JP4865838B2 - プリン体吸収抑制組成物 - Google Patents
プリン体吸収抑制組成物 Download PDFInfo
- Publication number
- JP4865838B2 JP4865838B2 JP2009130639A JP2009130639A JP4865838B2 JP 4865838 B2 JP4865838 B2 JP 4865838B2 JP 2009130639 A JP2009130639 A JP 2009130639A JP 2009130639 A JP2009130639 A JP 2009130639A JP 4865838 B2 JP4865838 B2 JP 4865838B2
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- Prior art keywords
- euglena
- purine
- paramylon
- absorption
- processed
- Prior art date
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
Description
ユーグレナのプリン体吸着能を調べた。
まず、ユーグレナ菌体をスプレードライして得られた、ユーグレナ乾燥粉末(株式会社ユーグレナ製)を、前処理した。すなわち、100mgまたは300mgのユーグレナ乾燥粉末を50mLチューブに秤量し、40mLの水を添加して混和、3500rpmで10分遠心し、その上清を除去した。ついで、40mLの水を添加して、懸濁、遠心、上清除去の操作を繰り返し、沈殿残渣物として回収されたユーグレナを以下の試験に用いた。
・試料注入量 10μL
・カラム Hydrosphere C18 4.6×150mm(D) (5μm)
・流速 0.7mL/min
・波長 254nm
・カラム温度 37℃
・移動相 50mM Na2HPO4-H3PO4(pH3.0)
ユーグレナによる血中尿酸値低減効果を調べた。すなわち、20歳以上、65歳未満の健常男子、もしくは試験責任医師が高尿酸血症予備群(境界域)と判断した者で、負荷試験実施2日前から禁酒が可能な4人の被験者を選び、ユーグレナ摂取による血中尿酸値低減の効果について、試験を行った。
ユーグレナを加工処理することによって、そのプリン体吸着能が高められるかどうかを調べた。そのためにまず下記の処理を施したユーグレナ加工処理物を調製した。
(1)処理なし(コントロールとして)
上記ユーグレナ乾燥粉末(株式会社ユーグレナ製)の4gをそのまま凍結乾燥した。
(2)水洗
上記ユーグレナ乾燥粉末(株式会社ユーグレナ製)の4gを、100倍量の純水で洗浄、遠心し、上清を除き、その沈殿を凍結乾燥した。
(3)高圧ホモジナイズ
上記ユーグレナ乾燥粉末(株式会社ユーグレナ製)の4gを、100倍量の純水に懸濁し、高圧ホモジナイズ処理装置(「MV-H LAMB」、株式会社イズミフードマシナリ製)を用いて、50〜110MPaで高圧ホモジナイズした。ホモジナイズ処理した後、遠心し、上清を除き、その沈殿を凍結乾燥した。
(4)Tween+高圧ホモジナイズ
上記ユーグレナ乾燥粉末(株式会社ユーグレナ製)の4gを、0.025%のポリオキシエチレンソルビタンモノラウラート(商品名「Tween20」、アマシャム社製)を含む100倍量の純水に懸濁し、高圧ホモジナイズ処理装置を用いて、30〜50MPaで高圧ホモジナイズした。ホモジナイズ処理した後、遠心し、上清を除き、その沈殿を凍結乾燥した。
Claims (4)
- ユーグレナを高圧破砕処理する工程と、前記高圧破砕処理より得られた破砕物から、可溶性成分を除去する工程と、を行うことにより得られたユーグレナ加工物を有効成分とする、プリン体吸収抑制組成物。
- 前記可溶性成分を除去する工程においては、パラミロン不溶性の溶媒である水又は含水アルコールを用いることにより可溶性成分が除去されることを特徴とする請求項1に記載のプリン体吸収抑制組成物。
- 前記溶媒は、非イオン性界面活性剤であるポリオキシエチレンソルビタン脂肪酸エステルを添加したものである請求項2記載のプリン体吸収抑制組成物。
- 前記ユーグレナ加工物は、固形分中にパラミロンを30質量%以上含むことを特徴とする請求項1に記載のプリン体吸収抑制組成物。
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JPS6437297A (en) * | 1987-08-03 | 1989-02-07 | Harima Chemicals Inc | Production of beta-1,3-glucan |
EP0409488A3 (en) * | 1989-07-17 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Method for producing a heat-gelable beta-1,3-glucan |
JPH0454125A (ja) * | 1990-06-25 | 1992-02-21 | Harima Chem Inc | レトロウイルス感染症治療および予防用薬剤 |
DE59901613D1 (de) * | 1999-02-10 | 2002-07-11 | Suwelack Skin & Health Care Ag | Beta-1,3-Glucan aus Euglena enthaltendes gefriergetrocknetes Erzeugnis, seine Herstellung und Verwendung |
JP4305785B1 (ja) * | 2008-10-15 | 2009-07-29 | 森永製菓株式会社 | プリン体吸収抑制剤及び血中尿酸値低減剤 |
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