JP4557971B2 - 血液試料からの神経損傷の評価 - Google Patents

血液試料からの神経損傷の評価 Download PDF

Info

Publication number
JP4557971B2
JP4557971B2 JP2006509274A JP2006509274A JP4557971B2 JP 4557971 B2 JP4557971 B2 JP 4557971B2 JP 2006509274 A JP2006509274 A JP 2006509274A JP 2006509274 A JP2006509274 A JP 2006509274A JP 4557971 B2 JP4557971 B2 JP 4557971B2
Authority
JP
Japan
Prior art keywords
antibody
blood
detecting
injury
nerve damage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006509274A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006522336A (ja
JP2006522336A5 (enExample
Inventor
ショー、ゲリー
アール． パイク、ブライアン
エス． テュリ、ソナル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of JP2006522336A publication Critical patent/JP2006522336A/ja
Publication of JP2006522336A5 publication Critical patent/JP2006522336A5/ja
Application granted granted Critical
Publication of JP4557971B2 publication Critical patent/JP4557971B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2006509274A 2003-03-31 2004-03-26 血液試料からの神経損傷の評価 Expired - Fee Related JP4557971B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45928603P 2003-03-31 2003-03-31
PCT/US2004/009114 WO2004091379A2 (en) 2003-03-31 2004-03-26 Assessing neuronal damage from blood samples

Publications (3)

Publication Number Publication Date
JP2006522336A JP2006522336A (ja) 2006-09-28
JP2006522336A5 JP2006522336A5 (enExample) 2007-04-19
JP4557971B2 true JP4557971B2 (ja) 2010-10-06

Family

ID=33299668

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006509274A Expired - Fee Related JP4557971B2 (ja) 2003-03-31 2004-03-26 血液試料からの神経損傷の評価

Country Status (10)

Country Link
US (3) US20040241762A1 (enExample)
EP (1) EP1613204B1 (enExample)
JP (1) JP4557971B2 (enExample)
AT (1) ATE440286T1 (enExample)
AU (1) AU2004229317B2 (enExample)
CA (1) CA2520945C (enExample)
DE (1) DE602004022645D1 (enExample)
DK (1) DK1613204T3 (enExample)
ES (1) ES2332136T3 (enExample)
WO (1) WO2004091379A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113798A2 (en) * 2004-04-15 2005-12-01 University Of Florida Research Foundation, Inc. Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
US20070276275A1 (en) * 2006-05-24 2007-11-29 University Of Miami Screening method and system to estimate the severity of injury in critically ill patients
JPWO2008078809A1 (ja) * 2006-12-27 2010-04-30 独立行政法人科学技術振興機構 鳥類抗体を使用する免疫学的検出方法
US20140038834A1 (en) * 2010-07-07 2014-02-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Novel biomarkers for detecting neuronal loss
EP3129780A4 (en) * 2014-04-07 2017-12-13 Iron Horse Diagnostics Inc. Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
CN112823048A (zh) * 2018-07-27 2021-05-18 维拉维斯公司 消除和富集的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU86652A1 (de) * 1986-11-10 1988-06-13 Progen Biotechnik Gmbh Verfahren zum auffinden von gewebslaesionen
DE68927459T2 (de) * 1988-12-21 1997-04-24 Gen Hospital Corp Nachweis einer neurologischen Krankheit oder einer Funktionsstörung
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
GB9719879D0 (en) * 1997-09-19 1997-11-19 Neuropa Ltd Protein
US6589746B1 (en) * 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury

Also Published As

Publication number Publication date
EP1613204A2 (en) 2006-01-11
EP1613204B1 (en) 2009-08-19
WO2004091379A2 (en) 2004-10-28
AU2004229317B2 (en) 2012-01-12
US20160349272A1 (en) 2016-12-01
ATE440286T1 (de) 2009-09-15
DE602004022645D1 (de) 2009-10-01
WO2004091379A3 (en) 2005-12-22
DK1613204T3 (da) 2009-12-07
HK1085538A1 (en) 2006-08-25
CA2520945C (en) 2014-03-25
JP2006522336A (ja) 2006-09-28
US20040241762A1 (en) 2004-12-02
AU2004229317A1 (en) 2004-10-28
EP1613204A4 (en) 2007-04-04
US20100184105A1 (en) 2010-07-22
CA2520945A1 (en) 2004-10-28
ES2332136T3 (es) 2010-01-27

Similar Documents

Publication Publication Date Title
JP5307543B2 (ja) 天然形態ヒトオートタキシン特異的抗体、そのスクリーニング方法、及びオートタキシン測定による悪性リンパ腫の検査方法および検査薬
US20160349272A1 (en) Assessing neuronal damage from blood samples
JP7449530B2 (ja) 腎癌の検出方法及び検査薬
CN114573692A (zh) 用于检测嗜铬粒蛋白a的免疫测定与抗体
WO2009014342A2 (en) Markers and kit for diagnosis of alzheimer's disease
JP2009500597A (ja) 線維症のマーカー
US11242408B2 (en) Monoclonal antibody specific for gamma-glutamyl-l-epsilon-lysine for the monitoring of apoptosis
JP7307479B2 (ja) ＩｇＡ腎症診断用キット
HK1085538B (en) Assessing neuronal damage from blood samples
KR102145438B1 (ko) 퇴행성 뇌질환 발병 위험성 예측용 조성물 및 이를 이용한 퇴행성 뇌질환의 발병 위험성 예측 방법
AU625894B2 (en) Method of primary diagnosis for sick animals, diagnostic reagent for such method and manufacturing method of the reagent
AU2012202051A1 (en) Assessing neuronal damage from blood samples
WO2025182761A1 (ja) Ｇｆａｐの検出方法、アルツハイマー病の診断を補助する方法、及びそれらに用いるキット
KR20200099119A (ko) 퇴행성 뇌질환 발병 위험성 예측용 조성물 및 이를 이용한 퇴행성 뇌질환의 발병 위험성 예측 방법
CN114527275A (zh) 肝纤维化的诊断试剂盒
JP2025501182A (ja) Ｔｂｉ（外傷性脳損傷）に対して陰性である、頭部コンピュータ断層撮影（ｃｔ）スキャンを受けたことがある又は頭部ｃｔスキャンを受けたことがない対象において亜急性外傷性脳損傷（ｔｂｉ）を決定するためのバイオマーカーの使用
JP4505800B2 (ja) 抗腎タイプｉｖモノクロ−ナル抗体
CN117751288A (zh) 评价儿科受试者的脑损伤的方法
JP2023552755A (ja) 頭部コンピュータ断層撮影スキャンの結果が外傷性脳損傷（ｔｂｉ）に関して陰性の対象においてｔｂｉを判定するための１種以上のバイオマーカーの使用
HK40012576A (en) Improved methods of assessing gfap status in patient samples
HK40012577A (en) Improved methods of assessing uch-l1 status in patient samples
HK40012576B (zh) 评估患者样品中gfap状态的改进方法
JPH06317588A (ja) 腎疾患の検査方法，検査試薬およびキット
JP2001289859A (ja) 多発性硬化症の診断方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070305

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070305

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20091015

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091027

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100127

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100629

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100720

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130730

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees