CA2480313C - Manufacture of polysaccharide beads - Google Patents

Manufacture of polysaccharide beads Download PDF

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Publication number
CA2480313C
CA2480313C CA2480313A CA2480313A CA2480313C CA 2480313 C CA2480313 C CA 2480313C CA 2480313 A CA2480313 A CA 2480313A CA 2480313 A CA2480313 A CA 2480313A CA 2480313 C CA2480313 C CA 2480313C
Authority
CA
Canada
Prior art keywords
polysaccharide
beads
vapour pressure
process according
lowering agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2480313A
Other languages
English (en)
French (fr)
Other versions
CA2480313A1 (en
Inventor
Ralf Goeran Andersson
Hans Berg
Ingemar Jonsson
Anders Larsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Bioprocess R&D AB
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of CA2480313A1 publication Critical patent/CA2480313A1/en
Application granted granted Critical
Publication of CA2480313C publication Critical patent/CA2480313C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/18—Macromolecular compounds
    • B01J39/19—Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/12—Agar-agar; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CA2480313A 2002-04-25 2003-04-17 Manufacture of polysaccharide beads Expired - Lifetime CA2480313C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0201289-6 2002-04-25
SE0201289A SE0201289D0 (sv) 2002-04-25 2002-04-25 Manufacture of polysaccharide beads
PCT/SE2003/000629 WO2003091315A1 (en) 2002-04-25 2003-04-17 Manufacture of polysaccharide beads

Publications (2)

Publication Number Publication Date
CA2480313A1 CA2480313A1 (en) 2003-11-06
CA2480313C true CA2480313C (en) 2011-06-14

Family

ID=20287716

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2480313A Expired - Lifetime CA2480313C (en) 2002-04-25 2003-04-17 Manufacture of polysaccharide beads

Country Status (8)

Country Link
US (1) US7341682B2 (https=)
EP (1) EP1497358B1 (https=)
JP (1) JP4874525B2 (https=)
AU (1) AU2003224554B2 (https=)
CA (1) CA2480313C (https=)
NZ (1) NZ535316A (https=)
SE (1) SE0201289D0 (https=)
WO (1) WO2003091315A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904344D0 (sv) * 1999-12-01 1999-12-01 Ralf Goeran Andersson Method of producing porous spherical particles
GB2407783A (en) * 2003-11-07 2005-05-11 Novexin Ltd Chromatographic separation
WO2005079970A1 (en) * 2004-02-23 2005-09-01 Eyesense Ag Process for production of ionically crosslinked polysaccharide microspheres
RU2411081C2 (ru) * 2005-07-06 2011-02-10 Джи-И Хелткер Байо-Сайенсиз АБ Способ изготовления разделяющей матрицы
US20100111816A1 (en) * 2007-03-30 2010-05-06 Powdertech Co., Ltd. Inorganic particle-containing emulsion and manufacturing method of a particle by using the inorganic particle-containing emulsion
WO2009099375A1 (en) 2008-02-05 2009-08-13 Ge Healthcare Bio-Sciences Ab Method for production of separation media
CN106140038B (zh) * 2015-04-08 2019-07-12 通用电气公司 制备聚合物微粒的方法和装置
CN107537412B (zh) 2016-06-27 2021-06-01 思拓凡生物工艺研发有限公司 制备聚合物微球的方法和系统
GB201718031D0 (en) * 2017-11-01 2017-12-13 British American Tobacco Investments Ltd Aerosolisable gel
GB2573133A (en) * 2018-04-25 2019-10-30 Ge Healthcare Bioprocess R&D Ab Separation matrix and method of separation
CN117957056A (zh) * 2021-09-17 2024-04-30 阿斯特里亚英国服务有限公司 用于制备多孔聚合物颗粒的制剂
WO2023113484A1 (ko) * 2021-12-15 2023-06-22 (주)바이오제닉스 졸-겔 전이 거동을 가지는 다당체 및 폴리올을 포함하는 분쇄성 다당체 비드 및 이의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887901A (https=) * 1960-04-13 1900-01-01
JPS53144962A (en) * 1977-05-23 1978-12-16 Tanabe Seiyaku Co Ltd Production of beads of polysaccharide gels
US4242298A (en) * 1979-07-09 1980-12-30 Beckman Instruments, Inc. Polysaccharide ester membrane clearing process
JPH0778126B2 (ja) * 1992-02-10 1995-08-23 日清紡績株式会社 多糖類真球状粒子及び製造方法
US5718969A (en) 1993-08-25 1998-02-17 Fmc Corporation Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation
US5662840A (en) 1994-06-10 1997-09-02 Fmc Corporation Process for making gel microbeads
JPH09220460A (ja) * 1995-12-14 1997-08-26 Takeda Chem Ind Ltd 冷却造粒方法およびその装置
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6248268B1 (en) * 1998-11-16 2001-06-19 Xc Corporation Process of making microparticles of a thermally-gelled polysaccharide
CA2314921A1 (en) * 2000-08-03 2002-02-03 Barry Partington Apparatus and method for producing porous polymer particles

Also Published As

Publication number Publication date
JP2005523963A (ja) 2005-08-11
EP1497358A1 (en) 2005-01-19
NZ535316A (en) 2006-09-29
US20050179151A1 (en) 2005-08-18
US7341682B2 (en) 2008-03-11
EP1497358B1 (en) 2016-06-08
WO2003091315A1 (en) 2003-11-06
SE0201289D0 (sv) 2002-04-25
JP4874525B2 (ja) 2012-02-15
AU2003224554B2 (en) 2008-06-12
CA2480313A1 (en) 2003-11-06
AU2003224554A1 (en) 2003-11-10

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Effective date: 20230417