JP4846099B2 - インビボでの酸化窒素送達用ポリマー - Google Patents
インビボでの酸化窒素送達用ポリマー Download PDFInfo
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- JP4846099B2 JP4846099B2 JP2000555946A JP2000555946A JP4846099B2 JP 4846099 B2 JP4846099 B2 JP 4846099B2 JP 2000555946 A JP2000555946 A JP 2000555946A JP 2000555946 A JP2000555946 A JP 2000555946A JP 4846099 B2 JP4846099 B2 JP 4846099B2
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- polymer
- nitrosylated
- polysaccharide
- compound
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- 229920000642 polymer Polymers 0.000 title claims description 162
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- 238000001727 in vivo Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims description 58
- 229920001282 polysaccharide Polymers 0.000 claims description 58
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- 239000000178 monomer Substances 0.000 claims description 15
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- 238000000576 coating method Methods 0.000 claims description 11
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- 238000004519 manufacturing process Methods 0.000 claims description 7
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- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
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- 235000011175 beta-cyclodextrine Nutrition 0.000 description 31
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- KEJOCWOXCDWNID-UHFFFAOYSA-N Nitrilooxonium Chemical class [O+]#N KEJOCWOXCDWNID-UHFFFAOYSA-N 0.000 description 4
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- PMYJGTWUVVVOFO-UHFFFAOYSA-N 4-phenyl-3-furoxancarbonitrile Chemical compound N#CC1=[N+]([O-])ON=C1C1=CC=CC=C1 PMYJGTWUVVVOFO-UHFFFAOYSA-N 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 2
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- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/103,225 US6232434B1 (en) | 1996-08-02 | 1998-06-23 | Polymers for delivering nitric oxide in vivo |
| US09/103,225 | 1998-06-23 | ||
| PCT/US1999/013731 WO1999067296A1 (en) | 1998-06-23 | 1999-06-17 | Polymers for delivering nitric oxide in vivo |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011011097A Division JP2011144376A (ja) | 1998-06-23 | 2011-01-21 | インビボでの酸化窒素送達用ポリマー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002518557A JP2002518557A (ja) | 2002-06-25 |
| JP2002518557A5 JP2002518557A5 (https=) | 2006-08-10 |
| JP4846099B2 true JP4846099B2 (ja) | 2011-12-28 |
Family
ID=22294044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000555946A Expired - Fee Related JP4846099B2 (ja) | 1998-06-23 | 1999-06-17 | インビボでの酸化窒素送達用ポリマー |
| JP2011011097A Pending JP2011144376A (ja) | 1998-06-23 | 2011-01-21 | インビボでの酸化窒素送達用ポリマー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011011097A Pending JP2011144376A (ja) | 1998-06-23 | 2011-01-21 | インビボでの酸化窒素送達用ポリマー |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US6232434B1 (https=) |
| EP (1) | EP1093468B1 (https=) |
| JP (2) | JP4846099B2 (https=) |
| AU (1) | AU4692999A (https=) |
| CA (1) | CA2336138C (https=) |
| DE (1) | DE69934406T2 (https=) |
| ES (1) | ES2279621T3 (https=) |
| WO (1) | WO1999067296A1 (https=) |
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| GB9423868D0 (en) | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
| GB9424694D0 (en) | 1994-12-07 | 1995-02-01 | Wellcome Found | Compounds for use in medicine |
| KR100434238B1 (ko) | 1995-03-14 | 2004-07-16 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 경관팽창및신장조절을위한산화질소공여체또는산화질소억제제의용도 |
| US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
-
1998
- 1998-06-23 US US09/103,225 patent/US6232434B1/en not_active Expired - Fee Related
-
1999
- 1999-06-17 WO PCT/US1999/013731 patent/WO1999067296A1/en not_active Ceased
- 1999-06-17 CA CA2336138A patent/CA2336138C/en not_active Expired - Fee Related
- 1999-06-17 DE DE69934406T patent/DE69934406T2/de not_active Expired - Lifetime
- 1999-06-17 EP EP99930378A patent/EP1093468B1/en not_active Expired - Lifetime
- 1999-06-17 ES ES99930378T patent/ES2279621T3/es not_active Expired - Lifetime
- 1999-06-17 AU AU46929/99A patent/AU4692999A/en not_active Abandoned
- 1999-06-17 JP JP2000555946A patent/JP4846099B2/ja not_active Expired - Fee Related
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2000
- 2000-12-29 US US09/752,223 patent/US6403759B2/en not_active Expired - Fee Related
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2002
- 2002-06-05 US US10/164,366 patent/US6673891B2/en not_active Expired - Fee Related
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2003
- 2003-09-23 US US10/668,667 patent/US6875840B2/en not_active Expired - Fee Related
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2005
- 2005-02-08 US US11/053,593 patent/US7087709B2/en not_active Expired - Fee Related
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2006
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2011
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989012627A1 (en) * | 1988-06-15 | 1989-12-28 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
| WO1996003139A1 (en) * | 1994-07-27 | 1996-02-08 | Duke University | Use of nitric oxide or nitric oxide adducts to preserve platelets |
| WO1998005689A1 (en) * | 1996-08-02 | 1998-02-12 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1093468B1 (en) | 2006-12-13 |
| US6232434B1 (en) | 2001-05-15 |
| JP2002518557A (ja) | 2002-06-25 |
| JP2011144376A (ja) | 2011-07-28 |
| US20050220756A1 (en) | 2005-10-06 |
| CA2336138A1 (en) | 1999-12-29 |
| US6403759B2 (en) | 2002-06-11 |
| US6673891B2 (en) | 2004-01-06 |
| ES2279621T3 (es) | 2007-08-16 |
| AU4692999A (en) | 2000-01-10 |
| US20030078365A1 (en) | 2003-04-24 |
| EP1093468A1 (en) | 2001-04-25 |
| US7087709B2 (en) | 2006-08-08 |
| US20070088435A1 (en) | 2007-04-19 |
| CA2336138C (en) | 2011-08-23 |
| DE69934406T2 (de) | 2007-09-27 |
| US20010020083A1 (en) | 2001-09-06 |
| DE69934406D1 (de) | 2007-01-25 |
| US7417109B2 (en) | 2008-08-26 |
| WO1999067296A1 (en) | 1999-12-29 |
| US6875840B2 (en) | 2005-04-05 |
| US20040132904A1 (en) | 2004-07-08 |
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