JP4827737B2 - アミロイド関連疾患の処置のためのピリジニル−ピリミジニルアミノ−ベンズアミド誘導体の使用 - Google Patents
アミロイド関連疾患の処置のためのピリジニル−ピリミジニルアミノ−ベンズアミド誘導体の使用 Download PDFInfo
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- JP4827737B2 JP4827737B2 JP2006536068A JP2006536068A JP4827737B2 JP 4827737 B2 JP4827737 B2 JP 4827737B2 JP 2006536068 A JP2006536068 A JP 2006536068A JP 2006536068 A JP2006536068 A JP 2006536068A JP 4827737 B2 JP4827737 B2 JP 4827737B2
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- methyl
- amino
- benzamide
- pyridinyl
- phenyl
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0325031.3A GB0325031D0 (en) | 2003-10-27 | 2003-10-27 | Organic compounds |
| GB0325031.3 | 2003-10-27 | ||
| PCT/EP2004/012080 WO2005039586A1 (en) | 2003-10-27 | 2004-10-26 | Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007509106A JP2007509106A (ja) | 2007-04-12 |
| JP2007509106A5 JP2007509106A5 (https=) | 2007-12-13 |
| JP4827737B2 true JP4827737B2 (ja) | 2011-11-30 |
Family
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Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7687512B2 (https=) |
| JP (1) | JP4827737B2 (https=) |
| GB (1) | GB0325031D0 (https=) |
| WO (1) | WO2005039586A1 (https=) |
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| KR20070107022A (ko) | 2005-01-07 | 2007-11-06 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| ES2373912T3 (es) * | 2005-01-28 | 2012-02-10 | Novartis Ag | Uso de pirimidilaminobenzamidas para el tratamiento de enfermedades que responden a la modulación de la actividad de quinasa tie-2. |
| MX2007013738A (es) * | 2005-05-02 | 2008-01-24 | Novartis Ag | Derivados de pirimidilaminobenzamida para sindrome hipereosinofilico. |
| GT200600315A (es) * | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| ES2549327T3 (es) | 2005-12-06 | 2015-10-27 | Novartis Ag | Derivados de pirimidilaminobenzamida para el tratamiento de la neurofibromatosis |
| WO2007076875A2 (en) * | 2006-01-06 | 2007-07-12 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| US7683060B2 (en) | 2006-08-07 | 2010-03-23 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| MX2009004314A (es) | 2006-11-13 | 2009-05-05 | Pfizer Prod Inc | Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos. |
| ME02372B (me) | 2006-11-22 | 2016-06-20 | Incyte Holdings Corp | Imidazotriazini i imidazopiramidini kao inhibitori kinaze |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| US8242271B2 (en) | 2007-06-04 | 2012-08-14 | Avila Therapeutics, Inc. | Heterocyclic compounds and uses thereof |
| ES2607794T3 (es) * | 2007-06-07 | 2017-04-04 | Intra-Cellular Therapies, Inc. | Compuestos heterocíclicos novedosos y usos de los mismos |
| WO2008153959A1 (en) * | 2007-06-07 | 2008-12-18 | Intra-Cellular Therapies, Inc. | Novel heterocycle compounds and uses thereof |
| WO2009036066A1 (en) * | 2007-09-10 | 2009-03-19 | Curis, Inc. | Vegfr inhibitors containing a zinc binding moiety |
| WO2009143211A2 (en) | 2008-05-21 | 2009-11-26 | Incyte Corporation | Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same |
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| BRPI0917491A2 (pt) * | 2008-08-13 | 2015-12-01 | Novartis Ag | tratamento de hipertensao arterial pulmonar |
| US20110243957A1 (en) * | 2008-09-24 | 2011-10-06 | University Of South Florida | Materials and methods for preventing or treating neurodegenerative conditions associated with abeta peptide accumulation |
| EP2340244A4 (en) * | 2008-10-14 | 2012-07-25 | Ning Xi | COMPOUNDS AND APPLICATION PROCEDURES |
| EP2262793B1 (en) | 2008-11-05 | 2012-10-03 | Teva Pharmaceutical Industries Ltd. | Nilotinib hci crystalline forms |
| WO2010060074A1 (en) * | 2008-11-24 | 2010-05-27 | Teva Pharmaceutical Industries Ltd. | Preparation of nilotinib and intermediates thereof |
| CN102316738A (zh) * | 2009-02-18 | 2012-01-11 | 盛泰萨路申有限公司 | 作为激酶抑制剂的酰胺类 |
| ES2578990T3 (es) * | 2009-03-21 | 2016-08-03 | Sunshine Lake Pharma Co., Ltd. | Derivados de amino éster, sales de los mismos y métodos de uso |
| SG178279A1 (en) | 2009-08-05 | 2012-03-29 | Intra Cellular Therapies Inc | Novel regulatory proteins and inhibitors |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| EA025304B1 (ru) | 2010-02-03 | 2016-12-30 | Инсайт Холдингс Корпорейшн | ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ |
| EP2554163A4 (en) * | 2010-03-26 | 2013-07-17 | Univ Hokkaido Nat Univ Corp | THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES |
| EP2736904B1 (en) | 2011-07-27 | 2016-03-16 | AB Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
| WO2013166295A1 (en) | 2012-05-02 | 2013-11-07 | Georgetown University | Treating neural disease with tyrosine kinase inhibitors |
| EP3080103B9 (en) * | 2013-12-11 | 2018-09-19 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| EP3275440B1 (en) | 2015-03-25 | 2022-05-04 | National Center for Geriatrics and Gerontology | Novel oxadiazole derivative and pharmaceutical containing same |
| CN105030776A (zh) * | 2015-06-24 | 2015-11-11 | 北京键凯科技有限公司 | Src蛋白抑制剂在制备预防和/治疗阿尔兹海默病药物中的应用 |
| CN106905298A (zh) * | 2015-12-22 | 2017-06-30 | 江苏先声药业有限公司 | 盐酸尼洛替尼杂质的制备方法 |
| US11426406B2 (en) | 2017-02-09 | 2022-08-30 | Georgetown University | Compositions and methods for treating lysosomal storage disorders |
| WO2018207154A1 (en) * | 2017-05-12 | 2018-11-15 | The Hong Kong University Of Science And Technology | Heterocyclic compounds as epha4 inhibitors |
| WO2020056132A1 (en) * | 2018-09-13 | 2020-03-19 | University Of Southern California | Novel fgfr inhibitors and uses thereof |
| JP7629200B2 (ja) | 2018-11-20 | 2025-02-13 | ジョージタウン ユニバーシティ | 神経変性、筋変性及びリソソーム蓄積障害を治療するための組成物及び方法 |
| CA3132730A1 (en) * | 2019-03-05 | 2020-09-10 | Hongyi & Associates Llc | Compounds for treating neurodegenerative diseases and cancers |
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| WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| KR100330553B1 (ko) | 1993-10-01 | 2002-11-27 | 노파르티스 아게 | 약물학적활성피리딘유도체및그의제조방법 |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
-
2003
- 2003-10-27 GB GBGB0325031.3A patent/GB0325031D0/en not_active Ceased
-
2004
- 2004-10-26 JP JP2006536068A patent/JP4827737B2/ja not_active Expired - Fee Related
- 2004-10-26 US US10/576,175 patent/US7687512B2/en not_active Expired - Fee Related
- 2004-10-26 WO PCT/EP2004/012080 patent/WO2005039586A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0325031D0 (en) | 2003-12-03 |
| JP2007509106A (ja) | 2007-04-12 |
| WO2005039586A1 (en) | 2005-05-06 |
| US20070129389A1 (en) | 2007-06-07 |
| US7687512B2 (en) | 2010-03-30 |
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