JP4580608B2 - 微小流体デバイス表面 - Google Patents
微小流体デバイス表面 Download PDFInfo
- Publication number
- JP4580608B2 JP4580608B2 JP2001548220A JP2001548220A JP4580608B2 JP 4580608 B2 JP4580608 B2 JP 4580608B2 JP 2001548220 A JP2001548220 A JP 2001548220A JP 2001548220 A JP2001548220 A JP 2001548220A JP 4580608 B2 JP4580608 B2 JP 4580608B2
- Authority
- JP
- Japan
- Prior art keywords
- microfluidic device
- cavity
- use according
- microchannel
- functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 36
- 229920000642 polymer Polymers 0.000 claims abstract description 36
- 239000007788 liquid Substances 0.000 claims description 31
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 229920003023 plastic Polymers 0.000 claims description 18
- 239000004033 plastic Substances 0.000 claims description 18
- 239000000178 monomer Substances 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- 229920002873 Polyethylenimine Polymers 0.000 claims description 12
- -1 polyoxyethylene chain Polymers 0.000 claims description 12
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229920000768 polyamine Polymers 0.000 claims description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 7
- 238000006116 polymerization reaction Methods 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 125000000524 functional group Chemical group 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- 230000003647 oxidation Effects 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 238000009832 plasma treatment Methods 0.000 claims description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 125000003368 amide group Chemical group 0.000 claims description 2
- 230000009881 electrostatic interaction Effects 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 238000007334 copolymerization reaction Methods 0.000 claims 1
- SBNKFTQSBPKMBZ-UHFFFAOYSA-N ethenzamide Chemical compound CCOC1=CC=CC=C1C(N)=O SBNKFTQSBPKMBZ-UHFFFAOYSA-N 0.000 claims 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 125000002947 alkylene group Chemical group 0.000 description 8
- 239000011888 foil Substances 0.000 description 8
- 238000003556 assay Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 229920000515 polycarbonate Polymers 0.000 description 7
- 239000004417 polycarbonate Substances 0.000 description 7
- 229920000139 polyethylene terephthalate Polymers 0.000 description 7
- 239000005020 polyethylene terephthalate Substances 0.000 description 7
- 230000032258 transport Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 229920002379 silicone rubber Polymers 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 229920002401 polyacrylamide Polymers 0.000 description 5
- 239000000376 reactant Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 239000012491 analyte Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 4
- 238000005251 capillar electrophoresis Methods 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 239000011147 inorganic material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000011368 organic material Substances 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005661 hydrophobic surface Effects 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 229910052814 silicon oxide Inorganic materials 0.000 description 3
- 239000004945 silicone rubber Substances 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229920004482 WACKER® Polymers 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 229920003086 cellulose ether Polymers 0.000 description 2
- 150000001925 cycloalkenes Chemical class 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000005370 electroosmosis Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 230000005660 hydrophilic surface Effects 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000004381 surface treatment Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- QNODIIQQMGDSEF-UHFFFAOYSA-N (1-hydroxycyclohexyl)-phenylmethanone Chemical compound C=1C=CC=CC=1C(=O)C1(O)CCCCC1 QNODIIQQMGDSEF-UHFFFAOYSA-N 0.000 description 1
- WVAFEFUPWRPQSY-UHFFFAOYSA-N 1,2,3-tris(ethenyl)benzene Chemical compound C=CC1=CC=CC(C=C)=C1C=C WVAFEFUPWRPQSY-UHFFFAOYSA-N 0.000 description 1
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 229920004011 Macrolon® Polymers 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000000026 X-ray photoelectron spectrum Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000005529 alkyleneoxy group Chemical group 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 150000002118 epoxides Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 1
- 150000002848 norbornenes Chemical class 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003512 tertiary amines Chemical group 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Photolithography (AREA)
- Laminated Bodies (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904802-7 | 1999-12-23 | ||
| SE9904802A SE9904802D0 (sv) | 1999-12-23 | 1999-12-23 | Microfluidic surfaces |
| PCT/EP2000/012478 WO2001047637A1 (en) | 1999-12-23 | 2000-12-11 | Microfluidic surfaces |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003518610A JP2003518610A (ja) | 2003-06-10 |
| JP2003518610A5 JP2003518610A5 (enExample) | 2010-09-16 |
| JP4580608B2 true JP4580608B2 (ja) | 2010-11-17 |
Family
ID=20418324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001548220A Expired - Lifetime JP4580608B2 (ja) | 1999-12-23 | 2000-12-11 | 微小流体デバイス表面 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7955575B2 (enExample) |
| EP (1) | EP1255610B1 (enExample) |
| JP (1) | JP4580608B2 (enExample) |
| AT (1) | ATE320310T1 (enExample) |
| AU (1) | AU2166001A (enExample) |
| DE (1) | DE60026736T2 (enExample) |
| ES (1) | ES2260083T3 (enExample) |
| SE (1) | SE9904802D0 (enExample) |
| WO (1) | WO2001047637A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
| GB9809943D0 (en) | 1998-05-08 | 1998-07-08 | Amersham Pharm Biotech Ab | Microfluidic device |
| US7261859B2 (en) | 1998-12-30 | 2007-08-28 | Gyros Ab | Microanalysis device |
| SE9902474D0 (sv) | 1999-06-30 | 1999-06-30 | Amersham Pharm Biotech Ab | Polymer valves |
| SE9904802D0 (sv) | 1999-12-23 | 1999-12-23 | Amersham Pharm Biotech Ab | Microfluidic surfaces |
| SE0001790D0 (sv) * | 2000-05-12 | 2000-05-12 | Aamic Ab | Hydrophobic barrier |
| SE0004296D0 (sv) * | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| US7054258B2 (en) | 2000-12-08 | 2006-05-30 | Nagaoka & Co., Ltd. | Optical disc assemblies for performing assays |
| WO2002046721A2 (en) | 2000-12-08 | 2002-06-13 | Burstein Technologies, Inc. | Optical discs for measuring analytes |
| US7091034B2 (en) | 2000-12-15 | 2006-08-15 | Burstein Technologies, Inc. | Detection system for disk-based laboratory and improved optical bio-disc including same |
| US6653625B2 (en) | 2001-03-19 | 2003-11-25 | Gyros Ab | Microfluidic system (MS) |
| US6717136B2 (en) | 2001-03-19 | 2004-04-06 | Gyros Ab | Microfludic system (EDI) |
| WO2002075312A1 (en) | 2001-03-19 | 2002-09-26 | Gyros Ab | Characterization of reaction variables |
| CA2442342A1 (en) | 2001-03-19 | 2002-09-26 | Gyros Ab | A microfluidic system (edi) |
| US7429354B2 (en) | 2001-03-19 | 2008-09-30 | Gyros Patent Ab | Structural units that define fluidic functions |
| US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
| WO2003018198A1 (en) | 2001-08-28 | 2003-03-06 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
| US7189368B2 (en) | 2001-09-17 | 2007-03-13 | Gyros Patent Ab | Functional unit enabling controlled flow in a microfluidic device |
| JP2003159526A (ja) * | 2001-11-28 | 2003-06-03 | Takashi Inaga | 化学マイクロデバイス |
| US6532997B1 (en) | 2001-12-28 | 2003-03-18 | 3M Innovative Properties Company | Sample processing device with integral electrophoresis channels |
| WO2003082730A1 (en) * | 2002-03-31 | 2003-10-09 | Gyros Ab | Efficient mmicrofluidic devices |
| WO2003086960A1 (en) * | 2002-04-09 | 2003-10-23 | Gyros Ab | Microfluidic devices with new inner surfaces |
| US6955738B2 (en) | 2002-04-09 | 2005-10-18 | Gyros Ab | Microfluidic devices with new inner surfaces |
| US7041258B2 (en) | 2002-07-26 | 2006-05-09 | Applera Corporation | Micro-channel design features that facilitate centripetal fluid transfer |
| US7431888B2 (en) * | 2002-09-20 | 2008-10-07 | The Regents Of The University Of California | Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices |
| US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| JP4009683B2 (ja) * | 2002-09-26 | 2007-11-21 | アークレイ株式会社 | 分析用具の製造方法 |
| WO2004067444A1 (en) | 2003-01-30 | 2004-08-12 | Gyros Ab | Inner walls of microfluidic devices |
| SE0300823D0 (sv) | 2003-03-23 | 2003-03-23 | Gyros Ab | Preloaded Microscale Devices |
| SE0300822D0 (sv) * | 2003-03-23 | 2003-03-23 | Gyros Ab | A collection of Micro Scale Devices |
| JP2007502428A (ja) | 2003-05-23 | 2007-02-08 | ユィロス・パテント・アクチボラグ | 非湿潤性表面に基づく流体機能 |
| US20060246526A1 (en) * | 2003-06-02 | 2006-11-02 | Gyros Patent Ab | Microfluidic affinity assays with improved performance |
| US7238269B2 (en) | 2003-07-01 | 2007-07-03 | 3M Innovative Properties Company | Sample processing device with unvented channel |
| SE0400007D0 (sv) * | 2004-01-02 | 2004-01-02 | Gyros Ab | Large scale surface modifiv´cation of microfluidic devices |
| JP2007524849A (ja) * | 2004-01-06 | 2007-08-30 | ユィロス・パテント・アクチボラグ | 接触加熱アレンジメント |
| US20090010819A1 (en) * | 2004-01-17 | 2009-01-08 | Gyros Patent Ab | Versatile flow path |
| SE0400181D0 (sv) * | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| DE102004005337A1 (de) * | 2004-02-04 | 2005-08-25 | Studiengesellschaft Kohle Mbh | Mikrofluidische Chips mit immanenten hydrophilen Oberflächen |
| DE102004009012A1 (de) * | 2004-02-25 | 2005-09-15 | Roche Diagnostics Gmbh | Testelement mit einer Kapillare zum Transport einer flüssigen Probe |
| JP2006071433A (ja) * | 2004-09-01 | 2006-03-16 | Shimadzu Corp | 電気泳動方法、電気泳動媒体及び被覆材 |
| US20060147344A1 (en) * | 2004-09-30 | 2006-07-06 | The University Of Cincinnati | Fully packed capillary electrophoretic separation microchips with self-assembled silica colloidal particles in microchannels and their preparation methods |
| SE0403139D0 (sv) * | 2004-12-23 | 2004-12-23 | Nanoxis Ab | Device and use thereof |
| EP1849004A1 (en) * | 2005-01-17 | 2007-10-31 | Gyros Patent Ab | A versatile flow path |
| KR101198038B1 (ko) | 2005-01-28 | 2012-11-06 | 듀크 유니버서티 | 인쇄 회로 기판 위의 액적 조작을 위한 기구 및 방법 |
| US7947235B2 (en) | 2005-04-14 | 2011-05-24 | Gyros Ab | Microfluidic device with finger valves |
| CN101237934B (zh) * | 2005-05-21 | 2012-12-19 | 先进液体逻辑公司 | 用亲水性聚合物助剂减弱生物分子的吸附 |
| EP2032984A1 (en) | 2005-12-12 | 2009-03-11 | Gyros Patent Ab | Microfluidic assays and microfluidic devices |
| US20070134739A1 (en) * | 2005-12-12 | 2007-06-14 | Gyros Patent Ab | Microfluidic assays and microfluidic devices |
| US20070139451A1 (en) * | 2005-12-20 | 2007-06-21 | Somasiri Nanayakkara L | Microfluidic device having hydrophilic microchannels |
| US8613889B2 (en) * | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
| US8492168B2 (en) * | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US8637317B2 (en) * | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
| US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US7851184B2 (en) | 2006-04-18 | 2010-12-14 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification method and apparatus |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| EP1887355B1 (de) * | 2006-08-02 | 2017-09-27 | F. Hoffmann-La Roche AG | Beschichtungsverfahren für ein mikrofluidiksystem. |
| EP2077912B1 (en) * | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| SE0700424L (sv) | 2007-02-21 | 2008-05-20 | Gyros Patent Ab | Förfarande för blandning av alikvoter i en mikrokanalstruktur |
| BRPI0814075A2 (pt) * | 2007-07-17 | 2015-02-03 | Basf Se | Processo para separar pelo menos um material hidrofóbico de uma mistura, e, uso de uma superfície sólida, hidrofóbica |
| US8268246B2 (en) | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| US20110306120A1 (en) | 2008-07-15 | 2011-12-15 | L3 Technology Limited | Assay device and methods |
| WO2010115454A1 (en) | 2009-04-06 | 2010-10-14 | Trinean Nv | Sample storage in microfluidics devices |
| GB0912509D0 (en) * | 2009-07-17 | 2009-08-26 | Norchip As | A microfabricated device for metering an analyte |
| CA2776942A1 (en) * | 2009-10-22 | 2011-04-28 | Ge Healthcare Bio-Sciences Ab | Cell culture/handling product and method for production and use thereof |
| EP2409766A1 (de) | 2010-07-23 | 2012-01-25 | F. Hoffmann-La Roche AG | Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile |
| WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
| WO2013064754A1 (fr) | 2011-09-15 | 2013-05-10 | Parmentier Francois | Monolithe multicapillaire en silice amorphe et/ou en alumine activee |
| WO2015019522A1 (ja) | 2013-08-08 | 2015-02-12 | パナソニック株式会社 | 核酸増幅デバイス、核酸増幅装置及び核酸増幅方法 |
| US9993819B2 (en) | 2014-12-30 | 2018-06-12 | Stmicroelectronics S.R.L. | Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus |
| US10545117B2 (en) * | 2015-01-15 | 2020-01-28 | Arkray, Inc. | Sample analysis method and solution therefor |
| US9604209B2 (en) | 2015-03-19 | 2017-03-28 | International Business Machines Corporation | Microfluidic device with anti-wetting, venting areas |
| KR102012242B1 (ko) | 2017-09-18 | 2019-08-21 | 한국기계연구원 | 미소유체소자용 커버, 상기 커버의 제작 방법 및 상기 커버를 가지는 미소유체소자 |
| US12031982B2 (en) * | 2020-04-19 | 2024-07-09 | John J. Daniels | Using exhaled breath condensate for testing for a biomarker of COVID-19 |
| US12369816B2 (en) | 2020-04-19 | 2025-07-29 | John J. Daniels | Mask-based diagnostic system using exhaled breath condensate |
| US12442726B2 (en) | 2020-04-19 | 2025-10-14 | John J. Daniels | Mask-based testing system for detecting biomarkers in exhaled breath condensate, aerosols and gases |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489470A (en) | 1974-07-04 | 1977-10-19 | Showa Denko Kk | Norbornene polymers |
| US4680201A (en) | 1985-10-30 | 1987-07-14 | Stellan Hjerten | Coating for electrophoresis tube |
| US4690749A (en) | 1985-12-16 | 1987-09-01 | Universities Space Research Association | Polymer-coated surfaces to control surface zeta potential |
| JPH03223674A (ja) * | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | 反応容器 |
| AU642444B2 (en) | 1989-11-30 | 1993-10-21 | Mochida Pharmaceutical Co., Ltd. | Reaction vessel |
| GB2238791A (en) | 1989-12-06 | 1991-06-12 | Shell Int Research | Process for polymerizing oxanorbornenes and polymers obtainable by the process |
| US5126022A (en) * | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US6054034A (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
| SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
| GB2244276A (en) | 1990-05-21 | 1991-11-27 | Ici Plc | Amorphous polyolefins |
| JP3063769B2 (ja) | 1990-07-17 | 2000-07-12 | イーシー化学株式会社 | 大気圧プラズマ表面処理法 |
| SE467309B (sv) * | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | Hydrofiliserad fast yta, foerfarande foer dess framstaellning samt medel daerfoer |
| SE467308B (sv) * | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer |
| JP3382632B2 (ja) | 1992-03-13 | 2003-03-04 | オリンパス光学工業株式会社 | 生体関連物質の測定方法およびそれに用いる反応容器 |
| US5958202A (en) * | 1992-09-14 | 1999-09-28 | Perseptive Biosystems, Inc. | Capillary electrophoresis enzyme immunoassay |
| SE508435C2 (sv) | 1993-02-23 | 1998-10-05 | Erik Stemme | Förträngningspump av membranpumptyp |
| SE501380C2 (sv) | 1993-06-15 | 1995-01-30 | Pharmacia Lkb Biotech | Sätt att tillverka mikrokanal/mikrokavitetsstrukturer |
| SE9304145D0 (sv) | 1993-12-10 | 1993-12-10 | Pharmacia Lkb Biotech | Sätt att tillverka hålrumsstrukturer |
| SE9401327D0 (sv) | 1994-04-20 | 1994-04-20 | Pharmacia Lkb Biotech | Hydrofilisering av hydrofob polymer |
| US5700559A (en) | 1994-12-16 | 1997-12-23 | Advanced Surface Technology | Durable hydrophilic surface coatings |
| JP4026724B2 (ja) | 1995-01-27 | 2007-12-26 | ノースイースタン ユニバーシティー | 毛管電気泳動のためのポリビニルアルコール（ｐｖａ）をベースとする共有結合の安定した親水性コーティング |
| US5995209A (en) | 1995-04-27 | 1999-11-30 | Pharmacia Biotech Ab | Apparatus for continuously measuring physical and chemical parameters in a fluid flow |
| SE9502251D0 (sv) | 1995-06-21 | 1995-06-21 | Pharmacia Ab | Flow-through sampling cell and use thereof |
| SE9502258D0 (sv) | 1995-06-21 | 1995-06-21 | Pharmacia Biotech Ab | Method for the manufacture of a membrane-containing microstructure |
| KR100306951B1 (ko) | 1995-12-05 | 2001-11-15 | 테칸 보스턴, 인코포레이티드 | 내장된정보과학에의해미세유체공학시스템내의유체유동을구동시키기위해구심가속도를이용하는장치및방법 |
| US6144447A (en) | 1996-04-25 | 2000-11-07 | Pharmacia Biotech Ab | Apparatus for continuously measuring physical and chemical parameters in a fluid flow |
| WO1997047390A1 (en) | 1996-06-14 | 1997-12-18 | University Of Washington | Absorption-enhanced differential extraction device |
| SE9602638D0 (sv) | 1996-07-03 | 1996-07-03 | Pharmacia Biotech Ab | An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds |
| AT404099B (de) | 1996-12-18 | 1998-08-25 | Buchmeiser Michael Rudolf Mag | Polymeres trennmaterial |
| US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| JP4303793B2 (ja) | 1997-06-02 | 2009-07-29 | オーロラ バイオサイエンシズ コーポレーション | 生物学的および生化学的サンプルの蛍光測定用低バックグラウンドマルチウェルプレート |
| US6803019B1 (en) | 1997-10-15 | 2004-10-12 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| EP0914926B1 (en) * | 1997-11-07 | 2002-09-11 | Rohm And Haas Company | Process and apparatus for forming plastic sheet |
| DE19753847A1 (de) * | 1997-12-04 | 1999-06-10 | Roche Diagnostics Gmbh | Analytisches Testelement mit Kapillarkanal |
| DE19753897A1 (de) | 1997-12-05 | 1999-06-10 | Thomson Brandt Gmbh | Kraftübertragungssystem mit einem Zahnrad und einer Zahnstange |
| US6027695A (en) | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
| GB9808836D0 (en) | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
| US20040202579A1 (en) | 1998-05-08 | 2004-10-14 | Anders Larsson | Microfluidic device |
| GB9809943D0 (en) | 1998-05-08 | 1998-07-08 | Amersham Pharm Biotech Ab | Microfluidic device |
| JP4074713B2 (ja) * | 1998-07-29 | 2008-04-09 | 財団法人川村理化学研究所 | 送液デバイス及びその製造方法 |
| DE69911802T2 (de) | 1998-10-14 | 2004-07-29 | Gyros Ab | Form und verfahren zu deren herstellung |
| US6326083B1 (en) | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety |
| DE19938002A1 (de) * | 1999-08-11 | 2001-02-15 | Studiengesellschaft Kohle Mbh | Beschichtung mit quervernetzten hydrophilen Polymeren |
| US6410668B1 (en) * | 1999-08-21 | 2002-06-25 | Marcella Chiari | Robust polymer coating |
| SE9903011D0 (sv) | 1999-08-26 | 1999-08-26 | Aamic Ab | Sätt att framställa en plastprodukt och ett härför utnyttjat plastproduktformande arrangemang |
| SE9904802D0 (sv) | 1999-12-23 | 1999-12-23 | Amersham Pharm Biotech Ab | Microfluidic surfaces |
| US6884395B2 (en) | 2000-05-12 | 2005-04-26 | Gyros Ab | Integrated microfluidic disc |
| SE0001790D0 (sv) | 2000-05-12 | 2000-05-12 | Aamic Ab | Hydrophobic barrier |
| SE0004296D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| SE0004297D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device for thermal cycling |
| US20040099310A1 (en) | 2001-01-05 | 2004-05-27 | Per Andersson | Microfluidic device |
| US6653625B2 (en) | 2001-03-19 | 2003-11-25 | Gyros Ab | Microfluidic system (MS) |
| US7038988B2 (en) * | 2001-01-25 | 2006-05-02 | Dphi Acquisitions, Inc. | System and method for controlling time critical operations in a control system for an optical disc drive |
| US7429354B2 (en) | 2001-03-19 | 2008-09-30 | Gyros Patent Ab | Structural units that define fluidic functions |
| CA2442342A1 (en) | 2001-03-19 | 2002-09-26 | Gyros Ab | A microfluidic system (edi) |
| US6717136B2 (en) | 2001-03-19 | 2004-04-06 | Gyros Ab | Microfludic system (EDI) |
| WO2002075312A1 (en) | 2001-03-19 | 2002-09-26 | Gyros Ab | Characterization of reaction variables |
| SE0104077D0 (sv) | 2001-10-21 | 2001-12-05 | Gyros Ab | A method and instrumentation for micro dispensation of droplets |
| US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
| US20030054563A1 (en) | 2001-09-17 | 2003-03-20 | Gyros Ab | Detector arrangement for microfluidic devices |
| SE0103109D0 (sv) | 2001-09-17 | 2001-09-17 | Gyros Microlabs Ab | Detector arrangement with rotary drive in an instrument for analysis of microscale liquid sample volumes |
| US7189368B2 (en) | 2001-09-17 | 2007-03-13 | Gyros Patent Ab | Functional unit enabling controlled flow in a microfluidic device |
| US6728644B2 (en) | 2001-09-17 | 2004-04-27 | Gyros Ab | Method editor |
| US7238255B2 (en) | 2001-12-31 | 2007-07-03 | Gyros Patent Ab | Microfluidic device and its manufacture |
| US7221783B2 (en) | 2001-12-31 | 2007-05-22 | Gyros Patent Ab | Method and arrangement for reducing noise |
| WO2003082730A1 (en) | 2002-03-31 | 2003-10-09 | Gyros Ab | Efficient mmicrofluidic devices |
| JP4338529B2 (ja) | 2002-04-08 | 2009-10-07 | ユロス・パテント・アクチボラゲット | ホーミングプロセス |
| US6955738B2 (en) | 2002-04-09 | 2005-10-18 | Gyros Ab | Microfluidic devices with new inner surfaces |
| US8592219B2 (en) | 2005-01-17 | 2013-11-26 | Gyros Patent Ab | Protecting agent |
-
1999
- 1999-12-23 SE SE9904802A patent/SE9904802D0/xx unknown
-
2000
- 2000-12-11 AT AT00985154T patent/ATE320310T1/de not_active IP Right Cessation
- 2000-12-11 DE DE60026736T patent/DE60026736T2/de not_active Expired - Lifetime
- 2000-12-11 EP EP00985154A patent/EP1255610B1/en not_active Expired - Lifetime
- 2000-12-11 JP JP2001548220A patent/JP4580608B2/ja not_active Expired - Lifetime
- 2000-12-11 US US10/069,827 patent/US7955575B2/en active Active
- 2000-12-11 ES ES00985154T patent/ES2260083T3/es not_active Expired - Lifetime
- 2000-12-11 WO PCT/EP2000/012478 patent/WO2001047637A1/en not_active Ceased
- 2000-12-11 AU AU21660/01A patent/AU2166001A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1255610B1 (en) | 2006-03-15 |
| US20020125135A1 (en) | 2002-09-12 |
| WO2001047637A1 (en) | 2001-07-05 |
| EP1255610A1 (en) | 2002-11-13 |
| JP2003518610A (ja) | 2003-06-10 |
| SE9904802D0 (sv) | 1999-12-23 |
| AU2166001A (en) | 2001-07-09 |
| US7955575B2 (en) | 2011-06-07 |
| ATE320310T1 (de) | 2006-04-15 |
| DE60026736D1 (de) | 2006-05-11 |
| DE60026736T2 (de) | 2006-11-09 |
| ES2260083T3 (es) | 2006-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4580608B2 (ja) | 微小流体デバイス表面 | |
| AU2002211894B2 (en) | Surface adsorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces | |
| US6509059B2 (en) | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety | |
| US7597932B2 (en) | Mesoporous permeation layers for use on active electronic matrix devices | |
| US8444934B2 (en) | Removable microfluidic flow cell | |
| Popat et al. | Poly (ethylene glycol) interfaces: an approach for enhanced performance of microfluidic systems | |
| EP2905304B1 (en) | Encoded polymer microparticles | |
| AU2002211894A1 (en) | Surface adsorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces | |
| US20030104391A1 (en) | Solid-phase chemical analysis using array hybridization facilitated by agitation during certrifuging | |
| JP2005524058A (ja) | 生体分子および細胞を固定化するためのポリマーでコーティングされた基質 | |
| US20050123454A1 (en) | Microfluidic device and material manipulating method using same | |
| CN108291910B (zh) | 用于数字计数的流动系统和方法 | |
| JP2006519100A (ja) | 微小流動性デバイスの内部の壁 | |
| WO2017205876A1 (en) | Methods and apparatus for coated flowcells | |
| WO2005003769A1 (ja) | バイオチップ | |
| EP3558510B1 (en) | Array including sequencing primer and non-sequencing entity | |
| US20040157320A1 (en) | Low fluorescence nylon/glass composites for micro-analytical diagnostic applications | |
| Xu et al. | Phospholipid polymer biointerfaces for lab-on-a-chip devices | |
| WO2009100462A2 (en) | Polymer surface functionalization and related applications | |
| US8962301B2 (en) | Biochip and method for manufacturing the same | |
| US20070031862A1 (en) | Preparation of plastic supports for biochips | |
| KR20120038352A (ko) | 바이오 칩 및 이의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20051128 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071120 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071120 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20091221 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100105 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100107 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100115 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20100705 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100824 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100830 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130903 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4580608 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |