AU2002330029B2 - Wortmannin analogs and methods of using same - Google Patents

Wortmannin analogs and methods of using same Download PDF

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Publication number
AU2002330029B2
AU2002330029B2 AU2002330029A AU2002330029A AU2002330029B2 AU 2002330029 B2 AU2002330029 B2 AU 2002330029B2 AU 2002330029 A AU2002330029 A AU 2002330029A AU 2002330029 A AU2002330029 A AU 2002330029A AU 2002330029 B2 AU2002330029 B2 AU 2002330029B2
Authority
AU
Australia
Prior art keywords
wortmannin
compound
analogs
kinase
djm2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002330029A
Other languages
English (en)
Other versions
AU2002330029A1 (en
Inventor
Garth Powis
Peter Wipf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
University of Arizona
Original Assignee
University of Pittsburgh
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh, University of Arizona filed Critical University of Pittsburgh
Publication of AU2002330029A1 publication Critical patent/AU2002330029A1/en
Priority to AU2006202635A priority Critical patent/AU2006202635B2/en
Application granted granted Critical
Publication of AU2002330029B2 publication Critical patent/AU2002330029B2/en
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, UNIVERSITY OF PITTSBURGH reassignment ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA Amend patent request/document other than specification (104) Assignors: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
AU2002330029A 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same Ceased AU2002330029B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006202635A AU2006202635B2 (en) 2001-09-14 2006-06-21 Wortmannin analogs and methods of using same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32214301P 2001-09-14 2001-09-14
US32213901P 2001-09-14 2001-09-14
US60/322,143 2001-09-14
US60/322,139 2001-09-14
PCT/US2002/029365 WO2003024183A2 (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2006202635A Division AU2006202635B2 (en) 2001-09-14 2006-06-21 Wortmannin analogs and methods of using same

Publications (2)

Publication Number Publication Date
AU2002330029A1 AU2002330029A1 (en) 2003-06-05
AU2002330029B2 true AU2002330029B2 (en) 2006-07-06

Family

ID=26983283

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002330029A Ceased AU2002330029B2 (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Country Status (8)

Country Link
EP (1) EP1435941B8 (enExample)
JP (1) JP4540986B2 (enExample)
AT (1) ATE334671T1 (enExample)
AU (1) AU2002330029B2 (enExample)
CA (1) CA2458318C (enExample)
DE (1) DE60213633T2 (enExample)
MX (1) MXPA04002445A (enExample)
WO (1) WO2003024183A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
US7230139B2 (en) 2002-12-05 2007-06-12 Gemin X Biotechnologies Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
CA2522980A1 (en) * 2003-04-23 2004-11-04 Wyeth Holdings Corporation Water soluble wortmannin derivatives
DE102004043463A1 (de) * 2004-06-09 2006-02-09 Heinz Voigt Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten
AU2005333515B2 (en) * 2004-07-09 2012-05-10 Arizona Board Of Regents, Acting On Behalf Of The University Of Arizona Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
TW200626610A (en) * 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
WO2006132675A2 (en) * 2004-12-20 2006-12-14 University Of South Florida Xiap-targeted prostate cancer therapy
EP1940386A4 (en) * 2005-09-01 2010-06-23 Beth Israel Hospital WORDMAN'S CONJUGATES AND USES THEREOF
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
EP1965790B1 (en) * 2005-12-30 2011-12-07 Arizona Board of Regents, Acting on Behalf of The University of Arizona Metabolites of wortmannin analogs and methods of using the same
EP2012794B1 (en) * 2006-04-13 2014-09-17 The Trustees of Columbia University in the City of New York Compositions and intraluminal devices for inhibiting vascular stenosis
AU2011261243A1 (en) * 2010-06-04 2012-12-20 Oncothyreon Inc. Combination cancer therapies with wortmannin analogs
WO2011153495A1 (en) * 2010-06-04 2011-12-08 Oncothyreon,Inc. Cancer treatment with wortmannin analogs
US11197854B1 (en) 2018-11-14 2021-12-14 National Technology & Engineering Solutions Of Sandia, Llc Inhibitors for targeting flaviviruses
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited ANTIBODY-DRUG CONJUGATE AND KINAS INHIBITOR COMBINATION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Helvetica Chimica Acta (1975), 58, 1620-1628 *
Journal of Medicinal Chemistry (1996), 39, 1106-1111 *

Also Published As

Publication number Publication date
EP1435941A2 (en) 2004-07-14
DE60213633T2 (de) 2007-11-08
CA2458318C (en) 2011-03-15
MXPA04002445A (es) 2005-07-25
JP4540986B2 (ja) 2010-09-08
ATE334671T1 (de) 2006-08-15
WO2003024183A2 (en) 2003-03-27
EP1435941B8 (en) 2006-10-25
EP1435941B1 (en) 2006-08-02
EP1435941A4 (en) 2004-12-08
JP2005507880A (ja) 2005-03-24
CA2458318A1 (en) 2003-03-27
DE60213633D1 (de) 2006-09-14
WO2003024183A3 (en) 2003-06-12

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Legal Events

Date Code Title Description
NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO ENTER THE NATIONAL PHASE HAS BEEN EXTENDED TO 28 APR 2004.

TC Change of applicant's name (sec. 104)

Owner name: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSI

Free format text: FORMER NAME: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired