JP4612990B2 - ヒスタミン−３受容体リガンドとしての新規アミンおよびそれらの治療的適用 - Google Patents

ヒスタミン−３受容体リガンドとしての新規アミンおよびそれらの治療的適用 Download PDF

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JP4612990B2
JP4612990B2 JP2002573767A JP2002573767A JP4612990B2 JP 4612990 B2 JP4612990 B2 JP 4612990B2 JP 2002573767 A JP2002573767 A JP 2002573767A JP 2002573767 A JP2002573767 A JP 2002573767A JP 4612990 B2 JP4612990 B2 JP 4612990B2
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Prior art keywords
ethyl
benzofuran
methyl
pyrrolidinyl
pyrrolidin
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Expired - Fee Related
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JP2005500986A (ja
JP2005500986A5 (enExample
Inventor
コワート，マーロン・デイー
ベンナニ，ユセフ・エル
フアギー，ラミン
グフエサー，グレゴリー・エイ
ブラツク，ローレンス・エイ
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Abbott Laboratories
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Abbott Laboratories
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Priority claimed from US09/810,648 external-priority patent/US20020177589A1/en
Priority claimed from US10/044,495 external-priority patent/US20020183309A1/en
Priority claimed from US10/081,207 external-priority patent/US6969730B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JP2005500986A publication Critical patent/JP2005500986A/ja
Publication of JP2005500986A5 publication Critical patent/JP2005500986A5/ja
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JP2002573767A 2001-03-16 2002-03-11 ヒスタミン−３受容体リガンドとしての新規アミンおよびそれらの治療的適用 Expired - Fee Related JP4612990B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/810,648 US20020177589A1 (en) 2001-03-16 2001-03-16 Novel amines as histamine-3 receptor ligands and their therapeutic applications
US10/044,495 US20020183309A1 (en) 2001-03-16 2002-01-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications
US10/081,207 US6969730B2 (en) 2001-03-16 2002-02-25 Amines as histamine-3 receptor ligands and their therapeutic applications
PCT/US2002/007107 WO2002074758A2 (en) 2001-03-16 2002-03-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications

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JP2005500986A JP2005500986A (ja) 2005-01-13
JP2005500986A5 JP2005500986A5 (enExample) 2005-12-22
JP4612990B2 true JP4612990B2 (ja) 2011-01-12

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EP (2) EP1370546A2 (enExample)
JP (1) JP4612990B2 (enExample)
AR (1) AR035783A1 (enExample)
BR (1) BR0205829A (enExample)
CA (1) CA2440238C (enExample)
MX (1) MXPA03008319A (enExample)
WO (1) WO2002074758A2 (enExample)

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Publication number Priority date Publication date Assignee Title
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
US6822101B2 (en) 2002-09-16 2004-11-23 Abbott Laboratories Process for preparing amine-substituted benzofurans
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
WO2004043458A1 (en) * 2002-11-12 2004-05-27 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
US7244852B2 (en) 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
JP4736043B2 (ja) 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
CA2521000A1 (en) * 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. Preventive and/or therapeutic agent for neuropathic pain
US7094790B2 (en) 2003-05-07 2006-08-22 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
EP1620434B1 (en) * 2003-05-07 2011-03-09 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
US20040224952A1 (en) * 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
EP1723126A2 (en) * 2003-10-22 2006-11-22 Eli Lilly And Company Novel mch receptor antagonists
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2005085214A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd ジアリール置換複素５員環誘導体
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
US7205316B2 (en) 2004-05-12 2007-04-17 Abbott Laboratories Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
US20050256118A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
US20050256309A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
DE102004030099A1 (de) * 2004-06-22 2006-01-12 Grünenthal GmbH Gesättigte und ungesättigte 3-Pyridyl-benzocycloalkylmethyl-amine als Serotonin- und/oder Noradrenalin-Reuptake-Hemmer und/oder µ-Opioidrezeptor-Modulatoren
AU2005283326B2 (en) 2004-09-13 2011-07-21 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
ATE530519T1 (de) * 2005-06-03 2011-11-15 Abbott Lab Cyclobutylaminderivate
CA2644368A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
WO2007149395A2 (en) * 2006-06-20 2007-12-27 Amphora Discovery Corporation 2,5-substituted oxazole derivatives as protein kinase inhibitors for the treatment of cancer
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
KR20090024811A (ko) 2006-06-23 2009-03-09 아보트 러보러터리즈 히스타민 ｈ3 수용체 조절제로서의 사이클로프로필 아민 유도체
CA2705502C (en) * 2007-11-13 2016-01-26 Taisho Pharmaceutical Co., Ltd. Phenylpyrazole derivatives
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
AU2009304596A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1P receptors modulators
CA2740484C (en) * 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
JP2012082186A (ja) * 2010-09-15 2012-04-26 Bayer Cropscience Ag 殺虫性アリールピロリジン類
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
ES2647965T3 (es) * 2013-01-09 2017-12-27 Arena Pharmaceuticals, Inc. Derivados de bifenil-etil-pirrolidina como moduladores del receptor de histamina H3 para el tratamiento de trastornos cognitivos
EP3236964A4 (en) * 2014-12-22 2018-09-19 Teva Pharmaceuticals International GmbH L-tartrate salt of pridopidine
CN109456292B (zh) * 2018-10-23 2022-06-10 中山大学 一种海洋真菌来源的香豆素类化合物及其制备方法与应用
WO2022113008A1 (en) 2020-11-27 2022-06-02 Richter Gedeon Nyrt. Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder
CN114805261B (zh) * 2021-01-18 2023-03-21 沈阳药科大学 苯并呋喃类lsd1抑制剂及其制备方法
CN115385885A (zh) * 2022-05-05 2022-11-25 深圳海创生物科技有限公司 一种蓝莓多酚、组合物及其在制备具有降血脂和/或减肥作用的药物或食品中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237144A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans
IL101785A0 (en) * 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
JP2759257B2 (ja) * 1993-09-28 1998-05-28 大塚製薬株式会社 糖尿病治療剤
JPH07173158A (ja) * 1993-12-17 1995-07-11 Taiho Yakuhin Kogyo Kk チアゾリジンジオン誘導体又はその塩
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6130187A (en) * 1996-02-09 2000-10-10 Kumiai Chemical Industry Co., Ltd. Benzofuran-7-yl uracil derivatives and herbicides
US6077812A (en) * 1997-02-26 2000-06-20 Fmc Corporation Cycloimido-substituted benzofused heterocyclic herbicides
WO1998052946A1 (en) * 1997-12-02 1998-11-26 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension
EP0978512A1 (en) * 1998-07-29 2000-02-09 Societe Civile Bioprojet Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
EP0982300A3 (en) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents

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