CA2458318C - Wortmannin analogs and methods of using same - Google Patents

Wortmannin analogs and methods of using same Download PDF

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Publication number
CA2458318C
CA2458318C CA2458318A CA2458318A CA2458318C CA 2458318 C CA2458318 C CA 2458318C CA 2458318 A CA2458318 A CA 2458318A CA 2458318 A CA2458318 A CA 2458318A CA 2458318 C CA2458318 C CA 2458318C
Authority
CA
Canada
Prior art keywords
wortmannin
compound
cancer
analogs
djm2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2458318A
Other languages
English (en)
French (fr)
Other versions
CA2458318A1 (en
Inventor
Garth Powis
Peter Wipf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
University of Arizona
Original Assignee
University of Pittsburgh
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh, University of Arizona filed Critical University of Pittsburgh
Publication of CA2458318A1 publication Critical patent/CA2458318A1/en
Application granted granted Critical
Publication of CA2458318C publication Critical patent/CA2458318C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2458318A 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same Expired - Fee Related CA2458318C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32214301P 2001-09-14 2001-09-14
US32213901P 2001-09-14 2001-09-14
US60/322,143 2001-09-14
US60/322,139 2001-09-14
PCT/US2002/029365 WO2003024183A2 (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Publications (2)

Publication Number Publication Date
CA2458318A1 CA2458318A1 (en) 2003-03-27
CA2458318C true CA2458318C (en) 2011-03-15

Family

ID=26983283

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2458318A Expired - Fee Related CA2458318C (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Country Status (8)

Country Link
EP (1) EP1435941B8 (enExample)
JP (1) JP4540986B2 (enExample)
AT (1) ATE334671T1 (enExample)
AU (1) AU2002330029B2 (enExample)
CA (1) CA2458318C (enExample)
DE (1) DE60213633T2 (enExample)
MX (1) MXPA04002445A (enExample)
WO (1) WO2003024183A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
US7230139B2 (en) 2002-12-05 2007-06-12 Gemin X Biotechnologies Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
BRPI0409681A (pt) * 2003-04-23 2006-04-18 Wyeth Corp derivados de wortmanina solúveis em água
DE102004043463A1 (de) * 2004-06-09 2006-02-09 Heinz Voigt Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten
US7446124B2 (en) 2004-07-09 2008-11-04 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
TW200626610A (en) * 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
WO2006132675A2 (en) * 2004-12-20 2006-12-14 University Of South Florida Xiap-targeted prostate cancer therapy
EP1940386A4 (en) * 2005-09-01 2010-06-23 Beth Israel Hospital WORDMAN'S CONJUGATES AND USES THEREOF
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
WO2007120364A2 (en) * 2005-12-30 2007-10-25 Arizona Board Of Regents, Acting On Behalf Of The University Of Arizona Metabolites of wortmannin analogs and methods of using the same
WO2007120897A2 (en) * 2006-04-13 2007-10-25 The Trustees Of Columbia University In The City Of New York Compositions and intraluminal devices for inhibiting vascular stenosis
EP2575459A4 (en) * 2010-06-04 2014-03-12 Oncothyreon Inc CANCER TREATMENT WITH WORDMAN ANALOGA
JP2013527247A (ja) * 2010-06-04 2013-06-27 オンコシレオン インク． ウォルトマンニンアナログによる併用の癌治療
US11197854B1 (en) 2018-11-14 2021-12-14 National Technology & Engineering Solutions Of Sandia, Llc Inhibitors for targeting flaviviruses
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Also Published As

Publication number Publication date
WO2003024183A3 (en) 2003-06-12
EP1435941A2 (en) 2004-07-14
CA2458318A1 (en) 2003-03-27
MXPA04002445A (es) 2005-07-25
JP2005507880A (ja) 2005-03-24
ATE334671T1 (de) 2006-08-15
JP4540986B2 (ja) 2010-09-08
DE60213633D1 (de) 2006-09-14
WO2003024183A2 (en) 2003-03-27
EP1435941A4 (en) 2004-12-08
EP1435941B8 (en) 2006-10-25
EP1435941B1 (en) 2006-08-02
AU2002330029B2 (en) 2006-07-06
DE60213633T2 (de) 2007-11-08

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20190916