JP4532261B2 - 生物学的試料のための光線画像分析 - Google Patents
生物学的試料のための光線画像分析 Download PDFInfo
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- JP4532261B2 JP4532261B2 JP2004502240A JP2004502240A JP4532261B2 JP 4532261 B2 JP4532261 B2 JP 4532261B2 JP 2004502240 A JP2004502240 A JP 2004502240A JP 2004502240 A JP2004502240 A JP 2004502240A JP 4532261 B2 JP4532261 B2 JP 4532261B2
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/40—Extraction of image or video features
- G06V10/42—Global feature extraction by analysis of the whole pattern, e.g. using frequency domain transformations or autocorrelation
- G06V10/421—Global feature extraction by analysis of the whole pattern, e.g. using frequency domain transformations or autocorrelation by analysing segments intersecting the pattern
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/695—Preprocessing, e.g. image segmentation
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
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- Computer Vision & Pattern Recognition (AREA)
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- Radiology & Medical Imaging (AREA)
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- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Image Analysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Image Processing (AREA)
Description
図6の光線40に沿って位置するピクセルに対応するピクセル強度レベルデータのグラフを図8に示す。図7の光線40に沿って位置するピクセルに対応するピクセル強度レベルデータのグラフを図9に示す。これらの各グラフでは、青色チャネルの画像データを点線で示し、緑色のチャネルの画像データを実線で示す。ピクセル強度レベル(例えば、12ビットのデジタル化方式を用いて測定される)を核44内のシード点48からの半径方向距離の関数としてプロットする。各光線に対する強度レベル情報は、画像取得機器14により取り込まれる2次元画像から抽出することができる。
42 細胞
44 核
48 シード点
50 交差点
Claims (15)
- 細胞系アッセイにおいて細胞(42)を含む試料(12)に対する試験化合物の作用を評価する方法であって、上記細胞(42)が核(44)を含んでいて、当該方法が、
試料(12)を試験化合物に暴露する段階と、
試料(12)からデジタル画像データ(32)を取得する段階と、
上記画像データ(32)を分析して核(44)の少なくとも1つを識別する段階と、
上記核(44)の少なくとも1つについて、シード点位置(48)を決定する段階と、
上記シード点位置(48)に基づいて、複数の半径方向光線(40)を発生させる段階と、
上記複数の半径方向光線(40)に沿った距離の関数として画像強度データを集める段階と、
上記画像強度データを分析して、上記複数の半径方向光線(40)に対する平均及び統計情報を含む結果を生成する段階と、
上記結果を、試験化合物に暴露する前の試料(12)で得られた結果と比較する段階と
を含む方法。 - 前記画像データを走査型レーザ顕微鏡で取得する段階を更に含む、請求項1に記載の方法。
- 前記複数の半径方向光線(40)を前記核(44)内の共通の位置に起点を有するように定める段階を更に含む、請求項1又は請求項2に記載の方法。
- 前記核(44)が境界(46)を有し、当該方法が更に、前記複数の半径方向光線(40)の起点が前記核(44)の境界(46)にあるように前記複数の半径方向光線(40)を定める段階を更に含む、請求項1乃至請求項3のいずれか1項に記載の方法。
- ユーザに光線終端基準を指定する機会を提供する段階を更に含む、請求項1乃至請求項4のいずれか1項に記載の方法。
- 前記複数の半径方向光線(40)の各々に沿った距離が、ユーザ指定の長さにより決定される、請求項1乃至請求項5のいずれか1項に記載の方法。
- 前記複数の半径方向光線(40)が、別の細胞(42)の核(44)と交差する各光線が交差点で終端するように更に定められる、請求項1乃至請求項6のいずれか1項に記載の方法。
- 前記複数の半径方向光線(40)が、該光線の各々が、前記核(44)から外向きに延び、前記複数の半径方向光線(40)の少なくとも1つに関連する画像データ(32)の強度レベルが所定の強度レベル閾値より低くなると終端するように更に定められる、請求項1乃至請求項7のいずれか1項に記載の方法。
- 前記画像データ(32)が、各々異なる波長(λ)の光と関連した複数のチャネルのデータを含んでいて、前記画像データ(32)を分析して核(44)の少なくとも1つを識別する段階が上記チャネルの少なくとも1つについて分析して核(44)を識別することを含む、請求項1乃至請求項8のいずれか1項に記載の方法。
- 前記画像データ(32)の各々が関連ピクセル強度レベルを有する複数の半径方向ピクセルを含む、請求項1乃至請求項9のいずれか1項に記載の方法。
- 前記複数の半径方向光線(40)が互いに等間隔の角度に配置される、請求項1乃至請求項10のいずれか1項に記載の方法。
- 前記核(44)が境界(46)を有し、前記複数の半径方向光線(40)が前記核(44)内の起点から始まると共に外向き方向に放射して前記複数の半径方向光線(40)が前記核(44)の境界(46)に位置する少なくとも1つのピクセルを通過するように定められる、請求項1乃至請求項11のいずれか1項に記載の方法。
- 前記画像データ(32)が複数のピクセルを含み、前記核(44)が境界(46)を有し、前記複数の半径方向光線(40)の各々が、前記核(44)の境界(46)のピクセルから始まって核(44)の全ての光線(40)が前記核(44)内の共通点に投射されるような方向に前記核(44)から離れて延びる、請求項1乃至請求項12のいずれか1項に記載の方法。
- 前記画像データ(32)が、各々異なる波長(λ)の光と関連した複数のチャネルに対するデータを含む、請求項1乃至請求項13のいずれか1項に記載の方法。
- 前記画像強度データを分析する段階が、前記核(44)に関して前記光線(40)のどれが有効であるかを求める段階を含み、有効な光線の各々が、起点と終端点との間にユーザ指定の数より多いピクセルを含む、請求項1乃至請求項14のいずれか1項に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/136,096 US6658143B2 (en) | 2002-04-29 | 2002-04-29 | Ray-based image analysis for biological specimens |
PCT/US2003/013500 WO2003094101A1 (en) | 2002-04-29 | 2003-04-29 | Ray-based image analysis for biological specimens |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005524090A JP2005524090A (ja) | 2005-08-11 |
JP4532261B2 true JP4532261B2 (ja) | 2010-08-25 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004502240A Expired - Fee Related JP4532261B2 (ja) | 2002-04-29 | 2003-04-29 | 生物学的試料のための光線画像分析 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6658143B2 (ja) |
EP (2) | EP1500035B1 (ja) |
JP (1) | JP4532261B2 (ja) |
AT (1) | ATE418116T1 (ja) |
AU (1) | AU2003225247A1 (ja) |
CA (1) | CA2481094A1 (ja) |
DE (1) | DE60325345D1 (ja) |
ES (1) | ES2319175T3 (ja) |
WO (1) | WO2003094101A1 (ja) |
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-
2003
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- 2003-04-29 CA CA002481094A patent/CA2481094A1/en not_active Abandoned
- 2003-04-29 EP EP03721966A patent/EP1500035B1/en not_active Expired - Lifetime
- 2003-04-29 AT AT03721966T patent/ATE418116T1/de not_active IP Right Cessation
- 2003-04-29 AU AU2003225247A patent/AU2003225247A1/en not_active Abandoned
- 2003-04-29 EP EP08171482A patent/EP2040198A1/en not_active Withdrawn
- 2003-04-29 ES ES03721966T patent/ES2319175T3/es not_active Expired - Lifetime
- 2003-04-29 JP JP2004502240A patent/JP4532261B2/ja not_active Expired - Fee Related
- 2003-04-29 WO PCT/US2003/013500 patent/WO2003094101A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2003094101A1 (en) | 2003-11-13 |
JP2005524090A (ja) | 2005-08-11 |
AU2003225247A1 (en) | 2003-11-17 |
CA2481094A1 (en) | 2003-11-13 |
EP1500035B1 (en) | 2008-12-17 |
EP1500035A1 (en) | 2005-01-26 |
EP2040198A1 (en) | 2009-03-25 |
EP1500035A4 (en) | 2007-07-18 |
ATE418116T1 (de) | 2009-01-15 |
US6658143B2 (en) | 2003-12-02 |
DE60325345D1 (de) | 2009-01-29 |
ES2319175T3 (es) | 2009-05-05 |
US20030202689A1 (en) | 2003-10-30 |
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