JP4542262B2 - アロエからの免疫修飾性多糖類の製法 - Google Patents

アロエからの免疫修飾性多糖類の製法 Download PDF

Info

Publication number
JP4542262B2
JP4542262B2 JP2000516056A JP2000516056A JP4542262B2 JP 4542262 B2 JP4542262 B2 JP 4542262B2 JP 2000516056 A JP2000516056 A JP 2000516056A JP 2000516056 A JP2000516056 A JP 2000516056A JP 4542262 B2 JP4542262 B2 JP 4542262B2
Authority
JP
Japan
Prior art keywords
immuno
polysaccharide
aloe
composition
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000516056A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001520019A5 (enExample
JP2001520019A (ja
Inventor
キウ、ズヒハウ
マヒオウ、ベライド
Original Assignee
ユニゲン・ファーマシューティカルス・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニゲン・ファーマシューティカルス・インコーポレーテッド filed Critical ユニゲン・ファーマシューティカルス・インコーポレーテッド
Publication of JP2001520019A publication Critical patent/JP2001520019A/ja
Publication of JP2001520019A5 publication Critical patent/JP2001520019A5/ja
Application granted granted Critical
Publication of JP4542262B2 publication Critical patent/JP4542262B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2000516056A 1997-10-10 1998-10-09 アロエからの免疫修飾性多糖類の製法 Expired - Fee Related JP4542262B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6168197P 1997-10-10 1997-10-10
US60/061,681 1997-10-10
US9827198P 1998-08-28 1998-08-28
US60/098,271 1998-08-28
PCT/US1998/021361 WO1999019505A1 (en) 1997-10-10 1998-10-09 Process for the preparation of immunomodulatory polysaccharides from aloe

Publications (3)

Publication Number Publication Date
JP2001520019A JP2001520019A (ja) 2001-10-30
JP2001520019A5 JP2001520019A5 (enExample) 2006-01-05
JP4542262B2 true JP4542262B2 (ja) 2010-09-08

Family

ID=26741367

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000516056A Expired - Fee Related JP4542262B2 (ja) 1997-10-10 1998-10-09 アロエからの免疫修飾性多糖類の製法

Country Status (5)

Country Link
US (3) US6133440A (enExample)
EP (1) EP1036187A4 (enExample)
JP (1) JP4542262B2 (enExample)
KR (2) KR100729887B1 (enExample)
WO (1) WO1999019505A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096378A1 (en) * 1997-10-10 2003-05-22 Univera Pharmaceuticals, Inc. Process for the preparation of immunomodulatory polysaccharides from aloe
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US7196072B2 (en) * 2000-07-10 2007-03-27 University Of Mississippi High molecular weight polysaccharide fraction from Aloe vera with immunostimulatory activity
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
EP1323738A1 (en) * 2001-12-27 2003-07-02 2QR Research BV Negatively charged polysaccharide derivable form Aloe Vera
US20050004211A1 (en) * 2003-06-30 2005-01-06 Kaohsiung Medical University Pharmaceutical compositions comprising aryl-substituted acyclic enediyne compounds
US7754704B2 (en) 2004-03-31 2010-07-13 Morinaga Milk Industry Co., Ltd. Method for treating hyperglycemia
KR100743852B1 (ko) 2004-03-31 2007-08-02 모리나가 뉴교 가부시키가이샤 4-메틸에르고스트-7-엔-3-올 골격을 갖는 글리코사이드 및고혈당 개선제
US7507424B2 (en) * 2004-04-26 2009-03-24 Mmi Corporation Natural immunostimulant compositions, methods for obtaining the same and pharmaceutical formulations thereof
US7175860B2 (en) * 2004-08-02 2007-02-13 Haskell Pharmaceuticals, Inc. Enhanced wound healing method and composition
US7410661B2 (en) * 2004-08-02 2008-08-12 Weston Haskell Enhanced wound healing method, product and composition
JP3924310B2 (ja) 2004-09-29 2007-06-06 森永乳業株式会社 高血糖改善のための医薬及び飲食品
US20060084629A1 (en) * 2004-10-15 2006-04-20 Alvin Needleman Immune system activating formula composed of selected long chain polysaccharides from natural sources
RU2353368C1 (ru) 2005-05-17 2009-04-27 Моринага Милк Индастри Ко., Лтд. Лекарственное средство и пищевой продукт или напиток для улучшения функций поджелудочной железы
CA2584974C (en) 2005-05-17 2010-04-20 Morinaga Milk Industry Co., Ltd. Drug and food or drink for improving pancreatic functions
US7531520B2 (en) 2005-05-17 2009-05-12 Morinaga Milk Industry Co., Ltd. Drug and food or drink for improving pancreatic functions
US20070036840A1 (en) * 2005-07-27 2007-02-15 Jose Antonio Matji Tuduri Phosphorylated glucomannan polysaccharides containing 1-6 and 1-2 linkages increase weight gain in swine
JP4954523B2 (ja) * 2005-09-26 2012-06-20 長谷川香料株式会社 高濃度のｓ−アルケニル（またはアルキル）システインスルフォキサイド類を含有する抽出物の製造方法
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
CN103083642B (zh) * 2007-05-11 2015-11-18 芦荟研究实验室公司 用于皮肤增强的芦荟制剂
CN101980695B (zh) * 2008-05-16 2013-05-22 株式会社日冷生物科学 由兰科植物得到的提取物、生产所述提取物的方法和包含所述提取物的皮肤外用剂
MX374804B (es) * 2008-10-14 2025-03-06 Nerium Biotechnology Inc Proceso para extraer glucósidos cardíacos y composiciones.
US7833829B2 (en) * 2008-10-28 2010-11-16 Honeywell International Inc. MEMS devices and methods of assembling micro electromechanical systems (MEMS)
JP4761584B2 (ja) * 2008-11-07 2011-08-31 長谷川香料株式会社 粘性物質の除去されたアロエ葉肉加工品の製造方法
US8604187B2 (en) 2010-01-14 2013-12-10 North Texas Medical Associates Compositions and methods of aloe polysaccharides
AU2011353765B2 (en) * 2011-01-06 2017-04-06 Bespoke Bioscience, Llc Compositions and methods of aloe polysaccharides
KR101502219B1 (ko) * 2013-07-03 2015-03-13 제주알로에영농조합법인 알로에 효소 추출물 또는 이의 분획물을 함유하는 항산화 조성물
MX2016011427A (es) * 2014-03-20 2016-12-02 Morinaga Milk Industry Co Ltd Metodo para fabricar extracto de aloe, y extracto de aloe.
MX372720B (es) 2014-04-17 2020-05-27 Unilever Ip Holdings B V Extracto de aloe vera para composiciones para el cuidado personal.
CN106456524B (zh) * 2014-04-17 2019-12-10 荷兰联合利华有限公司 个人护理组合物
KR101772894B1 (ko) * 2015-07-14 2017-08-31 코스맥스 주식회사 스팀 처리를 이용한 알로에 다당체의 제조방법
JP6129947B2 (ja) * 2015-12-28 2017-05-17 ビスポーク バイオサイエンス，エルエルシー アロエ多糖体の組成物及び方法
US10076552B2 (en) 2016-08-09 2018-09-18 DATT MEDIPRODUCTS LIMITED and DATT LIFE SCIENCE PVT. LTD. Multifunctional formulation comprised of natural ingredients and method of preparation/manufacturing thereof
CN112533614A (zh) 2018-03-28 2021-03-19 美国康宝莱国际公司 多糖的乙酰化
JP2023533971A (ja) * 2020-07-09 2023-08-07 ユニゲン・インコーポレーテッド 多糖類とポリフェノールを含有する免疫恒常性の調節用アロエベース組成物
WO2022250313A1 (ko) * 2021-05-27 2022-12-01 주식회사 유니베라 알로에 베라 꽃 추출물, 또는 알로에 베라 꽃 추출물 및 알로에 베라 다당체를 유효성분으로 함유하는 피부 보습, 재생 촉진 및 상처 치료용 조성물
KR102790858B1 (ko) * 2021-08-25 2025-04-07 주식회사 엘지생활건강 고분자 다당체를 포함하는 알로에 즙
KR102517668B1 (ko) * 2022-10-25 2023-04-05 (주)바이텍 효소처리 알로에 베라를 포함하는 유산균 동결건조 보호용 조성물

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892853A (en) * 1967-05-22 1975-07-01 Aloe 99 & 0 Inc Stabilized aloe vera gel and preparation of same
US3470109A (en) * 1968-01-31 1969-09-30 Aloe Creme Lab Inc Method of making reconstitutable aloe gel in crystalline form
US4178372A (en) * 1978-03-06 1979-12-11 Coats Billy C Hypoallergenic stabilized aloe vera gel
US4966892A (en) * 1982-05-07 1990-10-30 Carrington Laboratories, Inc. Processes for preparation of aloe products products produced thereby and compositions thereof
US5106616A (en) * 1988-01-14 1992-04-21 Carrington Laboratories, Inc. Administration of acemannan
US4735935A (en) * 1985-12-17 1988-04-05 Carrington Laboratories, Inc. Process for preparation of aloe products products, produced thereby and compositions thereof
US4917890A (en) * 1985-06-28 1990-04-17 Carrington Laboratories, Inc. Processes for preparation of aloe products, products produced thereby and compositions thereof
US5118673A (en) * 1982-05-07 1992-06-02 Carrington Laboratories, Inc. Uses of aloe products
US4851224A (en) * 1986-06-05 1989-07-25 Carrington Laboratories, Inc. Process for preparation of aloe products
US5468737A (en) * 1982-05-07 1995-11-21 Carrington Laboratories, Inc. Wound healing accelerated by systemic administration of polysaccharide from aloe
US5308838A (en) * 1982-05-07 1994-05-03 Carrington Laboratories, Inc. Uses of aloe products
US5443830A (en) * 1982-05-07 1995-08-22 Carrington Laboratories, Inc. Drink containing mucilaginous polysaccharides and its preparation
US4555987A (en) * 1983-07-22 1985-12-03 Tumlinson Larry N Method and apparatus for extraction of aloe vera gel
US4959214A (en) * 1985-06-28 1990-09-25 Carrington Laboratories Inc. Processes for preparation of aloe products products produced thereby and compositions thereof
US4957907A (en) * 1985-06-28 1990-09-18 Carrington Laboratories Inc. Process for preparation of aloe products
JPS62263193A (ja) * 1986-05-09 1987-11-16 Ichimaru Pharcos Co Ltd アロエ由来水溶性抽出物
US5562906A (en) * 1989-09-12 1996-10-08 Terry; James M. Method for the treatment of vascular disorders
AU2254192A (en) * 1991-06-24 1993-01-25 Carrington Laboratories, Inc. Wound cleanser
US5356811A (en) * 1992-04-21 1994-10-18 Coats Billy C Method of processing stabilized aloe vera gel obtained from the whole aloe vera leaf
US5512488A (en) * 1994-05-05 1996-04-30 Carrington Laboratories, Inc. Colorimetric assay for bioactive polysaccharide
US5824659A (en) * 1996-09-04 1998-10-20 Board Of Regents, The University Of Texas System Cytoprotective oligosaccharide from Aloe preventing damage to the skin immune system by UV radiation

Also Published As

Publication number Publication date
US6436679B1 (en) 2002-08-20
JP2001520019A (ja) 2001-10-30
KR100729887B1 (ko) 2007-06-18
KR20060103285A (ko) 2006-09-28
KR20010015736A (ko) 2001-02-26
EP1036187A4 (en) 2002-03-27
WO1999019505A1 (en) 1999-04-22
EP1036187A1 (en) 2000-09-20
US6271214B1 (en) 2001-08-07
KR100678238B1 (ko) 2007-02-01
US6133440A (en) 2000-10-17

Similar Documents

Publication Publication Date Title
JP4542262B2 (ja) アロエからの免疫修飾性多糖類の製法
DE60103066T2 (de) Chlorella zubereitungen mit immunmodulatorischen eigenschaften
CN1968708B (zh) 用于治疗和预防与免疫系统缺陷有关的疾病的含鳄梨肽提取物的药物
JP2006515290A (ja) ウィタニアソムニフェラ組成物、それを得るための方法、並びにその医薬製剤、栄養剤およびパーソナルケア製剤
WO1998009635A9 (en) Cytoprotective oligosaccharide from aloe preventing damage to the skin immune system by uv radiation
WO1998009635A1 (en) Cytoprotective oligosaccharide from aloe preventing damage to the skin immune system by uv radiation
US20030096378A1 (en) Process for the preparation of immunomodulatory polysaccharides from aloe
JPH0539305A (ja) アストラガルス・メンブラナセウスから抽出した免疫 変調性多糖類及びこれらを含有する薬剤組成物
US4762825A (en) Polysaccharide RON substance
EP1789439B1 (en) A purified arabinogalactan-protein (agp) composition
JPS6219525A (ja) 植物起源の生物活性物質の製造法および同物質含有組成物
KR20140114921A (ko) 피부 보습용 알로에 조성물
KR100549662B1 (ko) 러시아산 무미 추출물 또는 분획물을 함유하는면역활성증강용 조성물
KR102477052B1 (ko) 선복화 단백다당체 또는 선복화 올리고당/펩타이드 복합체를 유효성분으로 함유하는 피부 외용제 조성물 및 이의 제조방법
US4442087A (en) Interferon inducer, a process for producing the same and pharmaceutical composition containing the same
KR20180124443A (ko) 흰목이버섯 자실체 추출물을 포함하는 피부장벽강화용 화장료 조성물
EP0173228A2 (en) Polysaccharide rin substance, production of the same and use of the same
AU2001218789B2 (en) Polysaccharide compound having immune stimulating activity
JP3254567B2 (ja) 植物組織からの生理活性物質の製造方法及びこの物質を含有する組成物
CN120025466A (zh) 一种莲花酸性多糖、其制备工艺和新用途
TWI296526B (en) Polysaccharide compound having immune stimulating activity
GB2042558A (en) Interferon inducers, methods for their preparation, pharmaceutical compositions containing them and their use as medicaments
EP2305280A1 (en) Bcl-2 protein expressor, apoptosis inhibitor and preventive for uv-dna damage in epidermal cells
HK1062178B (en) Polysaccharide compound having immune stimulating activity
ZA200304444B (en) Polysaccharide compound having immune stimulating activity.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051006

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051006

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081014

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20090109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090113

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090123

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20090312

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090408

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100115

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100510

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20100524

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100604

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100625

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130702

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130702

Year of fee payment: 3

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130702

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees