20100111816A1 (en) * 2007-03-30 2010-05-06 Powdertech Co., Ltd. Inorganic particle-containing emulsion and manufacturing method of a particle by using the inorganic particle-containing emulsion
WO2009099375A1 (en) 2008-02-05 2009-08-13 Ge Healthcare Bio-Sciences Ab Method for production of separation media
CN106140038B (zh) * 2015-04-08 2019-07-12 通用电气公司 制备聚合物微粒的方法和装置
CN107537412B (zh) 2016-06-27 2021-06-01 思拓凡生物工艺研发有限公司 制备聚合物微球的方法和系统
GB201718031D0 (en) * 2017-11-01 2017-12-13 British American Tobacco Investments Ltd Aerosolisable gel
GB2573133A (en) * 2018-04-25 2019-10-30 Ge Healthcare Bioprocess R&D Ab Separation matrix and method of separation
CN117957056A (zh) * 2021-09-17 2024-04-30 阿斯特里亚英国服务有限公司 用于制备多孔聚合物颗粒的制剂
WO2023113484A1 (ko) * 2021-12-15 2023-06-22 (주)바이오제닉스 졸-겔 전이 거동을 가지는 다당체 및 폴리올을 포함하는 분쇄성 다당체 비드 및 이의 제조방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53144962A (en) * 1977-05-23 1978-12-16 Tanabe Seiyaku Co Ltd Production of beads of polysaccharide gels
JPH05222208A (ja) * 1992-02-10 1993-08-31 Nisshinbo Ind Inc 高分子真球状粒子及び製造方法
JPH09220460A (ja) * 1995-12-14 1997-08-26 Takeda Chem Ind Ltd 冷却造粒方法およびその装置
US5662840A (en) * 1994-06-10 1997-09-02 Fmc Corporation Process for making gel microbeads
US6248268B1 (en) * 1998-11-16 2001-06-19 Xc Corporation Process of making microparticles of a thermally-gelled polysaccharide
WO2002012374A1 (en) * 2000-08-03 2002-02-14 Prometic Biosciences Inc. Apparatus and method for producing porous polymer particles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887901A (https=) * 1960-04-13 1900-01-01
US4242298A (en) * 1979-07-09 1980-12-30 Beckman Instruments, Inc. Polysaccharide ester membrane clearing process
US5718969A (en) 1993-08-25 1998-02-17 Fmc Corporation Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53144962A (en) * 1977-05-23 1978-12-16 Tanabe Seiyaku Co Ltd Production of beads of polysaccharide gels
JPH05222208A (ja) * 1992-02-10 1993-08-31 Nisshinbo Ind Inc 高分子真球状粒子及び製造方法
US5662840A (en) * 1994-06-10 1997-09-02 Fmc Corporation Process for making gel microbeads
JPH09220460A (ja) * 1995-12-14 1997-08-26 Takeda Chem Ind Ltd 冷却造粒方法およびその装置
US6248268B1 (en) * 1998-11-16 2001-06-19 Xc Corporation Process of making microparticles of a thermally-gelled polysaccharide
WO2002012374A1 (en) * 2000-08-03 2002-02-14 Prometic Biosciences Inc. Apparatus and method for producing porous polymer particles
JP2004506081A (ja) * 2000-08-03 2004-02-26 プロメティック、バイオサイエンシーズ、インコーポレーテッド 多孔質ポリマー粒子を製造する装置及び方法

Also Published As

Publication number Publication date
JP2005523963A (ja) 2005-08-11
EP1497358A1 (en) 2005-01-19
NZ535316A (en) 2006-09-29
US20050179151A1 (en) 2005-08-18
US7341682B2 (en) 2008-03-11
EP1497358B1 (en) 2016-06-08
WO2003091315A1 (en) 2003-11-06
SE0201289D0 (sv) 2002-04-25
CA2480313C (en) 2011-06-14
AU2003224554B2 (en) 2008-06-12
CA2480313A1 (en) 2003-11-06
AU2003224554A1 (en) 2003-11-10

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