JP4795237B2 - Ｎ−置換ピラゾリル−アミジル−ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 - Google Patents

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Publication number

JP4795237B2

JP4795237B2 JP2006523954A JP2006523954A JP4795237B2 JP 4795237 B2 JP4795237 B2 JP 4795237B2 JP 2006523954 A JP2006523954 A JP 2006523954A JP 2006523954 A JP2006523954 A JP 2006523954A JP 4795237 B2 JP4795237 B2 JP 4795237B2

Authority

JP

Japan

Prior art keywords

alkyl

benzimidazole

acid

carboxamide

pharmaceutically acceptable

Prior art date

2003-08-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• -1 N-substituted pyrazolyl-amidyl-benzimidazolyl Chemical group 0.000 title claims description 22
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• 239000003112 inhibitor Substances 0.000 title description 13
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• 125000000217 alkyl group Chemical group 0.000 claims description 48
• 150000003839 salts Chemical class 0.000 claims description 36
• 125000000623 heterocyclic group Chemical group 0.000 claims description 16
• 125000004122 cyclic group Chemical group 0.000 claims description 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
• 125000003545 alkoxy group Chemical group 0.000 claims description 8
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 7
• 229910052799 carbon Inorganic materials 0.000 claims description 7
• 125000003342 alkenyl group Chemical group 0.000 claims description 5
• 229910052801 chlorine Inorganic materials 0.000 claims description 5
• 229910052731 fluorine Inorganic materials 0.000 claims description 5
• 229910052736 halogen Inorganic materials 0.000 claims description 5
• 150000002367 halogens Chemical class 0.000 claims description 5
• 229910052739 hydrogen Inorganic materials 0.000 claims description 5
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
• 125000001424 substituent group Chemical group 0.000 claims description 4
• 125000000304 alkynyl group Chemical group 0.000 claims description 3
• UPQTXQWNEOLBOJ-UHFFFAOYSA-N 1-(3-fluorophenyl)-n-(2-methyl-5-phenylpyrazol-3-yl)benzimidazole-5-carboxamide Chemical compound CN1N=C(C=2C=CC=CC=2)C=C1NC(=O)C(C=C1N=C2)=CC=C1N2C1=CC=CC(F)=C1 UPQTXQWNEOLBOJ-UHFFFAOYSA-N 0.000 claims description 2
• 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 2
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