JP4703186B2 - 封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法 - Google Patents

封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法 Download PDF

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JP4703186B2
JP4703186B2 JP2004526684A JP2004526684A JP4703186B2 JP 4703186 B2 JP4703186 B2 JP 4703186B2 JP 2004526684 A JP2004526684 A JP 2004526684A JP 2004526684 A JP2004526684 A JP 2004526684A JP 4703186 B2 JP4703186 B2 JP 4703186B2
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csf
inclusion bodies
concentration
protein
fermentation
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JP2006502708A (ja
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メナート，ビクトル
ガベルチポレカル，ブラドカ
イエブセバル，シモナ
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レツク・フアーマシユーテイカルズ・デー・デー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004526684A 2002-07-31 2003-06-11 封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法 Expired - Fee Related JP4703186B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SIP-200200187 2002-07-31
SI200200187A SI21273A (sl) 2002-07-31 2002-07-31 Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
PCT/EP2003/006134 WO2004015124A1 (en) 2002-07-31 2003-06-11 Process for the production of a heterologous protein

Related Child Applications (1)

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JP2010254743A Division JP2011078421A (ja) 2002-07-31 2010-11-15 封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法

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JP2006502708A JP2006502708A (ja) 2006-01-26
JP4703186B2 true JP4703186B2 (ja) 2011-06-15

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JP2004526684A Expired - Fee Related JP4703186B2 (ja) 2002-07-31 2003-06-11 封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法
JP2010254743A Withdrawn JP2011078421A (ja) 2002-07-31 2010-11-15 封入体における高い量の正しく折りたたまれた異種タンパク質の生産方法

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Country Status (9)

Country Link
US (1) US20050283000A1 (enExample)
EP (1) EP1527188B1 (enExample)
JP (2) JP4703186B2 (enExample)
AR (1) AR040719A1 (enExample)
AT (1) ATE456665T1 (enExample)
AU (1) AU2003250347A1 (enExample)
DE (1) DE60331149D1 (enExample)
SI (2) SI21273A (enExample)
WO (1) WO2004015124A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21639A (sl) * 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine
EP1939212A1 (en) * 2006-12-20 2008-07-02 LEK Pharmaceuticals D.D. Organic compounds
WO2008096370A2 (en) * 2007-02-05 2008-08-14 Natco Pharma Limited An efficient and novel purification method of recombinant hg-csf
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
BRPI0815975B8 (pt) 2007-08-27 2021-05-25 Biogenerix Ag preparação aquosa, recipiente farmacêutico, processo para preparar uma preparação aquosa, e, uso de uma preparação aquosa
US20090294362A1 (en) * 2008-05-30 2009-12-03 Persson Jonas Par Stationary phase for hydrophilic interaction chromatography
WO2011109556A2 (en) * 2010-03-04 2011-09-09 Pfenex Inc. Method for producing soluble recombinant interferon protein without denaturing
WO2011123570A2 (en) 2010-04-01 2011-10-06 Pfenex Inc. Methods for g-csf production in a pseudomonas host cell
JP5836621B2 (ja) 2011-03-31 2015-12-24 株式会社マキタ 動力工具
HUP1200171A1 (hu) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Módszerek polipeptidek elõállítására
HUP1200172A2 (en) * 2012-03-19 2013-10-28 Richter Gedeon Nyrt Methods for refolding g-csf from inclusion bodies
US10065987B2 (en) 2013-02-12 2018-09-04 Bristol-Myers Squibb Company High pH protein refolding methods
WO2014126871A1 (en) 2013-02-12 2014-08-21 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
EP3062889A2 (en) * 2013-11-01 2016-09-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
CN104152515B (zh) * 2014-08-14 2019-12-31 江苏奥赛康药业有限公司 一种制备重组人粒细胞集落刺激因子的培养基及发酵方法
JP2020080727A (ja) * 2018-11-26 2020-06-04 Ｓｐｉｂｅｒ株式会社 目的タンパク質の製造方法
JP2023530095A (ja) * 2020-06-09 2023-07-13 アイコサバックス， インコーポレイテッド ウイルス様粒子を作製する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPH0618778B2 (ja) * 1985-10-04 1994-03-16 中外製薬株式会社 白血球減少症治療剤
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
DE4037196A1 (de) * 1990-11-22 1992-05-27 Boehringer Mannheim Gmbh Verfahren zur reaktivierung von denaturiertem protein
EP0832220A1 (en) * 1995-06-07 1998-04-01 Amgen Inc. Ob protein compositions and method
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
CN1154723C (zh) * 1996-12-27 2004-06-23 日本烟草产业株式会社 花器特异性基因及其启动子序列
US20020052026A1 (en) * 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6677139B1 (en) * 1999-12-23 2004-01-13 Genecor International, Inc. Methods for production of proteins in host cells
WO2003102013A2 (en) * 2001-02-23 2003-12-11 Gonzalez-Villasenor Lucia Iren Methods and compositions for production of recombinant peptides
SI21102A (sl) * 2001-12-19 2003-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika

Also Published As

Publication number Publication date
JP2011078421A (ja) 2011-04-21
AR040719A1 (es) 2005-04-20
AU2003250347A1 (en) 2004-02-25
JP2006502708A (ja) 2006-01-26
EP1527188A1 (en) 2005-05-04
WO2004015124A1 (en) 2004-02-19
SI1527188T1 (sl) 2010-05-31
EP1527188B1 (en) 2010-01-27
DE60331149D1 (de) 2010-03-18
SI21273A (sl) 2004-02-29
US20050283000A1 (en) 2005-12-22
ATE456665T1 (de) 2010-02-15

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