WO2004026380A2 - Inhaler - Google Patents

Inhaler Download PDF

Info

Publication number
WO2004026380A2
WO2004026380A2 PCT/GB2003/004137 GB0304137W WO2004026380A2 WO 2004026380 A2 WO2004026380 A2 WO 2004026380A2 GB 0304137 W GB0304137 W GB 0304137W WO 2004026380 A2 WO2004026380 A2 WO 2004026380A2
Authority
WO
WIPO (PCT)
Prior art keywords
indicator member
wheel
inhaler
air channel
counter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/004137
Other languages
English (en)
French (fr)
Other versions
WO2004026380A3 (en
Inventor
Duncan Grant Young
Simon Paul Wells
Andrew James Ledgeway
Graham Keith Lacy
Julian Francis Ralph Swan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Priority to DE60326366T priority Critical patent/DE60326366D1/de
Priority to JP2004537331A priority patent/JP4612418B2/ja
Priority to CA002499486A priority patent/CA2499486A1/en
Priority to EP03748325A priority patent/EP1542750B1/en
Priority to MXPA05003056A priority patent/MXPA05003056A/es
Priority to AU2003267633A priority patent/AU2003267633A1/en
Priority to BR0314127-6A priority patent/BR0314127A/pt
Publication of WO2004026380A2 publication Critical patent/WO2004026380A2/en
Publication of WO2004026380A3 publication Critical patent/WO2004026380A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/041—Design features of general application for driving the stage of lowest order for drum-type indicating means
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G06M1/163—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism with drums
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/241—Drums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the barrel 18, cover 26, and cap 12 may be polypropylene
  • the tens wheel 34 may be polycarbonate
  • the slave wheel 32 may be polybutylene teraphthalate
  • the unit wheel is preferably polycarbonate
  • the coupling may be polybutylene terephthalate
  • the air channel assembly is predominantly made of an acetal copolymer such as Hostaform ® .
  • the reciprocal rotation of the cap 12 and air channel assembly 14 causes a metered dose of powdered medicament to be scraped from the reservoir 16 and deposited in the air channel assembly 14.
  • the user removes the cap 12, places his or her lips to the mouthpiece 20 and inhales.
  • the medicament becomes entrained in an air stream drawn through the mouthpiece 20 and is drawn into the mouth, trachea and lungs of the user where it is absorbed.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PCT/GB2003/004137 2002-09-21 2003-09-17 Inhaler Ceased WO2004026380A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60326366T DE60326366D1 (de) 2002-09-21 2003-09-17 Inhalator
JP2004537331A JP4612418B2 (ja) 2002-09-21 2003-09-17 吸入器
CA002499486A CA2499486A1 (en) 2002-09-21 2003-09-17 Inhaler
EP03748325A EP1542750B1 (en) 2002-09-21 2003-09-17 Inhaler
MXPA05003056A MXPA05003056A (es) 2002-09-21 2003-09-17 Inhalador.
AU2003267633A AU2003267633A1 (en) 2002-09-21 2003-09-17 Inhaler
BR0314127-6A BR0314127A (pt) 2002-09-21 2003-09-17 Inalador

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0222023.4 2002-09-21
GBGB0222023.4A GB0222023D0 (en) 2002-09-21 2002-09-21 Inhaler

Publications (2)

Publication Number Publication Date
WO2004026380A2 true WO2004026380A2 (en) 2004-04-01
WO2004026380A3 WO2004026380A3 (en) 2004-08-26

Family

ID=9944580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004137 Ceased WO2004026380A2 (en) 2002-09-21 2003-09-17 Inhaler

Country Status (14)

Country Link
EP (1) EP1542750B1 (enExample)
JP (1) JP4612418B2 (enExample)
KR (1) KR20050046800A (enExample)
CN (1) CN1684731A (enExample)
AT (1) ATE423590T1 (enExample)
AU (1) AU2003267633A1 (enExample)
BR (1) BR0314127A (enExample)
CA (1) CA2499486A1 (enExample)
DE (1) DE60326366D1 (enExample)
GB (1) GB0222023D0 (enExample)
MX (1) MXPA05003056A (enExample)
RU (1) RU2323749C2 (enExample)
WO (1) WO2004026380A2 (enExample)
ZA (1) ZA200502219B (enExample)

Cited By (51)

* Cited by examiner, † Cited by third party
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GB2414187A (en) * 2004-05-21 2005-11-23 Bespak Plc A dispensing apparatus having a dosage counter and a cog for use in the counter
EP1616592A1 (en) * 2004-07-16 2006-01-18 Sofotec GmbH & Co. KG Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge for use with this inhaler
GB2429166A (en) * 2005-07-27 2007-02-21 Cambridge Consultants Inhaler counter
WO2007034237A1 (en) 2005-09-20 2007-03-29 Aventis Pharma Limited Mechanical doses counter for a powder inhaler
WO2007077450A3 (en) * 2006-01-04 2007-08-30 42 Technology Ltd Dose counter with an odometer type display
GB2438396A (en) * 2006-05-26 2007-11-28 Bespak Plc Dose counting device
WO2008121670A1 (en) 2007-03-30 2008-10-09 Sanofi-Aventis Pyrimidine hydrazide compounds as pgds inhibitors
JP2009507541A (ja) * 2005-09-09 2009-02-26 クリニカル・デザインズ・リミテッド 薬剤投与装置
EP1779884A4 (en) * 2004-08-12 2009-07-22 Idec Corp CHARGING DEVICE MECHANISM AND LOADING DEVICE HAVING COUNTER-MECHANISM
WO2011044307A1 (en) 2009-10-08 2011-04-14 Sanofi-Aventis Phenyloxadiazole derivatives as pgds inhibitors
WO2011137395A1 (en) 2010-04-30 2011-11-03 Rother Russell P Anti-c5a antibodies and methods for using the antibodies
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8113199B2 (en) 2004-02-16 2012-02-14 Glaxo Group Limited Counter for use with a medicament dispenser
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
US8245906B2 (en) 2006-03-14 2012-08-21 Glaxo Group Limited Counter for use with a medicament dispenser
US8291898B2 (en) 2006-05-26 2012-10-23 Consort Medical Plc Dispensing apparatus
US8479732B2 (en) 2006-04-21 2013-07-09 3M Innovative Properties Company Dose counter
WO2013114371A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dry powder formulations of dnase i
US8511302B2 (en) 2004-04-24 2013-08-20 Innovata Biomed Limited Dose counter mechanisms for medicament delivery devices
US8740014B2 (en) 2003-12-10 2014-06-03 3M Innovative Properties Company Dose counter for dispensers
WO2014160958A1 (en) 2013-03-29 2014-10-02 Alexion Pharmaceuticals, Inc. Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US9079949B1 (en) 2014-03-07 2015-07-14 Alexion Pharmaceuticals, Inc. Anti-C5 antibodies having improved pharmacokinetics
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9125999B2 (en) 2009-05-18 2015-09-08 Adamis Pharmaceuticals Corporation Dry powder inhaler dose counters
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
WO2016113307A1 (en) * 2015-01-13 2016-07-21 Sanofi Sa Assembly for a drug delivery device
US9489615B2 (en) 2012-05-04 2016-11-08 Sanofi Sa Counting mechanism for a drug delivery device and drug delivery device
US9815890B2 (en) 2010-06-22 2017-11-14 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the C3d fragment of complement component 3
WO2017216549A1 (en) * 2016-06-15 2017-12-21 The Technology Partnership Plc Counting mechanism
WO2019014586A1 (en) 2017-07-14 2019-01-17 Cytomx Therapeutics, Inc. ANTI-CD166 ANTIBODIES AND USES THEREOF
US10376218B2 (en) 2010-02-01 2019-08-13 Proteus Digital Health, Inc. Data gathering system
WO2020123691A2 (en) 2018-12-12 2020-06-18 Kite Pharma, Inc Chimeric antigen and t cell receptors and methods of use
WO2020223237A1 (en) 2019-04-29 2020-11-05 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
US10835694B2 (en) 2015-05-08 2020-11-17 Iconovo Ab Dry powder inhaler
WO2021001705A1 (en) * 2019-07-01 2021-01-07 Merxin Ltd Ratchet mechanism
WO2021217024A1 (en) 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof
WO2021237109A1 (en) 2020-05-22 2021-11-25 Trailhead Biosystems Inc. Combination therapy for treatment of viral infections
US11365241B2 (en) 2017-07-27 2022-06-21 Alexion Pharmaceuticals, Inc. High concentration anti-C5 antibody formulations
WO2022215054A1 (en) 2021-04-09 2022-10-13 Takeda Pharmaceutical Company Limited Antibodies targeting complement factor d and uses therof
WO2022232035A1 (en) 2021-04-26 2022-11-03 Millennium Pharmaceuticals, Inc. Anti-adgre2 antibodies and uses thereof
WO2022232044A2 (en) 2021-04-26 2022-11-03 Millennium Pharmaceuticals, Inc. Anti-clec12a antibodies and uses thereof
WO2023068382A2 (en) 2021-10-20 2023-04-27 Takeda Pharmaceutical Company Limited Compositions targeting bcma and methods of use thereof
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
US12128101B2 (en) 2017-10-26 2024-10-29 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)
US12240893B2 (en) 2018-10-30 2025-03-04 Alexion Pharmaceuticals, Inc. Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH)
US12312394B2 (en) 2018-06-28 2025-05-27 Alexion Pharmaceuticals, Inc. Methods of producing anti-C5 antibodies
US12404320B2 (en) 2018-05-31 2025-09-02 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients
US12460012B2 (en) 2018-06-04 2025-11-04 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-C5 antibodies for treatment of atypical hemolytic uremic syndrome (aHUS) in pediatric patients
US12459992B2 (en) 2016-05-27 2025-11-04 Alexion Pharmaceuticals, Inc. Methods for treatment of refractory generalized myasthenia gravis
US12478640B2 (en) 2012-03-07 2025-11-25 Beyond Air Ltd Inhalation of nitric oxide for treating respiratory diseases

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JP5243548B2 (ja) 2007-10-25 2013-07-24 プロテウス デジタル ヘルス， インコーポレイテッド 情報システムのための流体伝達ポート
DK2293833T3 (en) * 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
GB201020130D0 (en) * 2010-11-26 2011-01-12 Vectura Delivery Devices Ltd Inhaler
DE202008017185U1 (de) 2008-12-30 2010-05-12 Siegfried Generics International Ag Dosiervorrichtung
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
GB201118842D0 (en) * 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser cap arrangement
GB201223008D0 (en) * 2012-12-20 2013-01-30 Euro Celtique Sa Counter
RU2544801C2 (ru) * 2013-06-11 2015-03-20 Открытое Акционерное Общество "Фармацевтическая Фабрика Санкт-Петербурга" Порошковый ингалятор
WO2017128170A1 (zh) * 2016-01-28 2017-08-03 扬子江药业集团有限公司 一种储库型干粉吸入器
DK3222314T3 (en) * 2016-03-21 2019-02-25 Joseph Feldman NOSE SPRAY INTERIOR
DE102018117731A1 (de) 2018-01-16 2019-07-18 F+K Innovationen Gmbh & Co. Kg Vorrichtung zur Dosierung von Flüssigkeit
CN110559528B (zh) * 2019-10-12 2024-06-07 万通(苏州)定量阀系统有限公司 一种带计数器的气雾剂给药器推钮
CN114177443B (zh) * 2021-12-31 2025-01-03 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的计数器结构
CN120771399B (zh) * 2025-09-11 2025-12-02 苏州嘉树医疗科技有限公司 一种计量指示装置和喷雾器

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FR2721106B1 (fr) * 1994-06-10 1996-09-13 Step Compteur de doses pour inhalateurs.
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ATE261324T1 (de) * 1995-12-07 2004-03-15 Jago Res Ag Mundstück für einen inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
PL185384B1 (pl) * 1996-02-21 2003-04-30 Schering Corp Inhalator proszku
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Cited By (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8740014B2 (en) 2003-12-10 2014-06-03 3M Innovative Properties Company Dose counter for dispensers
US8113199B2 (en) 2004-02-16 2012-02-14 Glaxo Group Limited Counter for use with a medicament dispenser
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US8511302B2 (en) 2004-04-24 2013-08-20 Innovata Biomed Limited Dose counter mechanisms for medicament delivery devices
GB2414187A (en) * 2004-05-21 2005-11-23 Bespak Plc A dispensing apparatus having a dosage counter and a cog for use in the counter
GB2414187B (en) * 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
US7780038B2 (en) 2004-05-21 2010-08-24 Consort Medical Plc Dispensing apparatus with dosage counter
WO2005113044A1 (en) * 2004-05-21 2005-12-01 Bespak Plc Dispensing apparatus with dosage counter
WO2006008027A1 (en) * 2004-07-16 2006-01-26 Laboratorios Almirall, S.A. Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
EP1616592A1 (en) * 2004-07-16 2006-01-18 Sofotec GmbH & Co. KG Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge for use with this inhaler
AU2005263486B2 (en) * 2004-07-16 2011-05-12 Astrazeneca Ab Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
US8051851B2 (en) 2004-07-16 2011-11-08 Sofotec Gmbh & Co. Kg Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
US7819285B2 (en) 2004-08-12 2010-10-26 Teijin Pharma Limited Counter mechanism of feeding device and feeding device using such counter mechanism
EP1779884A4 (en) * 2004-08-12 2009-07-22 Idec Corp CHARGING DEVICE MECHANISM AND LOADING DEVICE HAVING COUNTER-MECHANISM
GB2429166A (en) * 2005-07-27 2007-02-21 Cambridge Consultants Inhaler counter
JP2009507541A (ja) * 2005-09-09 2009-02-26 クリニカル・デザインズ・リミテッド 薬剤投与装置
US10369307B2 (en) 2005-09-09 2019-08-06 Clinical Designs Limited Dispenser
WO2007034237A1 (en) 2005-09-20 2007-03-29 Aventis Pharma Limited Mechanical doses counter for a powder inhaler
US7827989B2 (en) 2005-09-20 2010-11-09 Aventis Pharma Limited Mechanical doses counter for a powder inhaler
JP2009508614A (ja) * 2005-09-20 2009-03-05 アベンティス・フアーマ・リミテッド 粉末吸入器用の機械的な投与量カウンタ
WO2007077450A3 (en) * 2006-01-04 2007-08-30 42 Technology Ltd Dose counter with an odometer type display
US8245906B2 (en) 2006-03-14 2012-08-21 Glaxo Group Limited Counter for use with a medicament dispenser
US9089661B2 (en) 2006-04-21 2015-07-28 3M Innovative Properties Company Dose counter
US8479732B2 (en) 2006-04-21 2013-07-09 3M Innovative Properties Company Dose counter
EP1860599A3 (en) * 2006-05-26 2013-01-09 Consort Medical Plc Improvements in or relating to dispensing apparatus
US9227028B2 (en) 2006-05-26 2016-01-05 Consort Medical Plc Dispensing apparatus
US8291898B2 (en) 2006-05-26 2012-10-23 Consort Medical Plc Dispensing apparatus
US8689785B2 (en) 2006-05-26 2014-04-08 Consort Medical Plc Dispensing apparatus
GB2438396A (en) * 2006-05-26 2007-11-28 Bespak Plc Dose counting device
GB2438396B (en) * 2006-05-26 2008-10-01 Bespak Plc Improvements in or relating to dispensing apparatus
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US8258130B2 (en) 2007-03-30 2012-09-04 Sanofi Pyrimidine hydrazide compounds as PGDS inhibitors
WO2008121670A1 (en) 2007-03-30 2008-10-09 Sanofi-Aventis Pyrimidine hydrazide compounds as pgds inhibitors
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
US9125999B2 (en) 2009-05-18 2015-09-08 Adamis Pharmaceuticals Corporation Dry powder inhaler dose counters
WO2011044307A1 (en) 2009-10-08 2011-04-14 Sanofi-Aventis Phenyloxadiazole derivatives as pgds inhibitors
US9469627B2 (en) 2009-10-08 2016-10-18 Sanofi Phenyloxadiazole derivatives as PGDS inhibitors
US9937175B2 (en) 2009-10-08 2018-04-10 Sanofi Phenyloxadiazole derivatives as PGDS inhibitors
US10376218B2 (en) 2010-02-01 2019-08-13 Proteus Digital Health, Inc. Data gathering system
US11407821B2 (en) 2010-04-30 2022-08-09 Alexion Pharmaceuticals, Inc. Anti-C5A antibodies
WO2011137395A1 (en) 2010-04-30 2011-11-03 Rother Russell P Anti-c5a antibodies and methods for using the antibodies
US10450370B2 (en) 2010-04-30 2019-10-22 Alexion Pharmaceuticals, Inc. Anti-C5a antibodies
US9221901B2 (en) 2010-04-30 2015-12-29 Alexion Pharmaceuticals, Inc. Methods of treating complement-associated disorders with anti-C5a antibodies
US9963503B2 (en) 2010-04-30 2018-05-08 Alexion Pharmaceuticals, Inc. Methods of producing anti-C5a antibodies
US9309310B2 (en) 2010-04-30 2016-04-12 Alexion Pharmaceuticals, Inc. Nucleic acids encoding anti-C5a antibodies
EP2824111A2 (en) 2010-04-30 2015-01-14 Alexion Pharmaceuticals, Inc. Anti-C5A Antibodies and Methods for Using the Antibodies
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ATE423590T1 (de) 2009-03-15
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RU2005111770A (ru) 2006-01-20
JP2006500094A (ja) 2006-01-05
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