JP4574619B2 - 肝細胞癌の検査及び監視 - Google Patents

肝細胞癌の検査及び監視 Download PDF

Info

Publication number
JP4574619B2
JP4574619B2 JP2006525478A JP2006525478A JP4574619B2 JP 4574619 B2 JP4574619 B2 JP 4574619B2 JP 2006525478 A JP2006525478 A JP 2006525478A JP 2006525478 A JP2006525478 A JP 2006525478A JP 4574619 B2 JP4574619 B2 JP 4574619B2
Authority
JP
Japan
Prior art keywords
serum
hcc
hcv
subject
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006525478A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007506945A (ja
JP2007506945A5 (enExample
Inventor
アール ロマーノ パトリック
エム．ブロック ティモシー
ジェイ．フィンメル クラウス
ニコラエバ オルガ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of JP2007506945A publication Critical patent/JP2007506945A/ja
Publication of JP2007506945A5 publication Critical patent/JP2007506945A5/ja
Application granted granted Critical
Publication of JP4574619B2 publication Critical patent/JP4574619B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2006525478A 2003-09-05 2004-09-03 肝細胞癌の検査及び監視 Expired - Fee Related JP4574619B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50065703P 2003-09-05 2003-09-05
PCT/US2004/028766 WO2005026687A2 (en) 2003-09-05 2004-09-03 Diagnosis and monitoring of hepatocellular carcinoma

Publications (3)

Publication Number Publication Date
JP2007506945A JP2007506945A (ja) 2007-03-22
JP2007506945A5 JP2007506945A5 (enExample) 2007-10-18
JP4574619B2 true JP4574619B2 (ja) 2010-11-04

Family

ID=34312211

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006525478A Expired - Fee Related JP4574619B2 (ja) 2003-09-05 2004-09-03 肝細胞癌の検査及び監視

Country Status (7)

Country Link
US (1) US20050112711A1 (enExample)
EP (1) EP1664718B1 (enExample)
JP (1) JP4574619B2 (enExample)
AT (1) ATE451477T1 (enExample)
DE (1) DE602004024549D1 (enExample)
ES (1) ES2337791T3 (enExample)
WO (1) WO2005026687A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718369B2 (en) 2005-09-12 2010-05-18 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2008021163A2 (en) * 2006-08-09 2008-02-21 Saint Louis University Kits and methods for determining risk for primary liver cancer
AU2007320051B2 (en) * 2006-10-27 2012-11-08 Inova Diagnostics, Inc. Methods and assays for detecting GP73-specific autoantibodies
AU2007317306B2 (en) * 2006-11-08 2012-06-14 The Regents Of The University Of Michigan SPINK1 as a prostate cancer marker and uses thereof
JP5433572B2 (ja) 2007-07-06 2014-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Ｍｉｐｏｌ１−ｅｔｖ１遺伝子再編成
CN101988926A (zh) * 2009-08-03 2011-03-23 中国科学院广州生物医药与健康研究院 一种高尔基蛋白gp73的夹心elisa定量检测方法及其检测试剂盒
JP5800817B2 (ja) 2009-09-17 2015-10-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
CN102854324B (zh) * 2012-08-17 2014-10-22 西北大学 快速无损伤性检测肝肿瘤标志物的方法以及采用的试纸条
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
CN104215761B (zh) * 2014-08-27 2016-04-20 广西医科大学 检测血清中抗gp73抗体的试剂盒
CN105699653B (zh) * 2014-11-25 2017-08-25 北京市肝病研究所 一种超敏感超顺磁性纳米免疫微球及其检测gp73抗原的方法
CN104360080B (zh) * 2014-12-05 2016-03-02 重庆乾德生物技术有限公司 一种高尔基体糖蛋白-73检测试剂盒
CN107345967A (zh) * 2016-05-05 2017-11-14 中国医学科学院基础医学研究所 Gp73蛋白作为血清标记物在诊断癌症中的用途
CN106405104B (zh) * 2016-08-31 2019-01-08 鲁凤民 一种新的肝硬化或肝纤维化标志物
CN111413502B (zh) * 2017-04-27 2022-10-14 北京大学 Gp73的新用途及一种基于其的肝组织炎症活动度检测试剂盒
US20200232044A1 (en) * 2017-10-02 2020-07-23 Universität Zu Köln Tumor and metastasizing marker
CN107746430B (zh) * 2017-10-19 2021-03-23 天津金虹生物科技开发有限公司 一种gp73 c端抗原的制备及其应用
CN115754290A (zh) * 2022-09-26 2023-03-07 浙江大学 一种用于检测早期肝癌的试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733738A (en) * 1983-08-17 1998-03-31 Ligand Pharmaceuticals Polypeptide-induced monoclonal receptors to protein ligands
DE10136273A1 (de) * 2001-07-25 2003-02-13 Sabine Debuschewitz Molekulare Marker beim hepatozellulären Karzinom
US7229774B2 (en) * 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
AU2007320051B2 (en) * 2006-10-27 2012-11-08 Inova Diagnostics, Inc. Methods and assays for detecting GP73-specific autoantibodies

Also Published As

Publication number Publication date
ES2337791T3 (es) 2010-04-29
WO2005026687A3 (en) 2006-06-22
US20050112711A1 (en) 2005-05-26
WO2005026687A2 (en) 2005-03-24
DE602004024549D1 (de) 2010-01-21
ATE451477T1 (de) 2009-12-15
JP2007506945A (ja) 2007-03-22
EP1664718A2 (en) 2006-06-07
EP1664718A4 (en) 2007-09-19
EP1664718B1 (en) 2009-12-09

Similar Documents

Publication Publication Date Title
JP4574619B2 (ja) 肝細胞癌の検査及び監視
Marrero et al. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma
JP6941324B2 (ja) 新規な肝硬変または肝線維症のマーカー
Seow et al. Hepatocellular carcinoma: from bedside to proteomics
Huang et al. CHI3L1 is a liver-enriched, noninvasive biomarker that can be used to stage and diagnose substantial hepatic fibrosis
Qiao et al. Serum gp73 is also a biomarker for diagnosing cirrhosis in population with chronic HBV infection
Brisuda et al. Urinary cell-free DNA quantification as non-invasive biomarker in patients with bladder cancer
KR20090098490A (ko) 간암 진단용 단백질성 마커
CN103698511B (zh) 结核分支杆菌蛋白在制备诊断潜伏性肺结核感染的产品中的用途
JP5704684B2 (ja) ＩｇＧ４関連疾患診断用マーカー及びその利用
KR20150058465A (ko) 피험체에서 간암을 진단하는 방법 및 간암을 진단하기 위한 키트
Hanash et al. PREVALENCE AND GENOTYPING OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS AND EVALUATION OF HCV-CORE ANTIGEN TEST IN SCREENING PATIENTS FOR DIALYSIS IN SANA'A CITY, YEMEN
US20130316332A1 (en) Combination of biomarkers for the prognosis of response or non-response to an anti-hcv treatment
CN108738347A (zh) 辅助肝细胞癌患者的再发风险预测的方法、装置、计算机程序制品及试剂盒
Liu et al. HBcrAg is associated with prognosis of hepatitis B virus‐related hepatocellular carcinoma in patients after hepatectomy undergoing antiviral therapy
WO2022053944A1 (en) Immunoassay for the detection of antibodies against merkel cell polyomavirus (mcpyv) using synthetic peptides
TWI816286B (zh) 偵測肝細胞癌的方法
Rahman et al. Trends of Hepatorenal Variations in Hepatitis-C Patients Visiting THQ Level Hospital in Arifwala Punjab: Hepatorenal Variations in Hepatitis-C Patients
WO2024004675A1 (ja) 肝臓癌の発症可能性を検査する方法
AbdelAziz et al. Molecular Evaluation of Midikine (Mdk) As A Potential Biomarker Todetect Hepatocellular Carcinoma
Attallah et al. Non‐invasive predictive score of fibrosis stages in chronic hepatitis C patients based on epithelial membrane antigen in the blood in combination with routine laboratory markers
US20140051079A1 (en) Method for predicting the response to a treatment against hepatitis c
CN115786491A (zh) Lcn2、fcn1作为标志物在糖尿病合并结核病诊断、预后及疗效评估中的应用
Paranagua-Vezozzo et al. High values of liver stiffness play an important role in stratifying the risk of hepatocellular carcinoma in cirrhotic hepatitis C patients.
Nguyen et al. Unexpectedly Low Prevalence of Hepatitis Delta Virus Infection in Southern Viet Nam

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070831

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070831

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091117

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100217

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100514

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100803

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100818

R150 Certificate of patent or registration of utility model

Ref document number: 4574619

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130827

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees