JP2007525639A5 - - Google Patents

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JP2007525639A5
JP2007525639A5 JP2006503013A JP2006503013A JP2007525639A5 JP 2007525639 A5 JP2007525639 A5 JP 2007525639A5 JP 2006503013 A JP2006503013 A JP 2006503013A JP 2006503013 A JP2006503013 A JP 2006503013A JP 2007525639 A5 JP2007525639 A5 JP 2007525639A5
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analyte
mass
sample
reporter
labeled
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JP4613299B2 (ja
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JP2006503013A 2003-01-30 2004-01-27 分析物分析に関する方法、混合物、キット、および組成物 Expired - Lifetime JP4613299B2 (ja)

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US44361203P 2003-01-30 2003-01-30
PCT/US2004/002077 WO2004070352A2 (en) 2003-01-30 2004-01-27 Methods, mixtures, kits and compositions pertaining to analyte determination

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JP2007525639A JP2007525639A (ja) 2007-09-06
JP2007525639A5 true JP2007525639A5 (enExample) 2008-03-06
JP4613299B2 JP4613299B2 (ja) 2011-01-12

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US (9) US7799576B2 (enExample)
EP (1) EP1588145B1 (enExample)
JP (2) JP4613299B2 (enExample)
AT (1) ATE515702T1 (enExample)
AU (2) AU2004209401A1 (enExample)
CA (1) CA2488584C (enExample)
WO (1) WO2004070352A2 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1171813B1 (en) * 1999-03-18 2003-06-04 602531 British Columbia Ltd. Data entry for personal computing devices
EP1206577B1 (en) * 1999-08-13 2006-03-01 Yale University Binary encoded sequence tags
WO2001086296A2 (en) * 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
US6835545B2 (en) 2000-05-08 2004-12-28 President And Fellows Of Harvard College Methods, products and treatments for diabetes
CA2419159A1 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US7799576B2 (en) * 2003-01-30 2010-09-21 Dh Technologies Development Pte. Ltd. Isobaric labels for mass spectrometric analysis of peptides and method thereof
GB0306756D0 (en) * 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
EP1916527A1 (en) * 2003-11-26 2008-04-30 Applera Corporation Analysis of mass spectral data in the quiet zones
EP1687638B1 (en) * 2003-11-26 2007-10-31 Applera Corporation Analysis of mass spectral data in the quiet zones
JP4832312B2 (ja) * 2004-01-05 2011-12-07 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
DE602005001302T2 (de) * 2004-03-01 2008-02-14 Applera Corp., Framingham Bestimmung von analytcharakteristika auf der grundlage von bindungseigenschaften
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
JP2007538262A (ja) * 2004-05-19 2007-12-27 アプレラ コーポレイション 質量分析を使用する発現の定量化
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US8027791B2 (en) * 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
US20050287574A1 (en) * 2004-06-23 2005-12-29 Medtronic, Inc. Genetic diagnostic method for SCD risk stratification
US8335652B2 (en) * 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
US20070048752A1 (en) * 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
CA2572754A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses
US7476546B2 (en) * 2004-11-15 2009-01-13 University Of North Dakota Method for single oxygen atom incorporation into digested peptides using peptidases
US7833725B2 (en) * 2005-01-06 2010-11-16 President And Fellows Of Harvard College Mass spectrometric methods and products
US20070207555A1 (en) * 2005-02-03 2007-09-06 Cesar Guerra Ultra-sensitive detection systems using multidimension signals
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
JP4242358B2 (ja) 2005-03-14 2009-03-25 ホシザキ電機株式会社 断熱箱体及びその製造方法
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
DE602006014846D1 (de) 2005-09-15 2010-07-22 Alk Abello As Verfahren zur quantifizierung von allergenen
US20080318327A1 (en) * 2006-01-05 2008-12-25 Ge Healthcare Bio-Sciences Ab Kit and Method for Mass Labelling
US8975404B2 (en) * 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US20070185346A1 (en) * 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
US7982070B2 (en) 2006-03-21 2011-07-19 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
EP2054540B1 (en) * 2006-05-26 2014-11-26 DH Technologies Development Pte. Ltd. Tagging reagents and methods for hydroxylated compounds
US7906341B2 (en) 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US8580534B2 (en) * 2006-06-30 2013-11-12 The University Of North Dakota Method for incorporation of two oxygen atoms into digested peptides using peptidases
US8362242B2 (en) 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
EP1918714A1 (en) * 2006-11-02 2008-05-07 Koninklijke Philips Electronics N.V. Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
EP1921081A1 (en) 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
US7951608B2 (en) * 2007-05-04 2011-05-31 Perkinelmer Health Sciences, Inc. Detecting succinylacetone
US20110159523A1 (en) * 2007-06-27 2011-06-30 Cedars-Sinai Medical Center N-terminal specific chemical labeling for proteomics applications
US20090028791A1 (en) * 2007-07-25 2009-01-29 Balatoni Julius A Dichloroacetate Analogs as Imaging Agents
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7982180B2 (en) * 2007-09-10 2011-07-19 Dh Technologies Development Pte. Ltd. Methods and systems for analysis and correction of mass spectrometer data
WO2009061904A2 (en) * 2007-11-06 2009-05-14 Translational Therapeutics, Inc. MASS SPECTROMETRY ASSAY FOR eIF4E AND eIF4E REGULON ACTIVITY
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
EP2222877A4 (en) * 2007-11-14 2011-10-12 Medtronic Inc GENETIC MARKERS FOR SCD OR SCA THERAPY SELECTION
US20110143956A1 (en) * 2007-11-14 2011-06-16 Medtronic, Inc. Diagnostic Kits and Methods for SCD or SCA Therapy Selection
EP2108957A1 (en) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Compounds and methods for the labelling and affinity-selection of proteins
GB0809488D0 (en) * 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
US8486712B2 (en) 2009-03-10 2013-07-16 University Of Maryland, College Park Deuterium isobaric tag reagents for quantitative analysis
US8592216B2 (en) 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
EP2430184A2 (en) * 2009-05-12 2012-03-21 Medtronic, Inc. Sca risk stratification by predicting patient response to anti-arrhythmics
WO2010141075A1 (en) 2009-05-31 2010-12-09 Dh Technologies Development Pte. Ltd. Specific analysis of ketone and aldehyde analytes using reagent compounds labeling strategies, and mass spectrometry workflow
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
CA2784495A1 (en) * 2009-12-15 2011-06-23 Dh Technologies Development Pte. Ltd. Analysis of amino acids and amine-containing compounds using tagging reagents and lc-ms workflow
US8309359B2 (en) * 2010-01-15 2012-11-13 California Institute Of Technology Isobaric tags for analyte detection and quantification
US8617898B2 (en) 2010-01-25 2013-12-31 Dh Technologies Development Pte. Ltd. Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
US8658355B2 (en) 2010-05-17 2014-02-25 The Uab Research Foundation General mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency
US8835361B2 (en) * 2010-06-01 2014-09-16 The Curators Of The University Of Missouri High-throughput quantitation of crop seed proteins
US9068006B2 (en) 2010-08-25 2015-06-30 President And Fellows Of Harvard College Glycated CD59 peptides, their preparation, and uses thereof
US8742333B2 (en) 2010-09-17 2014-06-03 Wisconsin Alumni Research Foundation Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
JP5711948B2 (ja) * 2010-12-02 2015-05-07 良雄 林 固相担持型sh基選択的標識試薬
JP5454462B2 (ja) * 2010-12-22 2014-03-26 株式会社島津製作所 クロマトグラフ質量分析装置
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US9417248B2 (en) 2011-02-10 2016-08-16 President And Fellows Of Harvard College Surrogates of post-translationally modified proteins and uses thereof
US9040903B2 (en) 2011-04-04 2015-05-26 Wisconsin Alumni Research Foundation Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
CN104040332B (zh) 2012-01-20 2017-10-20 Dh科技发展私人贸易有限公司 使用标记化学和lc‑msms工作流分析具有酚系oh的雌二醇和分析物
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
EP2850430B1 (en) 2012-05-18 2017-04-19 Dh Technologies Development Pte. Ltd. Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow
WO2014013051A1 (en) 2012-07-19 2014-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method of predicting or diagnosing an hepatic encephalopathy in patients with cirrhosis treated with transjugular intra-hepatic porto-systemic shunt (tips)
US9366678B2 (en) 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
GB201410523D0 (en) * 2014-06-12 2014-07-30 Electrophoretics Ltd Mass labels
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
GB201521903D0 (en) * 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
CN109311803A (zh) * 2016-06-29 2019-02-05 株式会社日立高新技术 酶反应及质量分析方法中使用的化合物
JP7153652B2 (ja) * 2017-01-31 2022-10-14 エフ.ホフマン-ラ ロシュ アーゲー 質量分析用の試薬
US11355330B2 (en) * 2017-11-14 2022-06-07 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaf 1 En E.V. Uses of isobaric tags in mass spectrometry
EP3826994A1 (en) * 2018-07-24 2021-06-02 F. Hoffmann-La Roche AG Reagent for mass spectrometry
JP7547313B2 (ja) 2018-07-24 2024-09-09 エフ. ホフマン-ラ ロシュ アーゲー 質量分析のための試薬
CN112449636A (zh) * 2018-07-24 2021-03-05 豪夫迈·罗氏有限公司 用于质谱分析的试剂
CN112146967A (zh) * 2019-06-28 2020-12-29 Fei 公司 用于制备和递送用于带电粒子分析的生物样品的系统和方法
EP3910341A1 (en) * 2020-05-13 2021-11-17 PreOmics GmbH Sample preparation for mass spectrometry

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860581A (en) 1972-12-27 1975-01-14 American Home Prod Preparation of 1,4-benzodiazepines
AU5940186A (en) * 1985-07-05 1987-01-08 Institut Fur Pflanzenschutzforschung 2, 6 - dimethyl - morpholine quartenary compounds
US4761415A (en) 1986-08-28 1988-08-02 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5087815A (en) * 1989-11-08 1992-02-11 Schultz J Albert High resolution mass spectrometry of recoiled ions for isotopic and trace elemental analysis
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
EP1130399B1 (en) * 1992-05-29 2009-04-01 The Rockefeller University Method for the sequence determination of peptides using a mass spectrometer
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US6495314B1 (en) 1995-09-29 2002-12-17 The Scripps Research Institute Process for characterizing proteins
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) * 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
ATE258904T1 (de) 1996-04-08 2004-02-15 Glaxo Group Ltd Auf masse basierte kodierung und qualitative analyse von kombinatorischen bibliotheken
US5780232A (en) * 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US6329180B1 (en) * 1996-09-13 2001-12-11 Alex M. Garvin Genetic analysis using peptide tagged in-vitro synthesized proteins
AU4549997A (en) 1996-10-04 1998-05-05 Dako A/S Novel probes for the detection of mycobacteria
GB9620769D0 (en) 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
WO1998031830A1 (en) 1997-01-15 1998-07-23 Brax Group Limited Mass label linked hybridisation probes
DE69817211T2 (de) 1997-01-23 2004-06-03 Xzillion Gmbh & Co. Kg Charakterisierung von polypeptiden
WO1999002728A1 (en) 1997-07-11 1999-01-21 Brax Group Limited Characterising nucleic acids
ATE240408T1 (de) 1997-07-22 2003-05-15 Qiagen Genomics Inc Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
WO1999014362A1 (en) 1997-09-15 1999-03-25 Brax Group Limited Characterising nucleic acid by mass spectrometry
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
AU3775099A (en) * 1998-04-29 1999-11-16 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6270976B1 (en) * 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
GB9821669D0 (en) 1998-10-05 1998-12-02 Glaxo Group Ltd Chemical constructs and their uses
US6319476B1 (en) 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
US6403309B1 (en) 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
EP1206577B1 (en) 1999-08-13 2006-03-01 Yale University Binary encoded sequence tags
US6472156B1 (en) * 1999-08-30 2002-10-29 The University Of Utah Homogeneous multiplex hybridization analysis by color and Tm
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
AUPQ664300A0 (en) * 2000-04-03 2000-05-04 Proteome Systems Ltd Macromolecule detection
WO2001086296A2 (en) 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
CA2419159A1 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
WO2002046770A2 (en) 2000-10-23 2002-06-13 Genetics Institute, Llc Isotope-coded ionization-enhancing reagents (icier) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
GB0115581D0 (en) 2001-06-26 2001-08-15 Glaxo Group Ltd Method of mass spectometry
GB0116143D0 (en) * 2001-07-02 2001-08-22 Amersham Pharm Biotech Uk Ltd Chemical capture reagent
DK1425586T3 (da) 2001-09-14 2008-02-11 Electrophoretics Ltd Massemarkörer
EP1446665A2 (de) * 2001-11-09 2004-08-18 Bayer HealthCare AG Isotopencodierte affinitätsmarker 3
CN100402084C (zh) * 2001-11-16 2008-07-16 兰多克斯实验室有限公司 检测或定量芬太尼或其类似物的代谢物的方法和试剂盒
GB0130845D0 (en) 2001-12-22 2002-02-06 James Peter Analysis
WO2003077851A2 (en) 2002-03-11 2003-09-25 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
JP2005520141A (ja) 2002-03-11 2005-07-07 サーモ フィニガン エルエルシー ペプチド改変の同定
WO2003102220A2 (en) 2002-06-04 2003-12-11 The Institute For Systems Biology Methods for high throughput and quantitative proteome analysis
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7425451B2 (en) * 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
US7799576B2 (en) * 2003-01-30 2010-09-21 Dh Technologies Development Pte. Ltd. Isobaric labels for mass spectrometric analysis of peptides and method thereof
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US20050147982A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148771A1 (en) * 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
CA2572754A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses

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