AU2003231069A1 - Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents - Google Patents

Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents

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Publication number
AU2003231069A1
AU2003231069A1 AU2003231069A AU2003231069A AU2003231069A1 AU 2003231069 A1 AU2003231069 A1 AU 2003231069A1 AU 2003231069 A AU2003231069 A AU 2003231069A AU 2003231069 A AU2003231069 A AU 2003231069A AU 2003231069 A1 AU2003231069 A1 AU 2003231069A1
Authority
AU
Australia
Prior art keywords
sup
sub
alpha
chalcones
chemopreventive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003231069A
Other languages
English (en)
Other versions
AU2003231069A8 (en
Inventor
Wan-Ru Chao
Nurulain Zaveri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of AU2003231069A1 publication Critical patent/AU2003231069A1/en
Publication of AU2003231069A8 publication Critical patent/AU2003231069A8/xx
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
AU2003231069A 2002-04-18 2003-04-18 Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents Abandoned AU2003231069A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/126,407 2002-04-18
US10/126,407 US20030229136A1 (en) 2002-04-18 2002-04-18 Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
PCT/US2003/012658 WO2003089423A2 (en) 2002-04-18 2003-04-18 Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents

Publications (2)

Publication Number Publication Date
AU2003231069A1 true AU2003231069A1 (en) 2003-11-03
AU2003231069A8 AU2003231069A8 (en) 2003-11-03

Family

ID=29248416

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003231069A Abandoned AU2003231069A1 (en) 2002-04-18 2003-04-18 Novel flavanoids and chalcones as chemotherapeutic, chemopreventive, and antiangiogenic agents

Country Status (8)

Country Link
US (2) US20030229136A1 (enExample)
EP (1) EP1495014B1 (enExample)
JP (2) JP4610198B2 (enExample)
AT (1) ATE437865T1 (enExample)
AU (1) AU2003231069A1 (enExample)
CA (1) CA2484080C (enExample)
DE (1) DE60328593D1 (enExample)
WO (1) WO2003089423A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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JP2006298781A (ja) * 2005-04-15 2006-11-02 Geno Membrane:Kk エストロン３硫酸トランスポーター活性阻害剤
WO2011009826A2 (en) 2009-07-21 2011-01-27 ADAMED Sp.z o.o. Novel chalcone derivatives with cytotoxic activity
KR101220417B1 (ko) * 2010-11-04 2013-01-10 건국대학교 산학협력단 세포사멸 유도 활성을 갖는 칼콘 유도체
KR101283004B1 (ko) 2011-10-17 2013-07-05 건국대학교 산학협력단 벤조칼콘을 유효성분으로 포함하는 항암제 조성물
WO2013054998A1 (ko) * 2011-10-13 2013-04-18 건국대학교 산학협력단 신규한 칼콘 유도체 및 이를 유효성분으로 하는 항암제 조성물
KR101424360B1 (ko) * 2012-07-03 2014-08-01 영남대학교 산학협력단 하이드록시 챨콘 화합물을 유효성분으로 함유하는 항암용 조성물
CN102993157B (zh) * 2012-11-21 2015-04-01 上海交通大学 α-萘黄酮衍生物及其制备方法、用途
KR101524770B1 (ko) * 2013-08-29 2015-06-01 건국대학교 산학협력단 세포주기 조절을 통한 항암 효과를 보이는 폴리페놀
CN104059045B (zh) * 2014-05-27 2016-07-06 上海交通大学 水溶性α-萘黄酮醇衍生物及其制备方法、用途
PL233278B1 (pl) * 2017-09-21 2019-09-30 Univ Przyrodniczy We Wroclawiu 5,7,4’-Tripropoksynaringenina i sposób otrzymywania 5,7,4’-tripropoksynaringeniny
PL233579B1 (pl) * 2017-09-21 2019-11-29 Univ Przyrodniczy We Wroclawiu 7-Izopropoksynaringenina, 7,4�-diizopropoksynaringenina i sposob jednoczesnego otrzymywania 7-izopropoksynaringeniny oraz 7,4�-diizopropoksynaringeniny
CN108670966A (zh) * 2018-07-10 2018-10-19 浙江工业大学 二氢吡喃酮类化合物在制备抗肿瘤药物中的应用
CN108904491A (zh) * 2018-07-10 2018-11-30 浙江工业大学 一种黄烷酮类化合物在制备抗肿瘤药物中的应用
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

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BE787838R (fr) * 1971-08-25 1973-02-22 Delalande Sa Nouveaux derives du cinnamoyl-5 benzofuranne, leur procede de preparation et leur utilisation en therapeutique
JPH0617304B2 (ja) * 1982-09-09 1994-03-09 理化学研究所 制癌剤
USH1427H (en) 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
KR0139296B1 (ko) 1988-11-21 1998-05-15 가와무라 시게꾸니 칼콘 유도체 및 그 제조 방법
JPH0725761A (ja) 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd 軟骨保護剤
ATE286038T1 (de) * 1996-03-05 2005-01-15 Sterix Ltd Verbindungen mit sulfonsäure-amidgruppe
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
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FR2781153B1 (fr) * 1998-07-15 2001-08-03 Lafon Labor Composition therapeutique a base de flavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques
US5961892A (en) * 1998-09-11 1999-10-05 Ppg Industries Ohio, Inc. Polyalkoxylated naphthopyrans
JP2003504327A (ja) 1999-07-08 2003-02-04 プレンダーガスト、パトリック、ティ． 感染症の治療を目的としたフラボン類、クマリン類および関連化合物の使用
GB9920910D0 (en) * 1999-09-03 1999-11-10 Indena Spa Novel chalcones
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JP4813652B2 (ja) * 2000-12-04 2011-11-09 丸善製薬株式会社 マトリックスメタロプロテアーゼ阻害剤
KR100472694B1 (ko) * 2000-12-30 2005-03-07 한국생명공학연구원 플라바논 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물
US20020160983A1 (en) * 2001-03-16 2002-10-31 Alberto Bargiotti Substituted benzopyranones as telomerase inhibitors

Also Published As

Publication number Publication date
ATE437865T1 (de) 2009-08-15
US20030229136A1 (en) 2003-12-11
US20040029914A1 (en) 2004-02-12
US7329687B2 (en) 2008-02-12
WO2003089423A3 (en) 2004-02-19
DE60328593D1 (en) 2009-09-10
AU2003231069A8 (en) 2003-11-03
EP1495014B1 (en) 2009-07-29
JP2010138192A (ja) 2010-06-24
WO2003089423A2 (en) 2003-10-30
CA2484080C (en) 2011-06-14
EP1495014A2 (en) 2005-01-12
JP2005533760A (ja) 2005-11-10
JP4610198B2 (ja) 2011-01-12
CA2484080A1 (en) 2003-10-30

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