JP4623968B2 - 難溶性化合物から水分散性の乾燥粉末を生成するための製法 - Google Patents
難溶性化合物から水分散性の乾燥粉末を生成するための製法 Download PDFInfo
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- 229960002710 levomethadone Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 229960003587 lisuride Drugs 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229960001474 meclozine Drugs 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229960003729 mesuximide Drugs 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229960000884 nelfinavir Drugs 0.000 description 1
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229960003502 oxybuprocaine Drugs 0.000 description 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229950006460 palinavir Drugs 0.000 description 1
- RXBWRFDZXRAEJT-SZNOJMITSA-N palinavir Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)C=1N=C2C=CC=CC2=CC=1)C(C)C)[C@H](O)CN1[C@@H](C[C@@H](CC1)OCC=1C=CN=CC=1)C(=O)NC(C)(C)C)C1=CC=CC=C1 RXBWRFDZXRAEJT-SZNOJMITSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229960001190 pheniramine Drugs 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011085 pressure filtration Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 229960004134 propofol Drugs 0.000 description 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 229960000311 ritonavir Drugs 0.000 description 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 239000010018 saw palmetto extract Substances 0.000 description 1
- 238000009288 screen filtration Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229960003231 thioacetazone Drugs 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229960004791 tropicamide Drugs 0.000 description 1
- 229960004747 ubidecarenone Drugs 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Detergent Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Water Treatment By Sorption (AREA)
Description
a)0.01〜5μmの粒径を有する水に難溶性の化合物および保護コロイドを、分散剤中に微小分散の形態で含む、分散物の生成、
b)クロスフロー濾過によるこの水に難溶性の化合物の分散物の濃縮、および
c)この残留する分散剤の除去、
を包含する。
− 鎮痛剤/抗リウマチ剤、例えば、コデイン、ジクロフェナク、フェンタニル、ヒドロモルフォン、イブプロフェン、インドメタシン、レボメタドン(levomethadone)、モルヒネ、ナプロキセン、ピリトラミド、ピロキシカム、トラマドール
− 抗アレルギー剤、例えば、アステミゾール、ジメチンデン、ドキシルアミン(doxylamine)、ロラタジン、メクロジン(meclozine)、フェニラミン、テルフェナジン
− 抗生物質/化学療法剤、例えば、エリスロマイシン、フラマイセチン、フシジン酸、リファンピシン、テトラサイクリン、チアセタゾン、チロトリシン
− 抗てんかん剤、例えば、カルバマゼピン、クロナゼパム、メスキシミド(mesuximide)、フェニトイン、バルプロ酸
− 抗真菌剤、例えば、クロトリマゾール、フルコナゾール、イトラコナゾール
− カルシウムチャネル遮断剤、例えば、ダロジピン(darodipine)、イスラジピン
− コルチコイド、例えば、アルドステロン、ベタメタゾン、ブデソニド、デキサメタゾン、フルオコルトロン、フルドロコルチゾン、ヒドロキシコルチゾン(hydroxycortizone)、メチルプレドニゾロン、プレドニゾロン
− 睡眠剤/鎮静剤
ベンゾジアゼピン、シクロバルビタール、メタカロン、フェノバルビタール
− 免疫抑制剤
アザチオプリン、シクロスポリン(サイクロスポリン)
− 局所麻酔剤
ベンゾカイン、ブタニラカイン(butanilacaine)、エチドカイン、リドカイン、オキシブプロカイン、テトラカイン
− ミグラン レメディーズ(migrane remedies)
ジヒドロエルゴタミン、エルゴタミン、リスリド、メチルセルジド
− 麻酔剤
ドロペリドール、エトミデート、フェンタニル、ケタミン、メトヘキシタール、プロポフォール、チオペンタール
− 眼科剤(opthalmologicals)
アセタゾラミド、ベタキソロール、ブプラノロール、カルバコール、カルテオロール、シクロドリン(cyclodrine)、シクロペントレート、ジクロフェナミド、エドクスジン(edoxudine)、ホマトロピン、レボブノロール、フォレドリン、ピンドロール、チモロール、トロピカミド
− 植物治療剤
ヒペリカム、ウルチカ・ホリア(urtica folia)、アーティチョーク、アグナス・カスタス(agnus castus)、シミシフーガ、デビルズ・クロー、エニシダ(broom)、ハッカ油(peppermint oil)、ユーカリ油、クサノオウ、アイビー、カバカバ(kava−kava)、エキナシア、カノコソウ、パルメット(palmetto)、オオアザミ、イチョウ(Ginko biloba)、アロエ・バーバデンシス(Aloe barbadensis)、ニンニク(Allium sativum)、チョウセンニンジン(Panax ginseng)、ソーパルメット(ノコギリヤシ)(Serenoa repens)、ゴールデンシール(ヒドラスチス・カナデンシス)(Hydrastis canadensis)、オオミツルコケモモ(クランベリー)(Vaccinium macrocarpon)またはそれらの混合物
− プロテアーゼインヒビター
例えば、サキナビル、インジナビル、リトナビル、ネルフィナビル、パリナビル(palinavir)、チプラナビルまたはこれらのプロテアーゼインヒビターの組み合わせ
− 性ホルモンおよびそれらのアンタゴニスト
アナボリック、アンドロゲン、抗アンドロゲン、エストラジオール、プロゲスチン、プロゲステロン、エストロゲン、抗エストロゲン、例えばタモキシフェン
− ビタミン、プロビタミン、抗酸化剤、例えば、カロチノイドまたはカロチノイド類似体、例えば、βカロチン、カンタキサンチン、アスタキサンチン、リコペン又はリポ酸、ビタミンA、ビタミンQ
− 細胞増殖抑制剤/抗転移剤
ブスルファン、カルムスチン、クロラムブシル、シクロホスファミド、ダカルバジン、ダクチノマイシン、エストラムスチン、エトポシド、フルロウラシル(flurouracil)、イホスファミド、メトトレキサート、パクリタキセル、ビンブラスチン、ビンクリスチン、ビンデシン。
35.7重量%の補酵素Q10および64.3重量%のカゼインを含有する水分散性の乾燥粉末を生成した。
以下の組成物の水分散性の乾燥粉末を生成した:
濃縮工程前の状態と比べて濃縮の後で、粒径分布に、検出可能な変化はなかった。
黄色がかったコロイド活性成分を含有する溶液であって、総固体含量0.5重量%を有する溶液を、保護コロイドカゼイン(65重量%)および活性成分補酵素Q10(35重量%)を用いて実施例1と同様に生成した。次いで、塩酸水溶液(2mol/l)を段階的に添加することで、この溶液をpH=1に酸性化して、これによってコロイド溶液中に固体の完全な綿状沈殿を生成した。この沈殿物は減圧濾過(濾紙またはガラスフリット(glass frit))によって濾別することが可能であった;この濾液は無色であった。次いで除去された沈殿物を、希水酸化ナトリウム溶液(0.1mol/l)中で室温で撹拌することによって、0.5%の総固体含量の濃度に、再度分散して、黄色がかったコロイド溶液を再度得た。次いで、少量の塩酸を用いて、綿状沈殿なしにこのアルカリ性コロイド溶液をpH7に調整することが可能であった。
Claims (11)
- 水に難溶性の化合物から水分散性の乾燥粉末を得るための製法であって、以下の工程:
a)0.01〜5μmの粒径を有する水に難溶性の化合物および保護コロイドを、分散剤中に微小分散の形態で含む、分散物の生成、
b)クロスフロー濾過による水に難溶性の化合物の該分散物の濃縮、および
c)残留する該分散剤の除去
を包含する、製法。 - 水、および揮発性で水混和性の有機溶媒からなる分散剤が用いられる、請求項1に記載の製法。
- 水に難溶性の化合物を0.5〜3重量%含む分散物が生成され、該分散物が固体含量を10〜40倍に濃縮される、請求項1または2に記載の製法。
- 分散された粒子が0.05〜0.8μmの粒径を有する分散物が生成される、請求項1〜3のいずれかに記載の製法。
- ポリエーテルスルホンまたは再生セルロースから作製された濾過膜が前記クロスフロー濾過に用いられる、請求項1〜4のいずれかに記載の製法。
- 排除限界分子量が100000を超える濾過膜が前記クロスフロー濾過に用いられる、請求項1〜5のいずれかに記載の製法。
- 前記分散剤の除去が噴霧乾燥によって行われる、請求項1〜6のいずれかに記載の製法。
- 前記分散物の生成、該分散物の濃縮、および前記分散剤の除去が連続して生じる、請求項1〜7のいずれかに記載の製法。
- 前記分散物に存在する微小分散した粒子が、前記濃縮の前に可逆的に凝集し、かつ該濃縮の後に微小分散する、請求項1〜8のいずれかに記載の製法。
- 前記分散された粒子が以下:
− 無機塩および/または有機塩の添加、並びに/或いは
− 該分散物の温度を変化させる工程、並びに/或いは
− 該分散物のpHを変化させる工程
によって凝集される、請求項9に記載の製法。 - 請求項1〜10のいずれかに記載の製法によって生成される、水に難溶性の化合物の水分散性の乾燥粉末。
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DE10205362A DE10205362A1 (de) | 2002-02-08 | 2002-02-08 | Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen |
PCT/EP2003/001244 WO2003066019A2 (de) | 2002-02-08 | 2003-02-07 | Verfahren zur herstellung wasserdispergierbarer trockenpulver von in wasser schwer löslichen verbindungen |
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US (1) | US20060269610A1 (ja) |
EP (1) | EP1471883B1 (ja) |
JP (1) | JP4623968B2 (ja) |
CN (1) | CN1274296C (ja) |
AT (1) | ATE312596T1 (ja) |
AU (1) | AU2003218647A1 (ja) |
CA (1) | CA2473720A1 (ja) |
DE (2) | DE10205362A1 (ja) |
ES (1) | ES2254914T3 (ja) |
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US7858607B2 (en) * | 2003-03-14 | 2010-12-28 | Mamchur Stephen A | System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer |
CN1993060A (zh) * | 2004-08-19 | 2007-07-04 | 帝斯曼知识产权资产管理有限公司 | 可脂溶物质的新型组合物 |
WO2007114262A1 (ja) * | 2006-03-29 | 2007-10-11 | Fujifilm Corporation | カゼインナノ粒子 |
JP2008266179A (ja) * | 2007-04-19 | 2008-11-06 | Fujifilm Corp | 経肺用組成物 |
JP2008297241A (ja) * | 2007-05-31 | 2008-12-11 | Fujifilm Corp | ニキビ用皮膚外用剤 |
WO2009001787A1 (ja) * | 2007-06-22 | 2008-12-31 | Kaneka Corporation | 補酵素q10含有組成物 |
EP2172223B1 (en) * | 2007-06-22 | 2020-12-16 | Kaneka Corporation | Composition containing physiologically active substance |
EP2186789B1 (en) * | 2007-08-22 | 2013-12-25 | Kaneka Corporation | Method of producing reduced coenzyme q10 and method of stabilizing the same |
TW200946266A (en) * | 2008-02-27 | 2009-11-16 | Kuraray Co | Method of manufacturing metalnanowire and dispersion medium comprising the resultant metalnanowire, and transparent conductive film |
WO2014078063A2 (en) * | 2012-11-14 | 2014-05-22 | Pepsico, Inc. | Method to improve dispersibility of a material having low solubility in water |
EP3174408B1 (en) * | 2014-08-01 | 2018-12-05 | Firmenich SA | Solid dispersion of amide flavor compounds |
WO2017134072A1 (en) * | 2016-02-03 | 2017-08-10 | Firmenich Sa | Solutions and dispersions of amide compounds |
EP3335716A1 (en) * | 2016-12-15 | 2018-06-20 | Indena S.p.A. | Process for the preparation of powder compositions |
ES2920153T3 (es) * | 2017-12-08 | 2022-08-01 | Chenguang Biotech Group Co Ltd | Polvo de microcápsulas de licopeno y método de preparación para el mismo |
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EP1471883B1 (de) | 2005-12-14 |
CN1274296C (zh) | 2006-09-13 |
AU2003218647A8 (en) | 2003-09-02 |
CA2473720A1 (en) | 2003-08-14 |
AU2003218647A1 (en) | 2003-09-02 |
DE50301918D1 (de) | 2006-01-19 |
JP2005524635A (ja) | 2005-08-18 |
DE10205362A1 (de) | 2003-08-21 |
US20060269610A1 (en) | 2006-11-30 |
CN1627936A (zh) | 2005-06-15 |
ATE312596T1 (de) | 2005-12-15 |
EP1471883A2 (de) | 2004-11-03 |
WO2003066019A3 (de) | 2004-03-11 |
ES2254914T3 (es) | 2006-06-16 |
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