JP4612418B2 - 吸入器 - Google Patents

吸入器 Download PDF

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Publication number
JP4612418B2
JP4612418B2 JP2004537331A JP2004537331A JP4612418B2 JP 4612418 B2 JP4612418 B2 JP 4612418B2 JP 2004537331 A JP2004537331 A JP 2004537331A JP 2004537331 A JP2004537331 A JP 2004537331A JP 4612418 B2 JP4612418 B2 JP 4612418B2
Authority
JP
Japan
Prior art keywords
indicator member
inhaler
wheel
flow path
air flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2004537331A
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English (en)
Japanese (ja)
Other versions
JP2006500094A5 (enExample
JP2006500094A (ja
Inventor
ダンカン・グラント・ヤング
サイモン・ポール・ウェルズ
アンドルー・ジェイムズ・レッジウェイ
グレアム・キース・レイシー
ジュリアン・フランシス・ラルフ・スウォン
Original Assignee
アベンティス・フアーマ・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アベンティス・フアーマ・リミテッド filed Critical アベンティス・フアーマ・リミテッド
Publication of JP2006500094A publication Critical patent/JP2006500094A/ja
Publication of JP2006500094A5 publication Critical patent/JP2006500094A5/ja
Application granted granted Critical
Publication of JP4612418B2 publication Critical patent/JP4612418B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/041—Design features of general application for driving the stage of lowest order for drum-type indicating means
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G06M1/163—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism with drums
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/241—Drums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2004537331A 2002-09-21 2003-09-17 吸入器 Expired - Lifetime JP4612418B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222023.4A GB0222023D0 (en) 2002-09-21 2002-09-21 Inhaler
PCT/GB2003/004137 WO2004026380A2 (en) 2002-09-21 2003-09-17 Inhaler

Publications (3)

Publication Number Publication Date
JP2006500094A JP2006500094A (ja) 2006-01-05
JP2006500094A5 JP2006500094A5 (enExample) 2006-09-07
JP4612418B2 true JP4612418B2 (ja) 2011-01-12

Family

ID=9944580

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004537331A Expired - Lifetime JP4612418B2 (ja) 2002-09-21 2003-09-17 吸入器

Country Status (14)

Country Link
EP (1) EP1542750B1 (enExample)
JP (1) JP4612418B2 (enExample)
KR (1) KR20050046800A (enExample)
CN (1) CN1684731A (enExample)
AT (1) ATE423590T1 (enExample)
AU (1) AU2003267633A1 (enExample)
BR (1) BR0314127A (enExample)
CA (1) CA2499486A1 (enExample)
DE (1) DE60326366D1 (enExample)
GB (1) GB0222023D0 (enExample)
MX (1) MXPA05003056A (enExample)
RU (1) RU2323749C2 (enExample)
WO (1) WO2004026380A2 (enExample)
ZA (1) ZA200502219B (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0328635D0 (en) 2003-12-10 2004-01-14 3M Innovative Properties Co Dose counter for dispensers
KR101105909B1 (ko) 2004-02-16 2012-01-17 글락소 그룹 리미티드 약품 분배기에 사용되는 카운터
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
GB2414187B (en) * 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
UA93031C2 (uk) * 2004-07-16 2011-01-10 Алміралл, С.А. Інгалятор для порошкових медикаментів, фармацевтичний порошковий картридж для використання з інгалятором та спосіб використання інгалятора
WO2006016726A1 (ja) * 2004-08-12 2006-02-16 Idec Corporation 供給装置のカウンタ機構及びカウンタ機構を備えた供給装置
GB2429166A (en) * 2005-07-27 2007-02-21 Cambridge Consultants Inhaler counter
GB0518400D0 (en) 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
GB0600070D0 (en) * 2006-01-04 2006-02-15 Campling Nicholas J Dose counter
GB0605150D0 (en) 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
EP2010125B1 (en) 2006-04-21 2017-01-04 3M Innovative Properties Company Dose counter
GB0610541D0 (en) 2006-05-26 2006-07-05 Bespak Plc Improvements in or relating to dispensing apparatus
GB2448839B (en) * 2006-05-26 2009-05-27 Consort Medical Plc Improvements in or relating to dispensing apparatus
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
BRPI0809974A2 (pt) 2007-03-30 2014-10-07 Sanofi Aventis Compostos de pirimidina hidrazida como inibidores de pgds
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
TWI677355B (zh) * 2008-06-13 2019-11-21 美商曼凱公司 用於藥物傳輸之乾粉吸入器及系統
GB201020130D0 (en) * 2010-11-26 2011-01-12 Vectura Delivery Devices Ltd Inhaler
DE202008017185U1 (de) * 2008-12-30 2010-05-12 Siegfried Generics International Ag Dosiervorrichtung
US9125999B2 (en) 2009-05-18 2015-09-08 Adamis Pharmaceuticals Corporation Dry powder inhaler dose counters
BR112012007635B1 (pt) 2009-10-08 2019-07-09 Sanofi Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação
EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc DATA COLLECTION SYSTEM FOR TWO WRIST
SG182825A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Data gathering system
EP2563813B1 (en) 2010-04-30 2015-08-26 Alexion Pharmaceuticals, Inc. Anti-c5a antibodies and methods for using the antibodies
SG186397A1 (en) 2010-06-22 2013-01-30 Univ Colorado Regents Antibodies to the c3d fragment of complement component 3
GB201118842D0 (en) * 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser cap arrangement
WO2013114373A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Inhalable liquid formulations of dnase i
DK3421042T3 (da) 2012-03-07 2024-07-22 Beyond Air Ltd Indånding af nitrogenoxid til behandling af luftvejssygdomme
US9489615B2 (en) 2012-05-04 2016-11-08 Sanofi Sa Counting mechanism for a drug delivery device and drug delivery device
GB201223008D0 (en) * 2012-12-20 2013-01-30 Euro Celtique Sa Counter
ES2768648T3 (es) 2013-03-29 2020-06-23 Alexion Pharma Inc Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento
RU2544801C2 (ru) * 2013-06-11 2015-03-20 Открытое Акционерное Общество "Фармацевтическая Фабрика Санкт-Петербурга" Порошковый ингалятор
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
TW201636068A (zh) * 2015-01-13 2016-10-16 賽諾菲股份有限公司 藥物輸送裝置之組件
EP3294389B1 (en) * 2015-05-08 2020-07-22 Iconovo AB Dry powder inhaler comprising a locking mechanism
WO2017128170A1 (zh) * 2016-01-28 2017-08-03 扬子江药业集团有限公司 一种储库型干粉吸入器
EP3222314B1 (en) * 2016-03-21 2018-11-21 Joseph Feldman Nasal spray apparatus
WO2017205101A1 (en) 2016-05-27 2017-11-30 Alexion Pharmaceuticals, Inc. Methods for treatment of refractory generalized myasthenia gravis
GB201610450D0 (en) 2016-06-15 2016-07-27 Tech Partnership The Plc Counting mechanism
JP2020531045A (ja) 2017-07-14 2020-11-05 シートムエックス セラピューティクス，インコーポレイテッド 抗ｃｄ１６６抗体およびその使用
FI3658184T3 (fi) 2017-07-27 2023-11-30 Alexion Pharma Inc Korkean pitoisuuden omaavia anti-c5-vasta-aineformulaatioita
JP7518764B2 (ja) 2017-10-26 2024-07-18 アレクシオン ファーマシューティカルズ， インコーポレイテッド 発作性夜間ヘモグロビン尿症（ＰＮＨ）および非典型溶血性尿毒症症候群（ａＨＵＳ）の処置のための抗Ｃ５抗体の投薬量および投与
DE102018117731A1 (de) 2018-01-16 2019-07-18 F+K Innovationen Gmbh & Co. Kg Vorrichtung zur Dosierung von Flüssigkeit
WO2019231983A1 (en) 2018-05-31 2019-12-05 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients
JP7577542B2 (ja) 2018-06-04 2024-11-05 アレクシオン ファーマシューティカルズ， インコーポレイテッド 小児患者における非典型溶血性尿毒症症候群（ａＨＵＳ）の治療のための抗Ｃ５抗体の用量および投与
JP7538723B2 (ja) 2018-06-28 2024-08-22 アレクシオン ファーマシューティカルズ， インコーポレイテッド 抗ｃ５抗体の産生方法
AU2019370295A1 (en) 2018-10-30 2021-06-03 Alexion Pharmaceuticals, Inc. Subcutaneous dosage and administration of anti-C5 antibodies for treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)
CN113412117B (zh) 2018-12-12 2025-03-04 凯德药业股份有限公司 嵌合抗原和t细胞受体及使用的方法
US11458098B2 (en) 2019-04-29 2022-10-04 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
GB2585205B (en) * 2019-07-01 2021-08-11 Merxin Ltd Ratchet mechanism
CN110559528B (zh) * 2019-10-12 2024-06-07 万通(苏州)定量阀系统有限公司 一种带计数器的气雾剂给药器推钮
KR20230005268A (ko) 2020-04-24 2023-01-09 밀레니엄 파머슈티컬스 인코퍼레이티드 항-cd19 항체 및 이의 용도
US20230277524A1 (en) 2020-05-22 2023-09-07 Trailhead Biosystems Inc. Combination therapy for treatment of viral infections
JP2024515066A (ja) 2021-04-09 2024-04-04 武田薬品工業株式会社 補体因子ｄを標的とする抗体及びその使用
PE20241789A1 (es) 2021-04-26 2024-09-06 Millennium Pharm Inc Anticuerpos anti-clec12a y usos de los mismos
TW202305003A (zh) 2021-04-26 2023-02-01 美商千禧製藥公司 抗adgre2抗體及其用途
MX2024004365A (es) 2021-10-20 2024-04-25 Takeda Pharmaceuticals Co Composiciones que actuan sobre el antigeno de maduracion de linfocitos b (bcma) y metodos de uso de las mismas.
CN114177443B (zh) * 2021-12-31 2025-01-03 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的计数器结构
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
CN120771399B (zh) * 2025-09-11 2025-12-02 苏州嘉树医疗科技有限公司 一种计量指示装置和喷雾器

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2111020C1 (ru) * 1992-12-18 1998-05-20 Шеринг Корпорейшн Ингалятор для порошковых лекарств
FR2721106B1 (fr) * 1994-06-10 1996-09-13 Step Compteur de doses pour inhalateurs.
SE9404140D0 (sv) * 1994-11-29 1994-11-29 Astra Ab Dose indicating device
DE59605366D1 (de) * 1995-12-07 2000-07-06 Jago Pharma Ag Muttenz Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
ES2172763T3 (es) * 1996-02-21 2002-10-01 Schering Corp Inhalador de medicamento en polvo.
FR2799858B1 (fr) * 1999-10-19 2002-01-18 Valois Sa Compteur de doses et distributeur de produit fluide incorporant un tel compteur
SE0100034D0 (sv) * 2001-01-04 2001-01-04 Astrazeneca Ab A delivery device

Also Published As

Publication number Publication date
CN1684731A (zh) 2005-10-19
JP2006500094A (ja) 2006-01-05
AU2003267633A1 (en) 2004-04-08
MXPA05003056A (es) 2005-05-27
KR20050046800A (ko) 2005-05-18
GB0222023D0 (en) 2002-10-30
WO2004026380A3 (en) 2004-08-26
EP1542750B1 (en) 2009-02-25
WO2004026380A2 (en) 2004-04-01
CA2499486A1 (en) 2004-04-01
RU2005111770A (ru) 2006-01-20
RU2323749C2 (ru) 2008-05-10
DE60326366D1 (de) 2009-04-09
ATE423590T1 (de) 2009-03-15
BR0314127A (pt) 2005-07-26
EP1542750A2 (en) 2005-06-22
ZA200502219B (en) 2005-09-16

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