JP4530665B2 - 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 - Google Patents
放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 Download PDFInfo
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- JP4530665B2 JP4530665B2 JP2003565315A JP2003565315A JP4530665B2 JP 4530665 B2 JP4530665 B2 JP 4530665B2 JP 2003565315 A JP2003565315 A JP 2003565315A JP 2003565315 A JP2003565315 A JP 2003565315A JP 4530665 B2 JP4530665 B2 JP 4530665B2
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- tolylphosphonium
- fluorobenzyl
- imaging agent
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- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
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- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
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- A—HUMAN NECESSITIES
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- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| TWI266634B (en) * | 2002-02-06 | 2006-11-21 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| CN1839142B (zh) | 2003-08-22 | 2010-06-16 | 澳新制药公司 | 用作靶向线粒体的抗氧化剂的线粒体醌衍生物 |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| EP2388017B1 (en) * | 2004-02-24 | 2014-12-24 | The General Hospital Corporation | Catalytic radiofluorination |
| AU2011203177B2 (en) * | 2004-02-24 | 2012-04-26 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) * | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| US7738096B2 (en) | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
| JP2006315958A (ja) * | 2005-05-10 | 2006-11-24 | Nihon Medi Physics Co Ltd | 放射性ハロゲン標識有機化合物の製造方法 |
| US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| US8163039B2 (en) | 2006-08-03 | 2012-04-24 | Hammersmith Imanet Limited | Fluoride drying method |
| US20100111867A1 (en) * | 2007-02-16 | 2010-05-06 | The University Of Sydney | Carborane-phosphonium compounds and their use in boron neutron capture therapy and imaging |
| EP1990310A1 (en) * | 2007-04-23 | 2008-11-12 | Trasis S.A. | Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step |
| EP2164524B1 (en) * | 2007-05-30 | 2013-08-07 | Children's Medical Center Corporation | Fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography |
| US9717896B2 (en) | 2007-12-18 | 2017-08-01 | Gearbox, Llc | Treatment indications informed by a priori implant information |
| US8636670B2 (en) | 2008-05-13 | 2014-01-28 | The Invention Science Fund I, Llc | Circulatory monitoring systems and methods |
| US20090287120A1 (en) | 2007-12-18 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
| US8388936B2 (en) * | 2008-02-22 | 2013-03-05 | Mcw Research Foundation, Inc. | In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging |
| ES2767973T3 (es) * | 2008-02-29 | 2020-06-19 | Lantheus Medical Imaging Inc | Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión |
| US8388931B2 (en) * | 2008-02-29 | 2013-03-05 | Marcos Lopez | 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors |
| CA2718035C (en) | 2008-03-21 | 2017-10-24 | The General Hospital Corporation | Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders |
| CN102036652B (zh) | 2008-04-25 | 2016-04-13 | 西北大学 | 适于螯合胆甾醇的纳米结构 |
| JP5322527B2 (ja) * | 2008-07-17 | 2013-10-23 | 浜松ホトニクス株式会社 | アポトーシスの検出に適した化合物 |
| DK2419096T3 (da) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre |
| EP2451760A1 (en) | 2009-07-10 | 2012-05-16 | Bayer Pharma Aktiengesellschaft | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers |
| AU2011213568B2 (en) | 2010-02-08 | 2016-05-12 | Lantheus Medical Imaging, Inc. | Methods and apparatus for synthesizing imaging agents, and intermediates thereof |
| GB201005624D0 (en) * | 2010-04-01 | 2010-05-19 | Medical Res Council | Probe |
| US9205156B2 (en) | 2010-05-27 | 2015-12-08 | Hadasit Medical Research Services & Development Limited | Molecular imaging agents |
| KR101172157B1 (ko) | 2010-05-27 | 2012-08-07 | 전남대학교산학협력단 | 미토콘드리아 영상을 위한 방사성 약물의 제조 방법 |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN102898470B (zh) * | 2012-11-02 | 2014-12-10 | 北京师范大学 | 一类新型有机膦化合物及其制备方法和应用 |
| CN105939699B (zh) | 2013-12-03 | 2020-10-02 | 西北大学 | 脂质体颗粒、制备所述脂质体颗粒的方法以及其用途 |
| WO2016057549A1 (en) | 2014-10-06 | 2016-04-14 | Aurasense Therapeutics, Llc | Anti-tnf compounds |
| JP6555719B2 (ja) * | 2014-11-05 | 2019-08-07 | 国立大学法人東北大学 | ホスホニウム化合物およびその製造方法 |
| TWI611795B (zh) * | 2016-07-18 | 2018-01-21 | 許百靈 | 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途 |
| CN107233585B (zh) * | 2017-06-09 | 2021-01-22 | 四川大学华西医院 | 黄连素或其衍生物在制备心肌灌注显像剂中的用途 |
| KR20200028997A (ko) | 2017-07-13 | 2020-03-17 | 노오쓰웨스턴 유니버시티 | 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법 |
| PL239871B1 (pl) * | 2018-09-05 | 2022-01-24 | Synektik Spolka Akcyjna | Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej |
| CN110577478A (zh) * | 2018-10-25 | 2019-12-17 | 南方医科大学南方医院 | 一种正电子探针及其制备方法与应用 |
| US20220347323A1 (en) * | 2019-09-18 | 2022-11-03 | The Regents Of The University Of California | Positron Emission Tomography Guided Delivery of Mitochondral Complex I Inhibitors |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
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| US4446123A (en) * | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
| CA2302360C (en) | 1997-09-03 | 2005-11-15 | Immunomedics, Inc. | Fluorination of proteins and peptides for f-18 positron emission tomography |
| JPH11295494A (ja) | 1998-04-08 | 1999-10-29 | Nippon Meji Physics Kk | ［ｆ−１８］−フッ化物イオンの製造方法 |
| US6630125B2 (en) * | 2000-04-28 | 2003-10-07 | Duke University | 18F-labeled choline analogs |
| EP1174771B1 (en) * | 2000-06-21 | 2008-06-11 | Canon Kabushiki Kaisha | Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus |
| TWI266634B (en) * | 2002-02-06 | 2006-11-21 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| WO2004032621A2 (en) | 2002-08-01 | 2004-04-22 | The Johns Hopkins University | Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence |
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| JP2005532262A (ja) | 2005-10-27 |
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