JP4613299B2 - 分析物分析に関する方法、混合物、キット、および組成物 - Google Patents

分析物分析に関する方法、混合物、キット、および組成物 Download PDF

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JP4613299B2
JP4613299B2 JP2006503013A JP2006503013A JP4613299B2 JP 4613299 B2 JP4613299 B2 JP 4613299B2 JP 2006503013 A JP2006503013 A JP 2006503013A JP 2006503013 A JP2006503013 A JP 2006503013A JP 4613299 B2 JP4613299 B2 JP 4613299B2
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JP2007525639A5 (enExample
JP2007525639A (ja
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ダリル ジェイ． シー． パピン，
マイケル バートレット−ジョーンズ，
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ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2006503013A 2003-01-30 2004-01-27 分析物分析に関する方法、混合物、キット、および組成物 Expired - Lifetime JP4613299B2 (ja)

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US44361203P 2003-01-30 2003-01-30
PCT/US2004/002077 WO2004070352A2 (en) 2003-01-30 2004-01-27 Methods, mixtures, kits and compositions pertaining to analyte determination

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US (9) US20040219685A1 (enExample)
EP (1) EP1588145B1 (enExample)
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AT (1) ATE515702T1 (enExample)
AU (2) AU2004209401A1 (enExample)
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WO (1) WO2004070352A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517070A (ja) * 2004-01-05 2007-06-28 アプレラ コーポレイション 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
US7971746B2 (en) 2005-03-14 2011-07-05 Hoshizaki Denki Kabushiki Kaisha Thermally insulated housing

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60003177T2 (de) * 1999-03-18 2004-05-06 602531 British Columbia Ltd., Vancouver Dateneingabe für personalrechnergeräte
AU6770800A (en) * 1999-08-13 2001-03-13 Yale University Analysis of sequence tags with hairpin primers
US20020106648A1 (en) * 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
US6835545B2 (en) 2000-05-08 2004-12-28 President And Fellows Of Harvard College Methods, products and treatments for diabetes
CA2419159A1 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
AU2004209401A1 (en) 2003-01-30 2004-08-19 Applied Biosystems, Llc. Methods, mixtures, kits and compositions pertaining to analyte determination
GB0306756D0 (en) * 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
CA2542941C (en) * 2003-11-26 2013-02-12 Applera Corporation Analysis of mass spectral data in the quiet zones and label selection therefor
EP1916527A1 (en) * 2003-11-26 2008-04-30 Applera Corporation Analysis of mass spectral data in the quiet zones
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US20050148771A1 (en) * 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
JP4613320B2 (ja) 2004-03-01 2011-01-19 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 結合特性に基づく分析物の特徴の決定
EP1766413A2 (en) * 2004-05-19 2007-03-28 Applera Corporation Expression quantification using mass spectrometry
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US8335652B2 (en) * 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
US20050287574A1 (en) * 2004-06-23 2005-12-29 Medtronic, Inc. Genetic diagnostic method for SCD risk stratification
US8027791B2 (en) * 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
US20060172319A1 (en) * 2004-07-12 2006-08-03 Applera Corporation Mass tags for quantitative analyses
US20070048752A1 (en) * 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
CA2838007A1 (en) * 2004-11-15 2006-05-26 University Of North Dakota A method for single oxygen atom incorporation into digested peptides using peptidases
WO2006086098A2 (en) * 2005-01-06 2006-08-17 President And Fellows Of Harvard College Mass spectrometric methods and products
US20070207555A1 (en) * 2005-02-03 2007-09-06 Cesar Guerra Ultra-sensitive detection systems using multidimension signals
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
DE602006014846D1 (de) 2005-09-15 2010-07-22 Alk Abello As Verfahren zur quantifizierung von allergenen
US20080318327A1 (en) * 2006-01-05 2008-12-25 Ge Healthcare Bio-Sciences Ab Kit and Method for Mass Labelling
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US20070185346A1 (en) * 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
US7982070B2 (en) 2006-03-21 2011-07-19 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
CN101454488A (zh) * 2006-05-26 2009-06-10 阿普里拉股份有限公司 用于羟基化化合物的标签试剂和方法
US8580534B2 (en) * 2006-06-30 2013-11-12 The University Of North Dakota Method for incorporation of two oxygen atoms into digested peptides using peptidases
US8362242B2 (en) * 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US7906341B2 (en) * 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
EP1918714A1 (en) * 2006-11-02 2008-05-07 Koninklijke Philips Electronics N.V. Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
EP1921081A1 (en) 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
US7951608B2 (en) * 2007-05-04 2011-05-31 Perkinelmer Health Sciences, Inc. Detecting succinylacetone
WO2009003188A2 (en) * 2007-06-27 2008-12-31 Cedars-Sinai Medical Center N-terminal specific chemical labeling for proteomics applications
US20090028791A1 (en) * 2007-07-25 2009-01-29 Balatoni Julius A Dichloroacetate Analogs as Imaging Agents
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7982180B2 (en) * 2007-09-10 2011-07-19 Dh Technologies Development Pte. Ltd. Methods and systems for analysis and correction of mass spectrometer data
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
EP2212690A4 (en) * 2007-11-06 2011-03-30 Translational Therapeutics Inc MASS SPECTROMETRY ANALYSIS OF THE ACTIVITY OF ELF4E AND ELF4E REGULON
US20110143956A1 (en) * 2007-11-14 2011-06-16 Medtronic, Inc. Diagnostic Kits and Methods for SCD or SCA Therapy Selection
US20090136954A1 (en) * 2007-11-14 2009-05-28 Medtronic, Inc. Genetic markers for scd or sca therapy selection
EP2108957A1 (en) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Compounds and methods for the labelling and affinity-selection of proteins
GB0809488D0 (en) * 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
US8486712B2 (en) 2009-03-10 2013-07-16 University Of Maryland, College Park Deuterium isobaric tag reagents for quantitative analysis
US8592216B2 (en) 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
WO2010132546A2 (en) * 2009-05-12 2010-11-18 Medtronic, Inc. Sca risk stratification by predicting patient response to anti-arrhythmics
US20110003395A1 (en) 2009-05-31 2011-01-06 Dh Technologies Development Pte. Ltd. Specific analysis of analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
GB0916881D0 (en) 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
US20110143445A1 (en) * 2009-12-15 2011-06-16 Dh Technologies Development Pte. Ltd. Analysis of Amino Acids And Amine-Containing Compounds Using Tagging Reagents and LC-MS Workflow
US8309359B2 (en) * 2010-01-15 2012-11-13 California Institute Of Technology Isobaric tags for analyte detection and quantification
EP2528443B1 (en) 2010-01-25 2017-01-11 DH Technologies Development Pte. Ltd. Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
CA2799750A1 (en) 2010-05-17 2011-11-24 The Uab Research Foundation A general mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency
US8835361B2 (en) * 2010-06-01 2014-09-16 The Curators Of The University Of Missouri High-throughput quantitation of crop seed proteins
WO2012027555A2 (en) 2010-08-25 2012-03-01 President And Fellows Of Harvard College Glycated cd59 peptides, their preparation, and uses thereof
DE102011053684B4 (de) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers
JP5711948B2 (ja) * 2010-12-02 2015-05-07 良雄 林 固相担持型ｓｈ基選択的標識試薬
JP5454462B2 (ja) * 2010-12-22 2014-03-26 株式会社島津製作所 クロマトグラフ質量分析装置
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
MX377572B (es) 2011-02-10 2025-03-10 Harvard College Sustitutos de proteínas modificadas post-traduccionalmente y usos de los mismos.
US9040903B2 (en) 2011-04-04 2015-05-26 Wisconsin Alumni Research Foundation Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
US9874575B2 (en) 2012-01-20 2018-01-23 Dh Technologies Development Pte. Ltd. Analysis of estradiol and analytes with phenolic OH using labeling chemistry and LC-MSMS workflow
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
EP2850430B1 (en) 2012-05-18 2017-04-19 Dh Technologies Development Pte. Ltd. Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow
WO2014013051A1 (en) 2012-07-19 2014-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method of predicting or diagnosing an hepatic encephalopathy in patients with cirrhosis treated with transjugular intra-hepatic porto-systemic shunt (tips)
US9366678B2 (en) 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
GB201410523D0 (en) * 2014-06-12 2014-07-30 Electrophoretics Ltd Mass labels
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
GB201521903D0 (en) * 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
CN109311803A (zh) * 2016-06-29 2019-02-05 株式会社日立高新技术 酶反应及质量分析方法中使用的化合物
WO2018141821A1 (en) 2017-01-31 2018-08-09 Roche Diagnostics Gmbh Reagent for mass spectrometry
WO2019096852A1 (en) * 2017-11-14 2019-05-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uses of isobaric tags in mass spectrometry
JP7547315B2 (ja) * 2018-07-24 2024-09-09 エフ． ホフマン－ラ ロシュ アーゲー 質量分析のための試薬
BR112021001061A2 (pt) 2018-07-24 2021-04-20 F. Hoffmann-La Roche Ag composto, composição, kit, aduto covalente, uso de um composto e método para a determinação de espectrometria de massa
WO2020020850A1 (en) * 2018-07-24 2020-01-30 F. Hoffmann-La Roche Ag Reagent for mass spectrometry
CN112146967A (zh) * 2019-06-28 2020-12-29 Fei 公司 用于制备和递送用于带电粒子分析的生物样品的系统和方法
EP3910341A1 (en) * 2020-05-13 2021-11-17 PreOmics GmbH Sample preparation for mass spectrometry

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860581A (en) 1972-12-27 1975-01-14 American Home Prod Preparation of 1,4-benzodiazepines
AU5940186A (en) 1985-07-05 1987-01-08 Institut Fur Pflanzenschutzforschung 2, 6 - dimethyl - morpholine quartenary compounds
US4761415A (en) 1986-08-28 1988-08-02 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5087815A (en) 1989-11-08 1992-02-11 Schultz J Albert High resolution mass spectrometry of recoiled ions for isotopic and trace elemental analysis
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
WO1993024834A1 (en) 1992-05-29 1993-12-09 The Rockefeller University Method and product for the sequence determination of peptides using a mass spectrometer
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
AU7247896A (en) 1995-09-29 1997-04-17 Scripps Research Institute, The Protein signature analysis
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
EP0863858B1 (en) * 1996-04-08 2004-02-04 Glaxo Group Limited Mass-based encoding and qualitative analysis of combinatorial libraries
US5780232A (en) * 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US6329180B1 (en) 1996-09-13 2001-12-11 Alex M. Garvin Genetic analysis using peptide tagged in-vitro synthesized proteins
GB9620769D0 (en) 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
DE69723096T2 (de) 1996-10-04 2004-05-06 Dako A/S Sonden zur detektion von mycobakterien
DE69735445T2 (de) 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
EP0979305B1 (en) 1997-01-15 2006-09-27 Xzillion GmbH & CO.KG Mass label linked hybridisation probes
DE69817211T2 (de) 1997-01-23 2004-06-03 Xzillion Gmbh & Co. Kg Charakterisierung von polypeptiden
IL133948A0 (en) 1997-07-11 2001-04-30 Brax Group Ltd Characterising nucleic acids
CA2297158C (en) 1997-07-22 2009-12-22 Rapigene Inc. Methods and compounds for analyzing nucleic acids by mass spectrometry
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
EP1015632A1 (en) 1997-09-15 2000-07-05 Brax Group Limited Characterising nucleic acid by mass spectrometry
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
WO1999049293A2 (en) * 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
EP1073767B1 (en) * 1998-04-29 2009-11-25 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6270976B1 (en) * 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
GB9821669D0 (en) 1998-10-05 1998-12-02 Glaxo Group Ltd Chemical constructs and their uses
US6319476B1 (en) 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
AU6770800A (en) * 1999-08-13 2001-03-13 Yale University Analysis of sequence tags with hairpin primers
US6472156B1 (en) 1999-08-30 2002-10-29 The University Of Utah Homogeneous multiplex hybridization analysis by color and Tm
GB0006141D0 (en) * 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
AUPQ664300A0 (en) * 2000-04-03 2000-05-04 Proteome Systems Ltd Macromolecule detection
US20020106648A1 (en) 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
CA2419159A1 (en) 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
CA2426728A1 (en) 2000-10-23 2002-06-13 Genetics Institute, Llc. Isotope-coded ionization-enhancing reagents (icier) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
GB0115581D0 (en) 2001-06-26 2001-08-15 Glaxo Group Ltd Method of mass spectometry
GB0116143D0 (en) * 2001-07-02 2001-08-22 Amersham Pharm Biotech Uk Ltd Chemical capture reagent
US7732378B2 (en) 2001-09-14 2010-06-08 Electrophoretics Limited Mass labels
WO2003040288A2 (de) 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopencodierte affinitätsmarker 3
ES2284783T3 (es) * 2001-11-16 2007-11-16 Randox Laboratories Ltd. Metodo y estuche para detectar, o determinar la cantidad de,metabolitos de fentanilo y metabolitos de analogos de fentanilo.
GB0130845D0 (en) 2001-12-22 2002-02-06 James Peter Analysis
WO2003078584A2 (en) 2002-03-11 2003-09-25 Thermo Finnigan, Llc Identifying peptide modifications
DE60325847D1 (de) 2002-03-11 2009-03-05 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
AU2003259029A1 (en) 2002-06-04 2003-12-19 The Institute For Systems Biology Methods for high throughput and quantitative proteome analysis
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7425451B2 (en) * 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
AU2004209401A1 (en) * 2003-01-30 2004-08-19 Applied Biosystems, Llc. Methods, mixtures, kits and compositions pertaining to analyte determination
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050147982A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US20060172319A1 (en) * 2004-07-12 2006-08-03 Applera Corporation Mass tags for quantitative analyses

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517070A (ja) * 2004-01-05 2007-06-28 アプレラ コーポレイション 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
JP4832312B2 (ja) * 2004-01-05 2011-12-07 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
US7971746B2 (en) 2005-03-14 2011-07-05 Hoshizaki Denki Kabushiki Kaisha Thermally insulated housing
US8028394B2 (en) 2005-03-14 2011-10-04 Hoshizaki Denki Kabushiki Kaisha Manufacturing method of a thermally insulated housing

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