JP4691225B2 - グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体 - Google Patents

グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体 Download PDF

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JP4691225B2
JP4691225B2 JP50463399A JP50463399A JP4691225B2 JP 4691225 B2 JP4691225 B2 JP 4691225B2 JP 50463399 A JP50463399 A JP 50463399A JP 50463399 A JP50463399 A JP 50463399A JP 4691225 B2 JP4691225 B2 JP 4691225B2
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humanized antibody
sequence type
antibody
antigen
binding fragment
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JP2002503966A5 (enExample
JP2002503966A (ja
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フィッシャー，ジェラルド，ダブリュ．
シュマン，リチャード，エフ．
ウォン，ヒン
スティンソン，ジェフリー，エル．
Original Assignee
ザ ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP50463399A 1997-06-16 1998-06-16 グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体 Expired - Fee Related JP4691225B2 (ja)

Applications Claiming Priority (3)

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US4987197P 1997-06-16 1997-06-16
US60/049,871 1997-06-16
PCT/US1998/012402 WO1998057994A2 (en) 1997-06-16 1998-06-16 Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

Related Child Applications (1)

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JP2010202662A Division JP2011026327A (ja) 1997-06-16 2010-09-10 グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体

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JP2002503966A JP2002503966A (ja) 2002-02-05
JP2002503966A5 JP2002503966A5 (enExample) 2005-12-22
JP4691225B2 true JP4691225B2 (ja) 2011-06-01

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JP50463399A Expired - Fee Related JP4691225B2 (ja) 1997-06-16 1998-06-16 グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体
JP2010202662A Pending JP2011026327A (ja) 1997-06-16 2010-09-10 グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体

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US (5) US6610293B1 (enExample)
EP (2) EP2357198A1 (enExample)
JP (2) JP4691225B2 (enExample)
AT (1) ATE497977T1 (enExample)
AU (1) AU8144098A (enExample)
CA (1) CA2293732A1 (enExample)
DE (1) DE69842129D1 (enExample)
DK (1) DK0986577T3 (enExample)
ES (1) ES2363689T3 (enExample)
WO (1) WO1998057994A2 (enExample)

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US20100221822A1 (en) 2010-09-02
EP0986577A2 (en) 2000-03-22
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US20040013673A1 (en) 2004-01-22
US20060002939A1 (en) 2006-01-05
US20020082395A1 (en) 2002-06-27
US8372958B2 (en) 2013-02-12
WO1998057994A3 (en) 1999-03-25
AU8144098A (en) 1999-01-04
ES2363689T3 (es) 2011-08-11
US6610293B1 (en) 2003-08-26
JP2011026327A (ja) 2011-02-10
DE69842129D1 (de) 2011-03-24
US7884198B2 (en) 2011-02-08
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US6939543B2 (en) 2005-09-06
US7511122B2 (en) 2009-03-31

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