ATE413395T1 - N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n - Google Patents

N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n

Info

Publication number
ATE413395T1
ATE413395T1 AT04781203T AT04781203T ATE413395T1 AT E413395 T1 ATE413395 T1 AT E413395T1 AT 04781203 T AT04781203 T AT 04781203T AT 04781203 T AT04781203 T AT 04781203T AT E413395 T1 ATE413395 T1 AT E413395T1
Authority
AT
Austria
Prior art keywords
amidyl
benzimidazolyl
substituted pyrazolyl
kit inhibitor
inhibitor
Prior art date
Application number
AT04781203T
Other languages
German (de)
English (en)
Inventor
Joshua Bolger
Arlindo Castelhano
Andrew Crew
Radoslaw Laufer
An-Hu Li
Smith Colin Peter Sambrook
Yingchuan Sun
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Application granted granted Critical
Publication of ATE413395T1 publication Critical patent/ATE413395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04781203T 2003-08-21 2004-08-16 N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n ATE413395T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21

Publications (1)

Publication Number Publication Date
ATE413395T1 true ATE413395T1 (de) 2008-11-15

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04781203T ATE413395T1 (de) 2003-08-21 2004-08-16 N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n

Country Status (19)

Country Link
EP (1) EP1664032B1 (cg-RX-API-DMAC7.html)
JP (1) JP4795237B2 (cg-RX-API-DMAC7.html)
KR (1) KR20060115346A (cg-RX-API-DMAC7.html)
CN (1) CN1839130A (cg-RX-API-DMAC7.html)
AP (1) AP2006003553A0 (cg-RX-API-DMAC7.html)
AR (1) AR045389A1 (cg-RX-API-DMAC7.html)
AT (1) ATE413395T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004268948A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0413785A (cg-RX-API-DMAC7.html)
CA (1) CA2536151A1 (cg-RX-API-DMAC7.html)
DE (1) DE602004017623D1 (cg-RX-API-DMAC7.html)
IL (1) IL173616A0 (cg-RX-API-DMAC7.html)
IS (1) IS8320A (cg-RX-API-DMAC7.html)
MX (1) MXPA06002017A (cg-RX-API-DMAC7.html)
NO (1) NO20060665L (cg-RX-API-DMAC7.html)
RU (1) RU2006108791A (cg-RX-API-DMAC7.html)
TW (1) TW200524911A (cg-RX-API-DMAC7.html)
UA (1) UA84712C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005021537A1 (cg-RX-API-DMAC7.html)

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JP6423372B2 (ja) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体
CN105264380B (zh) 2013-05-14 2017-09-05 卫材R&D管理有限公司 用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
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SMT202200367T1 (it) 2014-08-28 2022-11-18 Eisai R&D Man Co Ltd Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso
CA2976325C (en) 2015-02-25 2023-07-04 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
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Also Published As

Publication number Publication date
CA2536151A1 (en) 2005-03-10
AU2004268948A1 (en) 2005-03-10
AP2006003553A0 (en) 2006-04-30
IL173616A0 (en) 2006-07-05
AR045389A1 (es) 2005-10-26
WO2005021537A1 (en) 2005-03-10
IS8320A (is) 2006-02-21
RU2006108791A (ru) 2006-07-27
BRPI0413785A (pt) 2006-11-07
JP2007502820A (ja) 2007-02-15
CN1839130A (zh) 2006-09-27
UA84712C2 (en) 2008-11-25
TW200524911A (en) 2005-08-01
DE602004017623D1 (de) 2008-12-18
EP1664032B1 (en) 2008-11-05
MXPA06002017A (es) 2006-05-31
NO20060665L (no) 2006-05-16
KR20060115346A (ko) 2006-11-08
EP1664032A1 (en) 2006-06-07
JP4795237B2 (ja) 2011-10-19

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