JP4700614B2 - ５−ｈｔ１ｆアゴニストとしての置換された２−カルボニルアミノ−６−ピペリジンアミノピリジンおよび置換された１−カルボニルアミノ−３−ピペリジンアミノベンゼン - Google Patents

５−ｈｔ１ｆアゴニストとしての置換された２−カルボニルアミノ−６−ピペリジンアミノピリジンおよび置換された１−カルボニルアミノ−３−ピペリジンアミノベンゼン Download PDF

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JP4700614B2
JP4700614B2 JP2006526084A JP2006526084A JP4700614B2 JP 4700614 B2 JP4700614 B2 JP 4700614B2 JP 2006526084 A JP2006526084 A JP 2006526084A JP 2006526084 A JP2006526084 A JP 2006526084A JP 4700614 B2 JP4700614 B2 JP 4700614B2
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substituted
mmol
methyl
fluoro
phenyl
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JP2007505105A5 (enExample
JP2007505105A (ja
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マリア−ヘスス・ブランコ−ピリャド
マイケル・フィリップ・コーエン
サンドラ・アン・フィラ
ケビン・ジョン・ハジアック
ダニエル・ティモシー・コールマン
ダナ・レイ・ベネッシュ
フランツ・ビクター
ヤオ−チャン・シュ
バイ−ピン・イン
ディアナ・ピアット・ザッカール
デイ・チャン
ブライアン・マイケル・マテス
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イーライ リリー アンド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006526084A 2003-09-12 2004-09-03 ５−ｈｔ１ｆアゴニストとしての置換された２−カルボニルアミノ−６−ピペリジンアミノピリジンおよび置換された１−カルボニルアミノ−３−ピペリジンアミノベンゼン Expired - Fee Related JP4700614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50278003P 2003-09-12 2003-09-12
US60/502,780 2003-09-12
PCT/US2004/025607 WO2005035499A1 (en) 2003-09-12 2004-09-03 Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists

Publications (3)

Publication Number Publication Date
JP2007505105A JP2007505105A (ja) 2007-03-08
JP2007505105A5 JP2007505105A5 (enExample) 2010-05-13
JP4700614B2 true JP4700614B2 (ja) 2011-06-15

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JP2006526084A Expired - Fee Related JP4700614B2 (ja) 2003-09-12 2004-09-03 ５−ｈｔ１ｆアゴニストとしての置換された２−カルボニルアミノ−６−ピペリジンアミノピリジンおよび置換された１−カルボニルアミノ−３−ピペリジンアミノベンゼン

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US (3) US7291632B2 (enExample)
EP (1) EP1663971B1 (enExample)
JP (1) JP4700614B2 (enExample)
KR (1) KR100777875B1 (enExample)
CN (1) CN1849307B (enExample)
AR (1) AR045619A1 (enExample)
AT (1) ATE538093T1 (enExample)
AU (1) AU2004280320B2 (enExample)
BR (1) BRPI0414241A (enExample)
CA (1) CA2537936C (enExample)
CR (1) CR8275A (enExample)
CY (1) CY1112475T1 (enExample)
DK (1) DK1663971T3 (enExample)
EA (1) EA011274B1 (enExample)
EC (1) ECSP066415A (enExample)
ES (1) ES2379665T3 (enExample)
IL (1) IL173521A (enExample)
MA (1) MA28212A1 (enExample)
MX (1) MXPA06002767A (enExample)
MY (1) MY144623A (enExample)
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NZ (1) NZ545049A (enExample)
PE (1) PE20050350A1 (enExample)
PL (1) PL1663971T3 (enExample)
PT (1) PT1663971E (enExample)
SI (1) SI1663971T1 (enExample)
TW (1) TWI340740B (enExample)
UA (1) UA82711C2 (enExample)
WO (1) WO2005035499A1 (enExample)
ZA (1) ZA200602072B (enExample)

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TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
UA82711C2 (en) * 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
DE102005055892A1 (de) * 2005-11-22 2007-05-24 Henkel Kgaa Neue Kupplerkomponenten
JP5727457B2 (ja) 2009-04-02 2015-06-03 コルーシッド ファーマシューティカルズ， インコーポレイテッド ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物
WO2011030537A1 (ja) * 2009-09-08 2011-03-17 杏林製薬株式会社 ４－（５－メチルピリジン－２－イルアミノ）ピペリジン－１－カルボン酸誘導体の製造方法
US8697876B2 (en) 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
EP3027590A1 (en) * 2013-07-31 2016-06-08 Minoryx Therapeutics S.L. Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof
CN109596521A (zh) * 2018-02-11 2019-04-09 中国科学院海洋研究所 磷钼蓝分光光度法中还原剂的保存方法
US11858910B2 (en) 2018-08-24 2024-01-02 Sunshine Lake Pharma Co., Ltd. Pyridinylmethylenepiperidine derivatives and uses thereof
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
AR119319A1 (es) 2019-07-09 2021-12-09 Lilly Co Eli Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida
CN110845402B (zh) * 2019-11-22 2023-05-09 广东东阳光药业有限公司 吡啶亚甲基哌嗪衍生物及其用途
CN111004214B (zh) * 2019-11-22 2021-06-08 广东东阳光药业有限公司 吡啶酰基哌啶衍生物及其用途
WO2021097781A1 (zh) * 2019-11-22 2021-05-27 广东东阳光药业有限公司 吡啶亚甲基哌啶衍生物及其用途
CN113045540B (zh) * 2019-12-27 2024-02-13 上海天慈国际药业有限公司 一种拉司米地坦的制备方法
WO2026005536A1 (ko) * 2024-06-28 2026-01-02 주식회사 대웅제약 신규한 화합물, 및 이를 포함하는 암 또는 자가 면역 질환의 예방 또는 치료용 약학적 조성물

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US7803813B2 (en) 2010-09-28
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