JP4624564B2 - 過酸化によるヒト臓器への損傷に対して保護作用を有する水中油型エマルジョン、その製造及び使用 - Google Patents
過酸化によるヒト臓器への損傷に対して保護作用を有する水中油型エマルジョン、その製造及び使用 Download PDFInfo
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 150000003612 tocotrienol derivatives Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 150000003772 α-tocopherols Chemical class 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859045A DE19859045A1 (de) | 1998-12-21 | 1998-12-21 | Emulsion vom Typ Öl in Wasser mit Schutzwirkung gegen Peroxidationsschäden an menschlichen Organen, deren Herstellung und Verwendung |
| DE19859045.8 | 1998-12-21 | ||
| PCT/EP1999/010106 WO2000037108A1 (de) | 1998-12-21 | 1999-12-18 | Emulsion vom typ öl in wasser mit schutzwirkung gegen peroxidationsschäden an menschlichen organen, deren herstellung und verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002532564A JP2002532564A (ja) | 2002-10-02 |
| JP2002532564A5 JP2002532564A5 (enExample) | 2010-10-28 |
| JP4624564B2 true JP4624564B2 (ja) | 2011-02-02 |
Family
ID=7891978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000589218A Expired - Fee Related JP4624564B2 (ja) | 1998-12-21 | 1999-12-18 | 過酸化によるヒト臓器への損傷に対して保護作用を有する水中油型エマルジョン、その製造及び使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6676956B1 (enExample) |
| EP (1) | EP1140195B1 (enExample) |
| JP (1) | JP4624564B2 (enExample) |
| CN (1) | CN1154511C (enExample) |
| AT (1) | ATE235254T1 (enExample) |
| DE (2) | DE19859045A1 (enExample) |
| DK (1) | DK1140195T3 (enExample) |
| ES (1) | ES2192098T3 (enExample) |
| PT (1) | PT1140195E (enExample) |
| WO (1) | WO2000037108A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080193393A1 (en) * | 2004-09-24 | 2008-08-14 | Lipo Chemicals Inc. | Delivery System for Topically Applied Compounds |
| CN100525753C (zh) * | 2005-11-15 | 2009-08-12 | 董英杰 | 辅酶q10亚微乳注射液及制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4950124A (enExample) * | 1972-09-27 | 1974-05-15 | ||
| JPS57163313A (en) * | 1981-03-31 | 1982-10-07 | Nippon Shinyaku Co Ltd | Vitamin e pharmaceutical and its preparation |
| JPS58162517A (ja) * | 1982-03-19 | 1983-09-27 | Green Cross Corp:The | 脂溶性ビタミン含有脂肪乳剤 |
| IT1191608B (it) * | 1985-02-01 | 1988-03-23 | Zambon Spa | Composizione farmaceutica e forme farmaceutiche che la contengono |
| US4678808A (en) * | 1985-10-15 | 1987-07-07 | Baxter Travenol Laboratories, Inc. | Rapid acting intravenous emulsions of omega-3 fatty acid esters |
| JPH0262829A (ja) * | 1988-05-18 | 1990-03-02 | Nippon Kayaku Co Ltd | 虚血に基づく傷害の予防及び治療剤 |
| US5693337A (en) * | 1994-07-13 | 1997-12-02 | Wakamoto Pharmaceutical Co., Ltd. | Stable lipid emulsion |
| GB9514878D0 (en) | 1995-07-20 | 1995-09-20 | Danbiosyst Uk | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
| DE19758157A1 (de) * | 1997-03-27 | 1998-10-01 | Sueddeutsche Kalkstickstoff | Homogene, Glycerophospholipide und polare oder lipophile Substanzen enthaltende, wasserfreie Formulierungen und Verfahren zu deren Herstellung |
| CA2330610A1 (en) * | 1998-05-07 | 1999-11-11 | Corixa Corporation | Adjuvant composition and methods for its use |
-
1998
- 1998-12-21 DE DE19859045A patent/DE19859045A1/de not_active Withdrawn
-
1999
- 1999-12-18 PT PT99964607T patent/PT1140195E/pt unknown
- 1999-12-18 AT AT99964607T patent/ATE235254T1/de active
- 1999-12-18 US US09/868,789 patent/US6676956B1/en not_active Expired - Lifetime
- 1999-12-18 DE DE59904788T patent/DE59904788D1/de not_active Expired - Lifetime
- 1999-12-18 CN CNB998147478A patent/CN1154511C/zh not_active Expired - Lifetime
- 1999-12-18 EP EP99964607A patent/EP1140195B1/de not_active Expired - Lifetime
- 1999-12-18 DK DK99964607T patent/DK1140195T3/da active
- 1999-12-18 WO PCT/EP1999/010106 patent/WO2000037108A1/de not_active Ceased
- 1999-12-18 JP JP2000589218A patent/JP4624564B2/ja not_active Expired - Fee Related
- 1999-12-18 ES ES99964607T patent/ES2192098T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002532564A (ja) | 2002-10-02 |
| US6676956B1 (en) | 2004-01-13 |
| CN1154511C (zh) | 2004-06-23 |
| EP1140195B1 (de) | 2003-03-26 |
| ATE235254T1 (de) | 2003-04-15 |
| ES2192098T3 (es) | 2003-09-16 |
| DE59904788D1 (de) | 2003-04-30 |
| HK1037527A1 (en) | 2002-02-15 |
| DE19859045A1 (de) | 2000-06-29 |
| WO2000037108A1 (de) | 2000-06-29 |
| DK1140195T3 (da) | 2003-06-23 |
| PT1140195E (pt) | 2003-08-29 |
| CN1331606A (zh) | 2002-01-16 |
| EP1140195A1 (de) | 2001-10-10 |
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