JP4827737B2 - アミロイド関連疾患の処置のためのピリジニル−ピリミジニルアミノ−ベンズアミド誘導体の使用 - Google Patents
アミロイド関連疾患の処置のためのピリジニル−ピリミジニルアミノ−ベンズアミド誘導体の使用 Download PDFInfo
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- JP4827737B2 JP4827737B2 JP2006536068A JP2006536068A JP4827737B2 JP 4827737 B2 JP4827737 B2 JP 4827737B2 JP 2006536068 A JP2006536068 A JP 2006536068A JP 2006536068 A JP2006536068 A JP 2006536068A JP 4827737 B2 JP4827737 B2 JP 4827737B2
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- methyl
- amino
- benzamide
- pyridinyl
- phenyl
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0325031.3 | 2003-10-27 | ||
| GBGB0325031.3A GB0325031D0 (en) | 2003-10-27 | 2003-10-27 | Organic compounds |
| PCT/EP2004/012080 WO2005039586A1 (en) | 2003-10-27 | 2004-10-26 | Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders |
Publications (3)
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| JP2007509106A JP2007509106A (ja) | 2007-04-12 |
| JP2007509106A5 JP2007509106A5 (cg-RX-API-DMAC7.html) | 2007-12-13 |
| JP4827737B2 true JP4827737B2 (ja) | 2011-11-30 |
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| JP (1) | JP4827737B2 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0325031D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005039586A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006083477A2 (en) | 2005-01-07 | 2006-08-10 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| CN101203224B (zh) * | 2005-01-28 | 2010-11-03 | 诺瓦提斯公司 | 嘧啶基氨基苯甲酰胺在制备治疗对Tie-2激酶活性的调节有响应的疾病的药物中的用途 |
| CA2606068C (en) | 2005-05-02 | 2013-10-29 | Novartis Ag | Pyrimidylaminobenzamide derivatives for hypereosinophilic syndrome |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| ES2549327T3 (es) * | 2005-12-06 | 2015-10-27 | Novartis Ag | Derivados de pirimidilaminobenzamida para el tratamiento de la neurofibromatosis |
| EP1976495A2 (en) * | 2006-01-06 | 2008-10-08 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| WO2008021781A1 (en) | 2006-08-07 | 2008-02-21 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| CA2669311C (en) | 2006-11-13 | 2011-09-20 | Pfizer Products Inc. | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof |
| SI2497470T1 (sl) | 2006-11-22 | 2016-02-29 | Incyte Holdings Corporation | Imidazotriazini in imidazopirimidini kot inhibitorji kinaz |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| WO2008151183A1 (en) | 2007-06-04 | 2008-12-11 | Avila Therapeutics, Inc. | Heterocyclic compounds and uses thereof |
| US8367686B2 (en) | 2007-06-07 | 2013-02-05 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| US9062023B2 (en) | 2007-06-07 | 2015-06-23 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| WO2009036066A1 (en) * | 2007-09-10 | 2009-03-19 | Curis, Inc. | Vegfr inhibitors containing a zinc binding moiety |
| WO2010019540A1 (en) * | 2008-08-13 | 2010-02-18 | Novartis Ag | Treatment of pulmonary arterial hypertension |
| WO2009143211A2 (en) | 2008-05-21 | 2009-11-26 | Incyte Corporation | Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same |
| CA2729012A1 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| WO2010036813A1 (en) * | 2008-09-24 | 2010-04-01 | University Of South Florida | Materials and methods for preventing or treating neurodegenerative conditions associated with abeta peptide accumulation |
| US8293897B2 (en) * | 2008-10-14 | 2012-10-23 | Ning Xi | Compounds comprising a spiro-ring and methods of use |
| US8227477B2 (en) | 2008-11-05 | 2012-07-24 | Greta Sterimbaum | Nilotinib HCl crystalline forms |
| WO2010060074A1 (en) * | 2008-11-24 | 2010-05-27 | Teva Pharmaceutical Industries Ltd. | Preparation of nilotinib and intermediates thereof |
| CN102316738A (zh) * | 2009-02-18 | 2012-01-11 | 盛泰萨路申有限公司 | 作为激酶抑制剂的酰胺类 |
| ES2578990T3 (es) * | 2009-03-21 | 2016-08-03 | Sunshine Lake Pharma Co., Ltd. | Derivados de amino éster, sales de los mismos y métodos de uso |
| EP2461673A4 (en) | 2009-08-05 | 2013-08-07 | Intra Cellular Therapies Inc | NEW REGULATOR PROTEINS AND HEMMER |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| US8487096B2 (en) | 2010-02-03 | 2013-07-16 | Incyte Corporation | Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors |
| WO2011118812A1 (ja) * | 2010-03-26 | 2011-09-29 | 国立大学法人北海道大学 | 神経変性疾患治療薬 |
| EP2736904B1 (en) | 2011-07-27 | 2016-03-16 | AB Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
| US9474753B2 (en) | 2012-05-02 | 2016-10-25 | Georgetown University | Treating neural disease with tyrosine kinase inhibitors |
| HRP20181109T1 (hr) * | 2013-12-11 | 2018-11-02 | Biogen Ma Inc. | Spojevi biarila korisni za liječenje ljudskih bolesti u onkologiji, neurologiji i imunologiji |
| JP6668329B2 (ja) | 2015-03-25 | 2020-03-18 | 国立研究開発法人国立長寿医療研究センター | 新規オキサジアゾール誘導体及びこれを含有する医薬 |
| CN105030776A (zh) * | 2015-06-24 | 2015-11-11 | 北京键凯科技有限公司 | Src蛋白抑制剂在制备预防和/治疗阿尔兹海默病药物中的应用 |
| CN106905298A (zh) * | 2015-12-22 | 2017-06-30 | 江苏先声药业有限公司 | 盐酸尼洛替尼杂质的制备方法 |
| US11426406B2 (en) | 2017-02-09 | 2022-08-30 | Georgetown University | Compositions and methods for treating lysosomal storage disorders |
| WO2018207154A1 (en) * | 2017-05-12 | 2018-11-15 | The Hong Kong University Of Science And Technology | Heterocyclic compounds as epha4 inhibitors |
| WO2020056132A1 (en) * | 2018-09-13 | 2020-03-19 | University Of Southern California | Novel fgfr inhibitors and uses thereof |
| WO2020106825A1 (en) | 2018-11-20 | 2020-05-28 | Georgetown University | Compositions and methods for treating neurodegenerative, myodegenerative, and lysosomal storage disorders |
| JP2022523562A (ja) * | 2019-03-05 | 2022-04-25 | ホンイー アンド アソシエイツ エルエルシー | 神経変性疾患および癌の治療のための化合物 |
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| WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| NZ273617A (en) | 1993-10-01 | 1996-11-26 | Ciba Geigy Ag | N-phenyl-2-pyrimidineamine derivatives pharmaceutical compositions |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
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2003
- 2003-10-27 GB GBGB0325031.3A patent/GB0325031D0/en not_active Ceased
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2004
- 2004-10-26 US US10/576,175 patent/US7687512B2/en not_active Expired - Fee Related
- 2004-10-26 WO PCT/EP2004/012080 patent/WO2005039586A1/en not_active Ceased
- 2004-10-26 JP JP2006536068A patent/JP4827737B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
Also Published As
| Publication number | Publication date |
|---|---|
| US7687512B2 (en) | 2010-03-30 |
| GB0325031D0 (en) | 2003-12-03 |
| WO2005039586A1 (en) | 2005-05-06 |
| JP2007509106A (ja) | 2007-04-12 |
| US20070129389A1 (en) | 2007-06-07 |
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