JP4540986B2 - ワートマニン類似体およびそれらを用いる方法 - Google Patents

ワートマニン類似体およびそれらを用いる方法 Download PDF

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Publication number
JP4540986B2
JP4540986B2 JP2003528088A JP2003528088A JP4540986B2 JP 4540986 B2 JP4540986 B2 JP 4540986B2 JP 2003528088 A JP2003528088 A JP 2003528088A JP 2003528088 A JP2003528088 A JP 2003528088A JP 4540986 B2 JP4540986 B2 JP 4540986B2
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Japan
Prior art keywords
wortmannin
compound
analogs
present
drug
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Expired - Fee Related
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JP2003528088A
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English (en)
Japanese (ja)
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JP2005507880A5 (enExample
JP2005507880A (ja
Inventor
パウウィス、ガース
ウィプフ、ピーター
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University of Arizona
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University of Arizona
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
JP2003528088A 2001-09-14 2002-09-16 ワートマニン類似体およびそれらを用いる方法 Expired - Fee Related JP4540986B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32214301P 2001-09-14 2001-09-14
US32213901P 2001-09-14 2001-09-14
PCT/US2002/029365 WO2003024183A2 (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Publications (3)

Publication Number Publication Date
JP2005507880A JP2005507880A (ja) 2005-03-24
JP2005507880A5 JP2005507880A5 (enExample) 2006-01-05
JP4540986B2 true JP4540986B2 (ja) 2010-09-08

Family

ID=26983283

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003528088A Expired - Fee Related JP4540986B2 (ja) 2001-09-14 2002-09-16 ワートマニン類似体およびそれらを用いる方法

Country Status (8)

Country Link
EP (1) EP1435941B8 (enExample)
JP (1) JP4540986B2 (enExample)
AT (1) ATE334671T1 (enExample)
AU (1) AU2002330029B2 (enExample)
CA (1) CA2458318C (enExample)
DE (1) DE60213633T2 (enExample)
MX (1) MXPA04002445A (enExample)
WO (1) WO2003024183A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
US7230139B2 (en) 2002-12-05 2007-06-12 Gemin X Biotechnologies Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
CA2522980A1 (en) * 2003-04-23 2004-11-04 Wyeth Holdings Corporation Water soluble wortmannin derivatives
DE102004043463A1 (de) * 2004-06-09 2006-02-09 Heinz Voigt Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten
AU2005333515B2 (en) * 2004-07-09 2012-05-10 Arizona Board Of Regents, Acting On Behalf Of The University Of Arizona Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
TW200626610A (en) * 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
WO2006132675A2 (en) * 2004-12-20 2006-12-14 University Of South Florida Xiap-targeted prostate cancer therapy
EP1940386A4 (en) * 2005-09-01 2010-06-23 Beth Israel Hospital WORDMAN'S CONJUGATES AND USES THEREOF
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
EP1965790B1 (en) * 2005-12-30 2011-12-07 Arizona Board of Regents, Acting on Behalf of The University of Arizona Metabolites of wortmannin analogs and methods of using the same
EP2012794B1 (en) * 2006-04-13 2014-09-17 The Trustees of Columbia University in the City of New York Compositions and intraluminal devices for inhibiting vascular stenosis
AU2011261243A1 (en) * 2010-06-04 2012-12-20 Oncothyreon Inc. Combination cancer therapies with wortmannin analogs
WO2011153495A1 (en) * 2010-06-04 2011-12-08 Oncothyreon,Inc. Cancer treatment with wortmannin analogs
US11197854B1 (en) 2018-11-14 2021-12-14 National Technology & Engineering Solutions Of Sandia, Llc Inhibitors for targeting flaviviruses
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited ANTIBODY-DRUG CONJUGATE AND KINAS INHIBITOR COMBINATION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Also Published As

Publication number Publication date
EP1435941A2 (en) 2004-07-14
DE60213633T2 (de) 2007-11-08
AU2002330029B2 (en) 2006-07-06
CA2458318C (en) 2011-03-15
MXPA04002445A (es) 2005-07-25
ATE334671T1 (de) 2006-08-15
WO2003024183A2 (en) 2003-03-27
EP1435941B8 (en) 2006-10-25
EP1435941B1 (en) 2006-08-02
EP1435941A4 (en) 2004-12-08
JP2005507880A (ja) 2005-03-24
CA2458318A1 (en) 2003-03-27
DE60213633D1 (de) 2006-09-14
WO2003024183A3 (en) 2003-06-12

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