JP4610198B2 - 化学療法剤、化学予防剤、および抗脈管形成剤としての新規なフラバノイドおよびカルコン - Google Patents

化学療法剤、化学予防剤、および抗脈管形成剤としての新規なフラバノイドおよびカルコン Download PDF

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JP4610198B2
JP4610198B2 JP2003586144A JP2003586144A JP4610198B2 JP 4610198 B2 JP4610198 B2 JP 4610198B2 JP 2003586144 A JP2003586144 A JP 2003586144A JP 2003586144 A JP2003586144 A JP 2003586144A JP 4610198 B2 JP4610198 B2 JP 4610198B2
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JP2005533760A5 (enExample
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ヌルライン ザベリ，
ワン−ルー チャオ，
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SRI International Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
JP2003586144A 2002-04-18 2003-04-18 化学療法剤、化学予防剤、および抗脈管形成剤としての新規なフラバノイドおよびカルコン Expired - Fee Related JP4610198B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/126,407 US20030229136A1 (en) 2002-04-18 2002-04-18 Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
PCT/US2003/012658 WO2003089423A2 (en) 2002-04-18 2003-04-18 Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents

Related Child Applications (1)

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JP2010051084A Division JP2010138192A (ja) 2002-04-18 2010-03-08 化学療法剤、化学予防剤、および抗脈管形成剤としての新規なフラバノイドおよびカルコン

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JP2005533760A JP2005533760A (ja) 2005-11-10
JP2005533760A5 JP2005533760A5 (enExample) 2006-04-06
JP4610198B2 true JP4610198B2 (ja) 2011-01-12

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JP2010051084A Withdrawn JP2010138192A (ja) 2002-04-18 2010-03-08 化学療法剤、化学予防剤、および抗脈管形成剤としての新規なフラバノイドおよびカルコン

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US (2) US20030229136A1 (enExample)
EP (1) EP1495014B1 (enExample)
JP (2) JP4610198B2 (enExample)
AT (1) ATE437865T1 (enExample)
AU (1) AU2003231069A1 (enExample)
CA (1) CA2484080C (enExample)
DE (1) DE60328593D1 (enExample)
WO (1) WO2003089423A2 (enExample)

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JP2006298781A (ja) * 2005-04-15 2006-11-02 Geno Membrane:Kk エストロン３硫酸トランスポーター活性阻害剤
WO2011009826A2 (en) 2009-07-21 2011-01-27 ADAMED Sp.z o.o. Novel chalcone derivatives with cytotoxic activity
KR101220417B1 (ko) * 2010-11-04 2013-01-10 건국대학교 산학협력단 세포사멸 유도 활성을 갖는 칼콘 유도체
KR101283004B1 (ko) 2011-10-17 2013-07-05 건국대학교 산학협력단 벤조칼콘을 유효성분으로 포함하는 항암제 조성물
WO2013054998A1 (ko) * 2011-10-13 2013-04-18 건국대학교 산학협력단 신규한 칼콘 유도체 및 이를 유효성분으로 하는 항암제 조성물
KR101424360B1 (ko) * 2012-07-03 2014-08-01 영남대학교 산학협력단 하이드록시 챨콘 화합물을 유효성분으로 함유하는 항암용 조성물
CN102993157B (zh) * 2012-11-21 2015-04-01 上海交通大学 α-萘黄酮衍生物及其制备方法、用途
KR101524770B1 (ko) * 2013-08-29 2015-06-01 건국대학교 산학협력단 세포주기 조절을 통한 항암 효과를 보이는 폴리페놀
CN104059045B (zh) * 2014-05-27 2016-07-06 上海交通大学 水溶性α-萘黄酮醇衍生物及其制备方法、用途
PL233278B1 (pl) * 2017-09-21 2019-09-30 Univ Przyrodniczy We Wroclawiu 5,7,4’-Tripropoksynaringenina i sposób otrzymywania 5,7,4’-tripropoksynaringeniny
PL233579B1 (pl) * 2017-09-21 2019-11-29 Univ Przyrodniczy We Wroclawiu 7-Izopropoksynaringenina, 7,4�-diizopropoksynaringenina i sposob jednoczesnego otrzymywania 7-izopropoksynaringeniny oraz 7,4�-diizopropoksynaringeniny
CN108670966A (zh) * 2018-07-10 2018-10-19 浙江工业大学 二氢吡喃酮类化合物在制备抗肿瘤药物中的应用
CN108904491A (zh) * 2018-07-10 2018-11-30 浙江工业大学 一种黄烷酮类化合物在制备抗肿瘤药物中的应用
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

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ATE437865T1 (de) 2009-08-15
AU2003231069A1 (en) 2003-11-03
US20030229136A1 (en) 2003-12-11
US20040029914A1 (en) 2004-02-12
US7329687B2 (en) 2008-02-12
WO2003089423A3 (en) 2004-02-19
DE60328593D1 (en) 2009-09-10
AU2003231069A8 (en) 2003-11-03
EP1495014B1 (en) 2009-07-29
JP2010138192A (ja) 2010-06-24
WO2003089423A2 (en) 2003-10-30
CA2484080C (en) 2011-06-14
EP1495014A2 (en) 2005-01-12
JP2005533760A (ja) 2005-11-10
CA2484080A1 (en) 2003-10-30

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