JP4854507B2 - 顆粒形状のリン酸カルシウムの調製方法 - Google Patents
顆粒形状のリン酸カルシウムの調製方法 Download PDFInfo
- Publication number
- JP4854507B2 JP4854507B2 JP2006519951A JP2006519951A JP4854507B2 JP 4854507 B2 JP4854507 B2 JP 4854507B2 JP 2006519951 A JP2006519951 A JP 2006519951A JP 2006519951 A JP2006519951 A JP 2006519951A JP 4854507 B2 JP4854507 B2 JP 4854507B2
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- JP
- Japan
- Prior art keywords
- calcium phosphate
- hydroxyapatite
- brushite
- particles
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000001506 calcium phosphate Substances 0.000 title claims description 80
- 235000011010 calcium phosphates Nutrition 0.000 title claims description 80
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 80
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims description 79
- 238000000034 method Methods 0.000 title claims description 49
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 62
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 58
- 239000002245 particle Substances 0.000 claims description 43
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 19
- 239000002585 base Substances 0.000 claims description 15
- 239000000725 suspension Substances 0.000 claims description 14
- 229910019142 PO4 Inorganic materials 0.000 claims description 13
- 239000010452 phosphate Substances 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000003637 basic solution Substances 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 238000002441 X-ray diffraction Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Substances [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 description 40
- 238000007906 compression Methods 0.000 description 26
- 230000006835 compression Effects 0.000 description 26
- 239000000463 material Substances 0.000 description 26
- 239000000546 pharmaceutical excipient Substances 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000004480 active ingredient Substances 0.000 description 19
- 239000000047 product Substances 0.000 description 17
- 239000011575 calcium Substances 0.000 description 16
- 238000007907 direct compression Methods 0.000 description 13
- 238000006460 hydrolysis reaction Methods 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 235000021317 phosphate Nutrition 0.000 description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 11
- 229910052791 calcium Inorganic materials 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- 230000007062 hydrolysis Effects 0.000 description 9
- 239000007900 aqueous suspension Substances 0.000 description 8
- -1 Na + Chemical class 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 150000001450 anions Chemical group 0.000 description 6
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 6
- 150000001768 cations Chemical group 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 239000000920 calcium hydroxide Substances 0.000 description 5
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 239000007884 disintegrant Substances 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 229920002785 Croscarmellose sodium Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 238000005550 wet granulation Methods 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 2
- 240000008886 Ceratonia siliqua Species 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- 101000807533 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 26 Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 description 2
- 102100037180 Ubiquitin carboxyl-terminal hydrolase 26 Human genes 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000005904 alkaline hydrolysis reaction Methods 0.000 description 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 229960001681 croscarmellose sodium Drugs 0.000 description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
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- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 2
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- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
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- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
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- ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/327—After-treatment
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- Chemical & Material Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Environmental & Geological Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Geology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
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- Materials For Medical Uses (AREA)
Description
Ca5-x(PO4)3-x(HPO4)x(OH)1-x(I)
前記式中、xは0から1、好ましくは0.1から0.5の間で変化する。
5CaHPO4−2H2O+4MOH+H2O→Ca5(PO4)3(OH)+2M2HPO4+14H2O
・・・式[I]
式中、Mは、塩基によって供給される陽イオン、好ましくはアルカリ陽イオン、例えばNa+、K+、NH4 +である。pHは、少なくとも7.0、好ましくは7から10、より優先的には8から8.5の間の値に維持される。
見掛け密度は、図6に図示されている装置で測定される。最初に、空の試験管(2)の重量を測定する。測定されるべき粉末を漏斗(1)により試験管(2)へ導入し、粉末層の最上部を、250cm3(水準A)で較正した試験管の高さと同じ高さにする。粉末の重量を、充填した試験管の重量を計ることによって測定する。クランプ(4)を用いて、試験管を支持台(3)上に固定する。
(見掛け密度)=(導入された粉末の質量(g))/(見掛けの体積(cm3))
粒径は、Beckman Coulter(ベックマンコールタ)LS230(登録商標)粒径分析器を使用し、Mie理論を用いて、超音波を掛けず、分散剤を使用しない水性懸濁液のレーザ光回折によって測定する。
全試料の表面積を、BETの一点法およびMicromeritics Flowsorb(登録商標)表面分析装置を使用した窒素吸着により、NF ISO standard 9277に従って測定する。測定の前に、全試料を、200℃の温度で2時間、オーブン内で空気乾燥する。
全試料の流動性能を、Van−Kel(登録商標)流量計、モデル(VK10210)装置により実行した試験によって測定する。
硬度を求めるために、Schleuniger Tablet Hardness Tester(シュロニガ錠剤硬度試験機)(登録商標)、モデル28/106を使用することによって錠剤を試験した。原理は、圧縮顎(compression jaw)の間に錠剤を設置し、錠剤が破壊されるまで力を増しながら加えることに本質がある。力は記録され、錠剤の硬度を表す。示された硬度は、10個の錠剤の平均の硬度である。
粒子の90パーセントが260ミクロン未満であり、粒子の90パーセントが10ミクロンを超える粒径を有するブルッシャイトリン酸カルシウム(DITAB製品、Rhodia社によって調製された)を、40重量%の濃度を有する水性懸濁液が得られるような量で、水が循環している二重壁反応器に、周囲温度で充填する。
温度を90℃に維持することを除いて、参考例1に記載されているのと、同一の処理を実行する。
使用した塩基が20%の水酸化ナトリウム水溶液であることを除いて、実施例2に記載されているのと、同一の処理を実行する。
使用した塩基が30%の水酸化カリウム水溶液であることを除いて、実施例3に記載されているのと、同一の処理を実行する。
12%の水酸化カルシウム懸濁液(重量/重量)を反応器に充填すること、60℃で懸濁液を充填すること、および次いで、その結果得られた懸濁液のpHが6から7の間になるまで、石灰の懸濁液に20%H3PO4の溶液を添加することからなる標準の方法により、ヒドロキシアパタイトリン酸カルシウムを調製する。
添付の図1〜3は、本発明の実施例2によるヒドロキシアパタイトリン酸カルシウム(図1)、原料、すなわち、ブルッシャイトリン酸カルシウム(図2)、および比較例5に記載の従来技術により調製したヒドロキシアパタイトリン酸カルシウム(図3)の顆粒の形態を示す。図4は、さまざまな実施例の中位径(d50)を測定するための累積曲線に対応するグラフを示す。図5は、さまざまな実施例の粒径分布を説明するグラフを表す。
ヒドロキシアパタイトリン酸カルシウム(97パーセントの比率で)、2%のAc−Di−Sol(登録商標)(ステアリン酸クロスカルメロース)崩壊剤および0.5%のステアリン酸マグネシウム滑沢剤を、強化バー(intensification bar)を装備した2つの胴部を有するV型混合機(Pattern Kelley(登録商標))に入れることにより、上の実施例の錠剤を調製する。
Claims (9)
- ヒドロキシアパタイトのX線回折パターンを示すとともに、粒子の90重量%が300ミクロン未満、粒子の90重量%が10ミクロンを超える粒径を有する、顆粒形状のリン酸カルシウムの調製方法であって、
(a)粒子の90重量%が300ミクロン未満、粒子の90重量%が10ミクロンを超える粒径を有する、ブルッシャイトリン酸カルシウムの懸濁液を、塩基性溶液を用いて、pHを7.0〜10.0の間に維持するとともに、反応温度が60℃〜90℃で、処理することと、
(b)ブルッシャイトリン酸カルシウムのヒドロキシアパタイトリン酸カルシウムへの変換を可能にするのに十分な時間の間、pHを7.0以上に維持することと、
を含み、
前記(a)、(b)の処理を経た水溶液から固形物を分離して、乾燥することによって顆粒形状のリン酸カルシウムを得ることを特徴とする、顆粒形状のリン酸カルシウムの調製方法。 - 請求項1記載の方法であって、ブルッシャイトリン酸カルシウムの粒子の寸法が、中位径(d50)が100μm〜250μmの間にあることを特徴とする方法。
- 請求項1記載の方法であって、前記塩基性溶液に使用される塩基が、NaOH、KOH、NH4OHの中から選択されることを特徴とする方法。
- 請求項1記載の方法であって、ブルッシャイトリン酸カルシウムについての化学量論量の80〜110%となるように塩基性溶液が添加されることを特徴とする方法。
- 請求項1記載の方法であって、最初に、ブルッシャイトリン酸カルシウムの水溶液を、選択した反応温度に加熱し、次いで、pHを制御しながら塩基性溶液を導入することを特徴とする方法。
- 請求項1記載の方法であって、最初に、pHを制御するために塩基性溶液を添加し、次いで、媒質を選択した反応温度に加熱することを特徴とする方法。
- 請求項5または請求項6記載の方法であって、前記懸濁液のpH値を監視してそのpH値を所定の範囲に維持しながら、塩基性溶液を添加することを特徴とする方法。
- 請求項1記載の方法であって、ヒドロキシアパタイトリン酸カルシウムを、濾過または遠心分離によって、水溶液から分離することを特徴とする方法。
- 請求項1に記載の方法であって、ヒドロキシアパタイトリン酸カルシウムを、80〜120℃の間において乾燥させることを特徴とする方法。
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FR0308660A FR2857658B1 (fr) | 2003-07-16 | 2003-07-16 | Nouveaux granules de phosphates de calcium de type hydroxyapatite, leur procede de preparation et leurs applications |
FR03/08660 | 2003-07-16 | ||
PCT/FR2004/001790 WO2005007599A2 (fr) | 2003-07-16 | 2004-07-08 | Granules de phosphates de calcium de type hydroxyapatite et leur procede de preparation et leurs applications |
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JP2007528833A JP2007528833A (ja) | 2007-10-18 |
JP4854507B2 true JP4854507B2 (ja) | 2012-01-18 |
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JP2006519951A Expired - Fee Related JP4854507B2 (ja) | 2003-07-16 | 2004-07-08 | 顆粒形状のリン酸カルシウムの調製方法 |
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US (2) | US20070183955A1 (ja) |
EP (1) | EP1654195B1 (ja) |
JP (1) | JP4854507B2 (ja) |
CN (1) | CN1852862B (ja) |
AU (1) | AU2004256947B2 (ja) |
BR (1) | BRPI0412580A (ja) |
CA (1) | CA2533018C (ja) |
FR (1) | FR2857658B1 (ja) |
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WO (1) | WO2005007599A2 (ja) |
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FR2869893B1 (fr) | 2004-05-06 | 2006-07-28 | Rhodia Chimie Sa | Nouveaux granules de phosphates de calcium de type hydroxyapatite, leur procede de preparation et leurs applications |
PL210026B1 (pl) | 2009-03-17 | 2011-11-30 | Akademia Górniczo Hutnicza Im Stanisława Staszica | Sposób wytwarzania wysokoporowatego, fosforanowo-wapniowego bioaktywnego tworzywa implantacyjnego |
JP5724050B2 (ja) | 2009-09-28 | 2015-05-27 | Hoya株式会社 | 粉体、粉体の製造方法、吸着装置 |
US20120227663A1 (en) * | 2011-03-08 | 2012-09-13 | Purdue Research Foundation | Oxide metal semiconductor superlattices for thermoelectrics |
FR3021045B1 (fr) * | 2014-05-16 | 2020-02-21 | Solvay Sa | Procede de production d'un reactif phosphocalcique, reactif obtenu et son utilisation |
CN107619031B (zh) * | 2016-10-11 | 2021-04-23 | 西南交通大学 | 磷酸根离子基颗粒的制备方法 |
JP6936450B2 (ja) * | 2017-05-19 | 2021-09-15 | 富士通株式会社 | 光触媒、及びその製造方法、部材、並びに装置 |
DE102019109143A1 (de) * | 2019-04-08 | 2020-10-08 | Chemische Fabrik Budenheim Kg | Hydroxylapatit-Pulver und Verfahren zu dessen Herstellung |
JP6993481B1 (ja) | 2020-08-31 | 2022-01-13 | 新田ゼラチン株式会社 | 改質リン酸水素カルシウム二水和物の製造方法 |
WO2024200015A1 (en) * | 2023-03-28 | 2024-10-03 | Evonik Operations Gmbh | Process for the production of a granulate and a granulate, in particular a granulate compound of excipients |
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JPS6246908A (ja) * | 1985-08-23 | 1987-02-28 | Natl Inst For Res In Inorg Mater | 水酸アパタイトの製造方法 |
JPS62202808A (ja) * | 1986-01-30 | 1987-09-07 | Koken:Kk | クロマトグラフイ−用ハイドロキシアパタイト結晶粒子の製造方法 |
JPH03218911A (ja) * | 1990-01-23 | 1991-09-26 | Japan Steel Works Ltd:The | 水酸アパタイトの製造方法及びその装置 |
WO2002089775A1 (fr) * | 2001-05-09 | 2002-11-14 | Ethypharm | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'angiotensine |
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US3987204A (en) * | 1972-09-15 | 1976-10-19 | Sucrest Corporation | Direct compression vehicle |
GB2025912A (en) * | 1978-07-21 | 1980-01-30 | Spencer M | Process for preparing a crystalline form of calcium phosphate |
US5066441A (en) * | 1980-12-12 | 1991-11-19 | Rhone-Poulenc Basic Chemicals Co. | Process for compacting a calcium phosphate composition |
US4781925A (en) * | 1986-03-06 | 1988-11-01 | American Home Products Corporation | Calcium supplement compressed tablets |
JPH072506A (ja) * | 1993-06-11 | 1995-01-06 | Taihei Kagaku Sangyo Kk | 針状ヒドロキシアパタイトの製造方法 |
JP2700141B2 (ja) * | 1993-09-17 | 1998-01-19 | 富士化学工業株式会社 | リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤 |
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2003
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2004
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- 2004-07-08 CN CN2004800265810A patent/CN1852862B/zh not_active Expired - Fee Related
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- 2004-07-08 WO PCT/FR2004/001790 patent/WO2005007599A2/fr active Application Filing
- 2004-07-08 AU AU2004256947A patent/AU2004256947B2/en not_active Ceased
- 2004-07-08 EP EP04767622.6A patent/EP1654195B1/fr not_active Expired - Lifetime
- 2004-08-16 US US10/564,905 patent/US20070183955A1/en not_active Abandoned
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JPS6246908A (ja) * | 1985-08-23 | 1987-02-28 | Natl Inst For Res In Inorg Mater | 水酸アパタイトの製造方法 |
JPS62202808A (ja) * | 1986-01-30 | 1987-09-07 | Koken:Kk | クロマトグラフイ−用ハイドロキシアパタイト結晶粒子の製造方法 |
JPH03218911A (ja) * | 1990-01-23 | 1991-09-26 | Japan Steel Works Ltd:The | 水酸アパタイトの製造方法及びその装置 |
WO2002089775A1 (fr) * | 2001-05-09 | 2002-11-14 | Ethypharm | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'angiotensine |
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WO2005007599A3 (fr) | 2005-07-28 |
US20070183955A1 (en) | 2007-08-09 |
EP1654195B1 (fr) | 2016-06-15 |
US8414857B2 (en) | 2013-04-09 |
NZ545110A (en) | 2010-03-26 |
CN1852862A (zh) | 2006-10-25 |
JP2007528833A (ja) | 2007-10-18 |
CN1852862B (zh) | 2012-04-25 |
WO2005007599A2 (fr) | 2005-01-27 |
FR2857658A1 (fr) | 2005-01-21 |
CA2533018A1 (en) | 2005-01-27 |
CA2533018C (en) | 2010-12-21 |
FR2857658B1 (fr) | 2006-09-22 |
BRPI0412580A (pt) | 2006-09-19 |
EP1654195A2 (fr) | 2006-05-10 |
AU2004256947B2 (en) | 2009-01-22 |
US20100150806A1 (en) | 2010-06-17 |
AU2004256947A1 (en) | 2005-01-27 |
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