JP4656299B2 - 歯磨剤組成物及びε−アミノカプロン酸及び/又はトラネキサム酸含有歯磨剤組成物の変色防止方法 - Google Patents
歯磨剤組成物及びε−アミノカプロン酸及び/又はトラネキサム酸含有歯磨剤組成物の変色防止方法 Download PDFInfo
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- JP4656299B2 JP4656299B2 JP2004374623A JP2004374623A JP4656299B2 JP 4656299 B2 JP4656299 B2 JP 4656299B2 JP 2004374623 A JP2004374623 A JP 2004374623A JP 2004374623 A JP2004374623 A JP 2004374623A JP 4656299 B2 JP4656299 B2 JP 4656299B2
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- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229940057867 methyl lactate Drugs 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229930007459 p-menth-8-en-3-one Natural products 0.000 description 1
- 229940070802 palmitoyl glutamate Drugs 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
なお、本発明においては、上記した組成中の直接還元糖の含有量が上記範囲内であれば、上記ソルビット以外に、必要に応じてその他の糖アルコール、例えばマルチット、ガラクチトール、リボシトール等を添加してもよい。
界面活性剤の配合量は、組成物全体の0.1〜10質量%、特に0.5〜5質量%が好ましい。
表1に示すソルビットを使用し、表2,3に示す組成の歯磨剤組成物を常法により調製し、口径8mmのラミネートチューブに充填した。得られた歯磨剤組成物の(1)分散性、(2)耐乾燥性、(3)液分離、(4)変色について以下の方法により評価した。結果を表2,3に併記する。
専門パネラー10人を用いた官能試験により評価した。歯ブラシ上に約1.5cmの試験歯磨剤組成物を乗せ、通常歯を磨く方法で使用してもらった。使用中の口腔内での歯磨剤組成物の分散性について以下の基準で評価した。
4点:分散性がかなり良い。
3点:分散性が良い。
2点;分散性が悪い。
1点:分散性がかなり悪い。
◎:口腔内での分散性が3.0点以上〜4.0点以下
○:口腔内での分散性が2.5点以上〜3.0点未満
△:口腔内での分散性が2.0点以上〜2.5点未満
×:口腔内での分散性が2.0点未満
歯磨剤組成物を充填したラミネートチューブのふたを開け、50℃恒温槽で24時間保管したのち、歯磨剤組成物を15cm紙に押し出して目視し、下記基準により乾燥による固化を評価した。
◎:固化していない。
○:わずかに口元部分の乾燥が認められる(口元から1cmまでの範囲)。
△:口元から1cmを超えて2cmまでの範囲で乾燥し、固化している。
×:口元から2cmを超えて乾燥し、固化している。
ラミネートチューブに充填した歯磨剤組成物を40℃恒温槽で3ヵ月間保管したのち、歯磨剤組成物を15cm紙に押し出して目視し、下記基準により評価した。
◎:液分離が無く、紙へのしみだしが無い。
○:口元部の液分離がわずかにあり、紙へのしみだしが1.0cm2までの範囲で認め
られる。
△:口元部の液分離があり、紙へのしみだしが1.0cm2を超えて2.0cm2までの
範囲で認められる、あるいは紙の裏面から見て練りにそってしみだしが認められる
。
×:チューブから歯磨剤組成物を押し出した時、分離液がチューブ口元からたれだす程
度に激しく認められる。
ラミネートチューブに充填した歯磨剤組成物を恒温槽で3ヶ月間保管したのち、紙に押し出して目視し、−5℃恒温槽で3ヶ月間保管した歯磨剤組成物を対照品として比較し、下記基準により官能評価した。
◎:対照品と50℃、3ヶ月保存品とを比べて、色の変化がない。
○:対照品と50℃、3ヶ月保存品とを比べて、色の変化がほとんどない。
△:対照品と50℃、3ヶ月保存後とを比べて、色の変化がややある。
×:対照品の50℃、3ヶ月保存後とを比べて、色の変化がある。
*1:直接還元糖含量:0.014質量%
*2:直接還元糖含量:0.020質量%
*3:直接還元糖含量:0.083質量%
(A)ε−アミノカプロン酸:第一化学薬品(株)製、
トラネキサム酸:第一化学薬品(株)製
(B)ソルビットA〜C(純分70%):表中の配合量、及び直接還元糖含量は純分換算した値である。
・香料については、表4に示す香料A〜香料Iを作成し、配合した。
・pHは、pHメーター(METTLER TOLEDO MP220 pH Meter)を用い、電極はMETTLER TOLEDO InLab pII複合電極を用いで、25℃における3分後のpHを測定した。
Claims (2)
- (A)ε−アミノカプロン酸及び/又はトラネキサム酸を0.01〜0.3質量%、(B)直接還元糖含量が0.030質量%未満のソルビットを20〜40質量%、(C)水を10〜50質量%配合し、組成物中の直接還元糖の含有量を0〜0.0060質量%未満とし、かつ25℃における製剤pHを6.0〜8.0としたことを特徴とする歯磨剤組成物。
- (A)ε−アミノカプロン酸及び/又はトラネキサム酸を0.01〜0.3質量%、(B)直接還元糖含量が0.030質量%未満のソルビットを20〜40質量%、(C)水を10〜50質量%含有し、組成物中の直接還元糖の含有量を0〜0.0060質量%未満とし、25℃における製剤pHを6.0〜8.0として、ε−アミノカプロン酸及び/又はトラネキサム酸含有歯磨剤組成物の変色を防止する方法。
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Cited By (1)
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KR20190076829A (ko) | 2017-12-22 | 2019-07-02 | 라이온 가부시키가이샤 | 구강용 조성물 및 그 변색 억제 방법 |
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EP2695605B1 (en) | 2012-08-07 | 2017-05-03 | Parapharm Development Ltd. | Tranexamic acid composition |
JP6456582B2 (ja) * | 2012-09-24 | 2019-01-23 | 共栄化学工業株式会社 | 化粧料用組成物 |
JP6370094B2 (ja) * | 2013-05-08 | 2018-08-08 | 第一三共ヘルスケア株式会社 | 肌の黄ばみを抑制するための組成物 |
WO2016002787A1 (ja) * | 2014-06-30 | 2016-01-07 | ロート製薬株式会社 | 外用剤 |
JP6615007B2 (ja) * | 2016-03-03 | 2019-12-04 | ライオン株式会社 | 口腔用組成物 |
CN108969413A (zh) * | 2017-06-05 | 2018-12-11 | 狮王株式会社 | 口腔用组合物 |
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JP2785298B2 (ja) * | 1989-02-10 | 1998-08-13 | ライオン株式会社 | 口腔用組成物 |
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KR20190076829A (ko) | 2017-12-22 | 2019-07-02 | 라이온 가부시키가이샤 | 구강용 조성물 및 그 변색 억제 방법 |
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