JP4662708B2 - エクソゾームにタンパク質を標的化する方法および組成物 - Google Patents
エクソゾームにタンパク質を標的化する方法および組成物 Download PDFInfo
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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US7704964B2 (en) | 2001-08-17 | 2010-04-27 | Exothera L.L.C. | Methods and compounds for the targeting of protein to exosomes |
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US7914792B2 (en) * | 2003-02-14 | 2011-03-29 | Exothera L.L.C. | Methods and compounds for raising antibodies and for screening antibody repertoires |
US7771956B2 (en) * | 2003-06-30 | 2010-08-10 | Brigham & Women's Hospital, Inc. | Method for detecting the presence of a phospholipid |
WO2005037229A2 (fr) * | 2003-10-17 | 2005-04-28 | Emory University | Procedes et compositions conçus pour moduler l'adherence des gametes |
US9321822B2 (en) * | 2005-05-13 | 2016-04-26 | The Feinstein Institute For Medical Research | Milk fat globule epidermal growth factor—factor VIII and sepsis |
CN1322115C (zh) * | 2005-07-06 | 2007-06-20 | 清华大学 | 载有外源配体分子的胞外体及其制备方法与应用 |
US8288172B2 (en) * | 2006-03-09 | 2012-10-16 | Aethlon Medical, Inc. | Extracorporeal removal of microvesicular particles |
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EP2117305A4 (fr) * | 2007-01-26 | 2011-03-30 | Univ Louisville Res Found | Modification de composants à base d' exosome utilisés comme vaccin |
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FR2928926B1 (fr) * | 2008-03-18 | 2015-08-21 | Centre Nat Rech Scient | Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes |
EP2358912B1 (fr) * | 2008-10-30 | 2016-10-12 | Caris Life Sciences Switzerland Holdings GmbH | Procédés d'évaluation de motifs arn |
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JP5713325B2 (ja) | 2009-04-17 | 2015-05-07 | アイシス イノヴェイション リミテッド | 遺伝物質の送達用の組成物 |
FR2950350B1 (fr) * | 2009-09-24 | 2013-12-13 | Centre Nat Rech Scient | Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations |
WO2011097480A1 (fr) * | 2010-02-05 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | Compositions exosomales et procédés pour le traitement de maladies |
KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
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US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9816998B2 (en) | 2011-04-01 | 2017-11-14 | Cornell University | Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers |
ITRM20110403A1 (it) | 2011-07-28 | 2013-01-29 | Ospedale Pediatrico Bambino Gesu | Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori. |
KR20130032646A (ko) * | 2011-09-23 | 2013-04-02 | 삼성전자주식회사 | 막단백질 및 광발생 단백질이 결합된 융합단백질을 포함하는 재조합 엑소좀을 이용한 엑소좀 수득율을 측정하는 방법 |
GB201121070D0 (en) * | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
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US5972337A (en) * | 1990-11-01 | 1999-10-26 | Cancer Research Fund Of Contra Costa | 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein |
US5455031A (en) | 1990-11-01 | 1995-10-03 | Cancer Research Fund Of Contra Costa | Polypeptide with 46 Kdalton HMFG differentiation antigen binding specificity, composition, kit and diagnostic method |
IT1264516B1 (it) | 1993-05-31 | 1996-09-24 | Biotop Sas Di Rita Cassarin | Cellule dendritiche immortalizzate |
AU6632496A (en) | 1995-08-03 | 1997-03-05 | Rijksuniversiteit Te Leiden | Cell derived antigen presenting vesicles |
US5834015A (en) | 1996-09-11 | 1998-11-10 | Albany Medical College | Protein-lipid vesicles and autogenous vaccine comprising the same |
FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
FR2785543B1 (fr) | 1998-11-05 | 2003-02-28 | Inst Nat Sante Rech Med | Exosomes modifies et utilisations |
EP1004664A1 (fr) * | 1998-11-24 | 2000-05-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compositions et procédés utilisant la lactadhérine ou des dérivés de celle-ci |
FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
US20040241176A1 (en) | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
US6410271B1 (en) | 2000-06-23 | 2002-06-25 | Genetastix Corporation | Generation of highly diverse library of expression vectors via homologous recombination in yeast |
CA2431212A1 (fr) | 2000-12-27 | 2002-07-25 | Richard T. Wyatt | Proteoliposomes immunogenes et applications de ceux-ci |
US7704964B2 (en) | 2001-08-17 | 2010-04-27 | Exothera L.L.C. | Methods and compounds for the targeting of protein to exosomes |
EP1483372A2 (fr) | 2002-03-14 | 2004-12-08 | Anosys, Inc. | Vesicules derivees de lymphocytes t, production et utilisations |
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2002
- 2002-08-14 US US10/485,360 patent/US7704964B2/en not_active Expired - Fee Related
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- 2002-08-14 JP JP2003521831A patent/JP4662708B2/ja not_active Expired - Fee Related
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- 2002-08-14 CA CA2454756A patent/CA2454756C/fr not_active Expired - Fee Related
- 2002-08-14 WO PCT/EP2002/009108 patent/WO2003016522A2/fr active Application Filing
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Also Published As
Publication number | Publication date |
---|---|
CN1543476A (zh) | 2004-11-03 |
EP1417229A2 (fr) | 2004-05-12 |
WO2003016522A2 (fr) | 2003-02-27 |
JP2005503791A (ja) | 2005-02-10 |
ATE512982T1 (de) | 2011-07-15 |
CA2454756A1 (fr) | 2003-02-27 |
AU2002331244B2 (en) | 2007-02-15 |
CA2454756C (fr) | 2014-02-18 |
CN100590131C (zh) | 2010-02-17 |
US20040197314A1 (en) | 2004-10-07 |
IL160142A0 (en) | 2004-06-20 |
HK1062444A1 (en) | 2004-11-05 |
WO2003016522A3 (fr) | 2003-08-28 |
EP1417229B1 (fr) | 2011-06-15 |
US7704964B2 (en) | 2010-04-27 |
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