JP4769104B2 - Cosmetics containing carrot extract - Google Patents

Cosmetics containing carrot extract Download PDF

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JP4769104B2
JP4769104B2 JP2006080103A JP2006080103A JP4769104B2 JP 4769104 B2 JP4769104 B2 JP 4769104B2 JP 2006080103 A JP2006080103 A JP 2006080103A JP 2006080103 A JP2006080103 A JP 2006080103A JP 4769104 B2 JP4769104 B2 JP 4769104B2
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hair
hair growth
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JP2007254343A (en
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昌彦 河本
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Naris Cosmetics Co Ltd
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Naris Cosmetics Co Ltd
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本発明は、人参抽出物を含有した化粧料に関し、詳しくは、沖縄県津堅島産の人参抽出物を含有し、皮膚に対しては乾燥肌や肌荒れ等の改善による美肌効果に優れ、一方、頭髪に対しては染毛、育毛、発毛促進効果に優れた化粧料及び染毛剤及び育毛・発毛剤に関する。 The present invention relates to a cosmetic containing a ginseng extract, specifically, contains a ginseng extract from Tsuken Island, Okinawa Prefecture, and has excellent skin beautifying effects by improving dry skin, rough skin, etc. The present invention relates to cosmetics and hair dyes that are excellent in hair dyeing, hair growth, and hair growth promoting effects, and hair growth and hair growth agents.

従来から化粧料等には、各種の植物エキス等が配合されてきた。例えば、皮膚化粧料には肌荒れ防止やシワ改善等を目的として、人参、ヨクイニン、オウゴン等の抽出エキス等が特許文献1及び2に、また、染毛剤には化学合成品が特許文献3に、更に、育毛・発毛剤には養毛効果目的としてヨクイニンやカシュウ等の植物抽出エキスが特許文献4及び5に配合されていることが例示されている。
特開2001−302438号公報 特開2005−53842号公報 特開平5−186319号公報 特開2000−264826号公報 特開2000−327520号公報
Conventionally, various plant extracts and the like have been blended in cosmetics and the like. For example, for skin cosmetics, extract extracts such as carrots, yokuinin, ougon, etc. are disclosed in Patent Documents 1 and 2 for the purpose of preventing rough skin and improving wrinkles. Furthermore, it is exemplified in Patent Documents 4 and 5 that plant extract extracts such as Yokuinin and Kashu are blended in the hair growth / hair growth agent for the purpose of nourishing hair.
JP 2001-302438 A JP 2005-53842 A JP-A-5-186319 JP 2000-264826 A JP 2000-327520 A

ところが、これまでに提供された化粧料には前記に示す各種の植物エキスが適用されているが、顕著な効果を示すものは殆ど無く、また、染毛効果のあるものは皮膚炎を起こす等の刺激が強く、連続して使用することが困難である等の問題が発生していた。 However, the various plant extracts shown above are applied to the cosmetics provided so far, but there are almost no remarkable effects, and those having a hair coloring effect cause dermatitis, etc. There were problems such as strong irritation and difficulty in continuous use.

本発明は、このような実状に鑑みてなされたものであって、皮膚に対しては乾燥感や肌荒れ等の改善による美肌効果に優れ、一方、頭髪に対しては染毛効果、育毛・発毛促進効果に優れ、かつ、長期にわたる使用に十分耐えうる安全性を備えた化粧料、染毛剤及び育毛・発毛剤を提供することを課題とする。 The present invention has been made in view of such a situation, and is excellent in skin beautifying effect by improving dry feeling and rough skin on the skin, while on the other hand, it is effective in hair dyeing, hair growth and development on the hair. It is an object of the present invention to provide a cosmetic, a hair dye, and a hair growth / hair growth agent that is excellent in hair promoting effect and has safety sufficient to withstand long-term use.

本発明者は、前記課題を解決するため鋭意研究を重ねた結果、沖縄県津堅島産人参(以下、ツケンニンジンとする。)から得られた抽出物が皮膚に対する優れた美肌効果を有し、一方で頭髪に対しては優れた染毛効果、優れた育毛・発毛効果を有し、かつ、使用時における高い安全性を有することを見出し、本発明の完成に至った。 As a result of repeated earnest research to solve the above problems, the present inventor has an excellent skin beautifying effect on the skin of an extract obtained from Tsukenjima ginseng (hereinafter referred to as tsukenninjin), Okinawa Prefecture, On the other hand, it has been found that it has excellent hair dyeing effect, excellent hair growth / hair growth effect for hair, and high safety during use, and has completed the present invention.

即ち、本発明は、ツケンニンジンから得られた抽出物、好ましくはツケンニンジンの根茎部を熱水溶媒又は油溶媒を用いて抽出して得られる抽出物を含有させることにより、皮膚に対する優れた美肌効果を有し、一方で頭髪に対しては優れた染毛効果、優れた育毛・発毛効果を有し、かつ、使用時における高い安全性を有する化粧料、染毛剤及び育毛・発毛剤を提供することを可能とした。   That is, the present invention provides an excellent skin to skin by containing an extract obtained from tsukennin carrot, preferably an extract obtained by extracting a rhizome part of tsukennin carrot using a hot water solvent or an oil solvent. Cosmetics, hair dyes and hair growth / hair growth that have an effect, on the other hand, excellent hair coloring effect, excellent hair growth / hair growth effect for hair, and high safety during use It was possible to provide an agent.

本発明のツケンニンジン抽出物配合の化粧料は、肌荒れ等の皮膚状態の改善など美肌効果が格段に優れ、ツケンニンジン抽出物配合の染毛剤は優れた染毛効果を有し、また、ツケンニンジン抽出物配合の発毛・育毛剤は優れた発毛・育毛効果を有することは勿論のこと長期間の連続使用による皮膚障害等も認められず、高い安全性を有する。   The cosmetic composition containing the tsukennin carrot extract of the present invention has an excellent skin beautifying effect such as improvement of the skin condition such as rough skin, and the hair dye composition containing the tsukennin carrot extract has an excellent hair dyeing effect. The hair growth / hair growth agent formulated with carrot extract has not only excellent hair growth / hair growth effect, but also skin damage and the like due to long-term continuous use, and high safety.

本発明に用いることができツケンニンジンの抽出物は、沖縄県津堅島で栽培されるセリ科ニンジン属ニンジン(Daucus carota L.)より得られ、特にTE30品種が好ましい。 An extract of tsuken carrot that can be used in the present invention is obtained from a carrot genus carrot (Daucus carota L.) cultivated in Tsuken Island, Okinawa Prefecture, and TE30 variety is particularly preferable.

本発明に用いることができるツケンニンジンの抽出部位は、ツケンニンジン全草を用いても良いが、根を含む地中部が好ましい。 As for the extraction site of tsukennin carrot that can be used in the present invention, tsukennin carrot whole plant may be used, but the underground part including the root is preferable.

本発明に用いることができるツケンニンジンの抽出方法は、ツケンニンジンを乾燥、或はそのままフレーク状にしたものを溶媒抽出する。また、抽出に用いることができる溶媒は、水、エタノール等のアルコール類、1,3−ブチレングリコールやプロピレングリコール等の多価アルコール類、水を50重量%以上の含有した水溶性有機溶媒、オリーブオイル、スクワラン、トリ(カプリル・カプロン酸)グリセリン等の油性溶媒を用いておこなうことができる。そして、水を50重量%以上の含有した水溶性有機溶媒及びトリ(カプリル・カプロン酸)グリセリンを用いておこなうのが好ましい。
また、抽出の条件は、有効成分が抽出できれば特に制限は無いが、好ましくは、溶媒量は抽出対象物1に対して抽出溶媒1/10〜10倍量(重量%換算)の量を用い、室温〜100℃の温度で、室温では4〜10日間、100℃加温では4〜8時間、それぞれ浸漬させる作業を1回又は2回繰り返し、その後、加温抽出の場合は室温まで放置冷却し、濾過後、ツケンニンジン抽出物とする。
尚、抽出時に加圧することも可能で、その場合には上記常圧条件に比べ少量の抽出溶媒量にて抽出ができ、抽出時間も短縮することが可能である。
In the method for extracting tsukennin carrot that can be used in the present invention, the tsukennin carrot is dried or flaked as it is, and solvent extraction is performed. Solvents that can be used for extraction are water, alcohols such as ethanol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, water-soluble organic solvents containing 50% by weight or more of water, olives It can be carried out using an oily solvent such as oil, squalane, tri (capryl / caproic acid) glycerin and the like. And it is preferable to carry out using the water-soluble organic solvent and tri (capryl caproic acid) glycerin which contained 50 weight% or more of water.
Further, the extraction conditions are not particularly limited as long as the active ingredient can be extracted, but preferably, the amount of the solvent is 1/10 to 10 times the amount of the extraction solvent with respect to the extraction object 1 (weight% conversion), Repeat the work of soaking at room temperature to 100 ° C for 4 to 10 days at room temperature and 4 to 8 hours at 100 ° C for heating, and then let it cool to room temperature for warm extraction. After filtration, the extract is made from tsukenninjin extract.
In addition, it is also possible to pressurize at the time of extraction, and in that case, extraction can be performed with a small amount of extraction solvent compared to the normal pressure condition, and the extraction time can be shortened.

本発明に用いることができるツケンニンジンの抽出物の配合量は、有効であれば特に制限は無いが、化粧料、染毛剤、及び発毛・育毛剤全体に対して0.01〜10.0重量%が好ましく、特に0.1〜5.0重量%が好ましい。また、配合量が0.001重量%未満では効果が十分に発揮されにくい場合があり、20.0重量%以上では、剤形によっては安定性が低下する場合がある。 The amount of tsukennin carrot extract that can be used in the present invention is not particularly limited as long as it is effective, but it is 0.01 to 10% based on the total amount of the cosmetic, the hair dye, and the hair growth / hair growth agent. 0 wt% is preferable, and 0.1 to 5.0 wt% is particularly preferable. Further, if the blending amount is less than 0.001% by weight, the effect may not be sufficiently exerted, and if it is 20.0% by weight or more, the stability may be lowered depending on the dosage form.

本発明の化粧料、染毛剤及び発毛・育毛剤には、前記必須成分の他に必要に応じて通常の化粧料、染毛剤及び発毛・育毛剤に用いられる各種成分を適宜配合可能である。例えば、無機顔料、有機顔料、無機粉体、有機粉体等の粉体類、炭化水素類、ロウ油脂類、エステル類、高級脂肪酸類、高級アルコール類、トリグリセリド類、ラノリン類、ワックス類、動植物油、シリコーン油等の油性成分、陰イオン性、陽イオン性、両性、非イオン性等の界面活性剤類、多価アルコール類、糖類、ビタミン類、高分子、アミノ酸類、清涼剤、酸化防止剤、防腐・抗菌剤、香料、増粘剤、紫外線防御剤、アルコール類、pH調製剤、各種有効成分及び水等を配合することができる。 The cosmetics, hair dyes and hair growth / hair growth agents of the present invention are appropriately blended with various components used in normal cosmetics, hair dyes and hair growth / hair growth agents as needed in addition to the essential components. Is possible. For example, powders such as inorganic pigments, organic pigments, inorganic powders, organic powders, hydrocarbons, waxes and fats, esters, higher fatty acids, higher alcohols, triglycerides, lanolins, waxes, animals and plants Oils, oily components such as silicone oils, anionic, cationic, amphoteric, nonionic surfactants, polyhydric alcohols, sugars, vitamins, polymers, amino acids, refreshing agents, antioxidants Agents, antiseptic / antibacterial agents, fragrances, thickeners, UV protection agents, alcohols, pH adjusters, various active ingredients, water and the like can be blended.

以下、実施例を挙げて、本発明を具体的に説明するが、本発明は何ら実施例に限定されるものではない。 EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to an Example at all.

表1に本発明のツケンニンジン抽出物、比較例として兵庫県、佐賀県、高知県及び群馬県の各産地の同種のニンジン抽出物の抽出方法を示す。 Table 1 shows a method for extracting the carrot extract of the same kind in the production areas of Hyogo, Saga, Kochi and Gunma prefectures as comparative examples.

Figure 0004769104
Figure 0004769104

次に、本発明の化粧料、染毛剤及び発毛・育毛剤の効果についての試験結果を示す。 Next, the test result about the effect of the cosmetics, hair dye, and hair growth / hair growth agent of the present invention is shown.

〔美肌効果試験〕
(1)試料
表2に示す処方にて化粧水を調製した。また試験及び評価は下記記載の内容にて行い、その結果を表3に示す。
[Beautiful skin effect test]
(1) Sample A lotion was prepared according to the formulation shown in Table 2. Tests and evaluations were conducted according to the contents described below, and the results are shown in Table 3.

(2)試験方法
i)乾燥肌を有する成人女性60名をそれぞれ10名ずつ無作為に6群に分ける。
i i)各群10名のパネラーの顔面に実施例4、比較例5〜比較例9の化粧水を、それぞれ4週間使用する。
i i i)4週間後の乾燥感の改善状態及び自然増悪の状態について群間比較する。
i v)肌荒れ状態の評価は特開昭63−113358号公報記載の方法(テープストリッピング法)にて評価する。(表3の数値はパネラーの人数)
(2) Test method
i) Randomly divide 60 adult women with dry skin into 6 groups of 10 each.
ii) The skin lotions of Example 4 and Comparative Examples 5 to 9 are used on the faces of 10 panelists in each group for 4 weeks.
iii) Comparison between the groups regarding the state of improvement in dryness and the state of natural exacerbation after 4 weeks.
iv) The rough skin is evaluated by the method (tape stripping method) described in JP-A-63-113358. (The numbers in Table 3 are the number of panelists.)

Figure 0004769104
Figure 0004769104

Figure 0004769104
Figure 0004769104

表3の結果に示されるように、本発明の化粧水は比較例の各化粧水に比べ、乾燥感の改善、肌荒れ改善効果が顕著であり、美肌効果に優れていることが実証された。
つまり、本発明のツケンニンジン抽出物は、他の産地の同種のニンジン抽出物とは明らかに美肌効果に優れていることを証明しており、本発明のツケンニンジン抽出物が特異的に優れた美肌効果を有していることが実証された。
尚、上記評価以外の効果として、本発明の化粧水は使用時における刺激感、皮膚の炎症などの安全面での弊害は全くなく、安全性が極めて高いことが実証された。
As shown in the results of Table 3, the skin lotion of the present invention has a significant improvement in dry feeling and rough skin improvement as compared with the skin lotions of the comparative examples, and was proved to be excellent in skin beautifying effect.
That is, the tsuken carrot extract of the present invention has proved to be clearly superior in skin beautifying effect with the carrot extract of the same kind in other production areas, and the tsuken carrot extract of the present invention was specifically superior. It was proved to have a beautifying skin effect.
As an effect other than the above evaluation, it was demonstrated that the lotion of the present invention has no adverse effects on safety such as irritation and skin irritation during use, and is extremely safe.

〔染毛効果試験〕
(1)試料
表4に示す処方にて染毛ローションを調製した。また、試験及び評価は下記記載の内容にて行い、その結果を表4に示す。
[Hair dyeing effect test]
(1) Sample A hair dyeing lotion was prepared according to the formulation shown in Table 4. Further, tests and evaluations were conducted with the contents described below, and the results are shown in Table 4.

(2)試験方法
i)染毛していない成人女性70名をそれぞれ10名ずつ無作為に7群に分ける。
i i)各群10名のパネラーに実施例5及び実施例6、比較例10〜比較例14の染毛ローションを、それぞれ1週間使用する。
i i i)1週間後の染毛状態について、肉眼外観判定で群間比較する。
(表4の数値はパネラーの人数)
(2) Test method
i) Randomly divide 70 adult women who are not dyed into 7 groups.
ii) The hair dye lotion of Example 5 and Example 6, Comparative Example 10 to Comparative Example 14 is used for 10 weeks for each group of 1 panelist for 1 week.
iii) About the hair dyeing state after one week, it compares between groups by visual appearance determination.
(The numbers in Table 4 are the number of panelists)

Figure 0004769104
Figure 0004769104

表4の結果から明らかなように、本発明の染毛剤は、比較例10〜比較例14と比べて、明らかに染毛効果が優れていることが実証された。
つまり、本発明のツケンニンジン抽出物は、他の産地の同種のニンジン抽出物とは明らかに染毛効果に優れていることを証明しており、本発明のツケンニンジン抽出物が特異的に優れた染毛効果を有していることが実証された。
尚、上記評価以外の効果として、本発明の染毛ローションは使用時における頭皮及び頭髪に対してのトラブル等の弊害は全くなく、安全性が極めて高いことが実証された。
As is clear from the results in Table 4, it was demonstrated that the hair dye of the present invention clearly has a superior hair dyeing effect as compared with Comparative Examples 10 to 14.
That is, the tsuken carrot extract of the present invention has proved to be clearly superior in the hair dyeing effect with the carrot extract of the same kind in other production areas, and the tsuken carrot extract of the present invention is specifically superior. It was proved to have a hair dyeing effect.
As an effect other than the above evaluation, it was demonstrated that the hair dye lotion of the present invention has no harmful effects such as troubles on the scalp and hair during use, and is extremely safe.

〔発毛・育毛効果試験〕
(1)試料
表5に示す処方にてヘアトニックを調製した。また、試験及び評価は下記記載の内容にて行い、その結果を表5に示す。
[Hair growth and hair growth effect test]
(1) Sample A hair tonic was prepared according to the formulation shown in Table 5. Further, tests and evaluations were conducted according to the following contents, and the results are shown in Table 5.

(2)試験方法
i)薄毛症を訴える成人35名をそれぞれ5名ずつ無作為に7群に分ける。
i i)各群5名のパネラーに実施例7及び実施例8、比較例15〜比較例19のヘアトニックをそれぞれ6ヶ月使用する。
i i i)3ヶ月後及び6ヵ月後のうぶ毛、硬毛の増加状態、抜け毛数の減少について、群間比較する。(表5の数値はパネラーの人数)
(2) Test method
i) Randomly divide 35 adults complaining of hirsutism into 7 groups of 5 each.
ii) The hair tonics of Example 7 and Example 8 and Comparative Examples 15 to 19 are used for 5 months for each group of 5 panelists.
iii) Compare between groups for the increase in vellus hair, bristles and decrease in hair loss after 3 and 6 months. (The numbers in Table 5 are the number of panelists.)

Figure 0004769104
Figure 0004769104

表5の結果より明らかなように、本発明の発毛・育毛剤は、うぶ毛を生じたパネラー、硬毛を生じたパネラー何れも増加し、また、抜け毛も減少していることから、発毛・育毛効果が極めて高いことが認めたれた。
つまり、本発明のツケンニンジン抽出物は、他の産地の同種のニンジン抽出物とは明らかに発毛・育毛効果に優れていることを証明しており、本発明のツケンニンジン抽出物が特異的に優れた発毛・育毛効果を有していることが実証された。
尚、上記評価以外の効果として、本発明のトニックは使用時における頭皮及び頭髪に対してのトラブル等の弊害は全くなく、安全性が極めて高いことが実証された。
As is clear from the results in Table 5, the hair growth / hair growth agent of the present invention increased both the panelists that produced vellus hair and the panelers that produced hard hair, and decreased hair loss. It was confirmed that the hair and hair growth effect was extremely high.
In other words, the tsuken carrot extract of the present invention proves to be clearly superior in hair growth and hair growth effect from the same kind of carrot extract of other production areas, and the tsuken carrot extract of the present invention is specific. It has been demonstrated that it has excellent hair growth and hair growth effects.
As an effect other than the above evaluation, it was proved that the tonic of the present invention has no harmful effects such as troubles on the scalp and hair during use, and is extremely safe.

実施例1〜実施例3のツケンニンジン抽出物と比較例1〜比較例4に用いた各県で栽培された同種のニンジン(Daucus carota L.)抽出物の成分にはβ-カロチンの含有量の他、HPLC分析の結果、以下のような差が見られた。
〔HPLC分析条件〕
・HPLC機器:島津製作所製6A
・カラム :島津製作所製CLC−ODS(黄)
・測定条件 :アセトニトリル/リン酸緩衝液=15/85,210nm/5μl
・チャート速度:2mm/分,attenuation 64mvf・s
実施例1(ツケンニンジン抽出物):RT2.7分とRT5.5分に大ピークあり。
兵庫県産ニンジン抽出物 :RT2.7分のみに大ピークあり。
The content of β-carotene in the components of the extract of carrot (Daucus carota L.) of the same kind used in the prefectures used in Examples 1 to 3 and Comparative Examples 1 to 4 In addition, as a result of HPLC analysis, the following differences were observed.
[HPLC analysis conditions]
HPLC instrument: Shimadzu 6A
Column: Shimadzu CLC-ODS (yellow)
Measurement conditions: acetonitrile / phosphate buffer solution = 15/85, 210 nm / 5 μl
・ Chart speed: 2mm / min, attenuation 64mvf ・ s
Example 1 (Tsunen ginseng extract): Large peaks at RT 2.7 minutes and RT 5.5 minutes.
Hyogo prefecture carrot extract: Large peak only at RT 2.7 min.

以下に処方例を示すが、本発明はこれに限定されない。 Although a formulation example is shown below, this invention is not limited to this.

Figure 0004769104
Figure 0004769104

Figure 0004769104
Figure 0004769104

Figure 0004769104
Figure 0004769104

本発明のツケンニンジン抽出物を配合した化粧料、染毛剤及び発毛・育毛剤は、美肌効果に優れ、染毛効果や発毛・育毛効果に優れ、しかも高い安全性を有するため、化粧料を始め種々の頭髪剤や染毛剤及び発毛・育毛剤に広く応用が期待できる。 Cosmetics, hair dyes and hair growth / hair growth agents formulated with tsukennin carrot extract of the present invention have excellent skin beautifying effects, excellent hair dyeing effects, hair growth / hair growth effects, and high safety. It can be expected to be widely applied to various hair preparations, hair dyes, hair growth / hair growth agents, and other hair preparations.

Claims (3)

沖縄県津堅島産人参の抽出物からなる染毛剤。 A hair dye consisting of water extract from ginseng from Tsukenjima, Okinawa. 沖縄県津堅島産人参の抽出物からなる発毛剤。 A hair growth agent made of water extract from ginseng from Tsukenjima, Okinawa. 沖縄県津堅島産人参の抽出物からなる育毛剤。 A hair restorer made from water extract of ginseng from Tsukenjima, Okinawa.
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